Academic Profile

Academic Profile

Assoc Prof Liang Zhao-Xun

Associate Professor, School of Biological Sciences

Email: zxliang@ntu.edu.sg
Phone: +65 65927736
Office: SBS 03S 53
Assoc Prof Liang Zhao-Xun

Biography
Associate Prof Liang Zhao-Xun is currently in the School of Biological Sciences since Sep 2005. He received his Bachelor degree in Chemistry from Lanzhou University (China) and Ph.D. degree in Chemistry from the Northestern Unversity (US). His research focuses on the structure and function of proteins, particularly the enzymes involved in the biosynthesis of secondary metabolites and bacterial biofilm formation.
Research Interests
I am interested in the structure and function of some newly discovered proteins that are of potential importance for the treatment of human diseases. The proteins under investigation range from enzymes involved in antitumor natural products biosynthesis to potential antimicrobial targets in pathogenic bacteria.
Current Projects
  • A Novel Approach to Controlling Biofilm Thickness for Efficient Biocatalysis
  • A study of the biosynthetic mechanism of orchratoxin A for the control of toxin production in food commodities
  • Antimicrobial natural products from rare actinomycetes
  • Biosynthetic Mechanism of Antitumor Enediyne Natural Products
  • Design and Synthesis of Functional C-di-GMP Deriatives as Biological Probes and Antibacterial Agents
  • Discovery and engineering of nitrile oxidoreductase as biocatalysts for nitrile reduction
  • Function of c-di-GMP effectors in the human pathogen Pseudomonas aeruginosa
  • Heterologous production of cannabinoids in proprietary Streptomyces hosts
  • In situ cultivation of "unculturable" actinomycetes in micro-gel droplets
  • Structure and Function of the Polyketide Synthase in Enediyne Biosynthesis
  • Structure and function of novel antibiotic target fimX in apportunistic pathogen pseudomonas aeruginosa
  • Structure and regulation of c-di-GMP signalling proteins in pathogenic bacteria
  • Study of the Biosynthetic Mechanism of Salinosporamide A for Developing Novel Proteasome Inhibitors
Selected Publications
  • . K.-H. Chin, Z.-L. Tu, Y.-C. Su, Y.-J. Yu, H.-C. Chen, Y.-C. Lo, C.-P. Chen, G. Barber, M.L.-C. Chuah, Z.-X. Liang and *S.-H. Chou. (2013). Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING. Acta Crystallographica, D69, 352-366.
  • Ho, C. L., Chong, K. S. J., Oppong, J. A., Chuah, M. L. C., Tan, S. M., *Liang, Z.-X. (2013). Visualizing the perturbation of cellular cyclic di-GMP levels in bacterial cells.. Journal of the American Chemical Society, 135, 566-569.
  • Tan, E., Rao, F., Pasunooti, S., Soehano, I., Liew, C. W., Lescar, J., *Pervushin, K., *Liang, Z.-X. (2013). Solution structure of a small PAS domain in cyclic di-AMP signaling reveals a ligand-binding site. Journal of Biological Chemistry, 26, 11949-11959.
  • Sun H, Ho CL, Ding F, Soehano I, Liu X-W, and Liang Z-X. (2012). Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase. Journal of the American Chemical Society, 134(29), 11924–11927.
  • Lim, J., Sun, H., Fan, J.-S., Hameed, I. F., Lescar, J., Liang, Z.-X., *Yang, D. (2012). Rigidifying the acyl carrier protein domain of the iterative polyketide CalE8 does not affect its function. Biophysical Journal, 103, 1037-1044.

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