Academic Profile

Academic Profile

Asst Prof Ma Wei

Assistant Professor, School of Biological Sciences

Email: weima@ntu.edu.sg
Phone: +65 69047230
Office: SBS 02S 88E
Asst Prof Ma Wei

Biography
Education

• Ph.D. in Plant Science, University of Connecticut 2008

• M.S. in Biochemistry and Molecular Biology, Chinese Academy of Agricultural Sciences 2004

• B.S. in Biotechnology, Agricultural University of Hebei 2001

Professional Experience

• Senior Research Associate,Great Lakes Bioenergy Research Center, Michigan State University, USA

• Research Associate,Great Lakes Bioenergy Research Center, Michigan State University, USA

• Research Associate,DOE-Plant Research Laboratory, Michigan State University, USA
Research Interests
Research of my lab focuses on mechanistic understanding of gene regulation of plant oil biosynthesis and translation of knowledge gained from our research into benefits for agro-economy. Plant cells accumulate oil in the form of triacylglycerol (TAG) in their seeds as a main resource of carbon and energy for seedling development. Plant oils are not only essential for the human diet but also provide renewable feedstock for many industrial uses. Transcription factor, WRINKLED1 (WRI1) is a key regulator of plant oil biosynthesis. We show that post-translational modifications (PTMs), interacting partners, and regulatory domains (or motifs) of WRI1 are critical for its functions. For example, a C-terminal IDR3 domain (containing a PEST motif) affects the stability of AtWRI1. Removal of the IDR3-PEST motif or mutation of putative phosphorylation-sites in the IDR3-PEST motif increases the stability of AtWRI1, resulting in increased oil production. In addition, we have demonstrated that AtWRI1 interacts with 14-3-3s, a family of phosphopeptide-binding proteins. Co-expression of 14-3-3s with AtWRI1 increases AtWRI1-mediated oil biosynthesis as a consequence of boosted transcriptional activity of AtWRI1. We seek to establish an interactome of WRI1 through identification of the WRI1 interacting protein partners. We are interested in globally mapping binding targets for WRI1 via whole-genome chromatin immunoprecipitation sequencing (ChIP-Seq) and DNA affinity purification sequencing (DAP-seq). My lab will also investigate combinatorial transcriptional regulation of fatty acid biosynthesis in oil crops, with a goal of identifying novel regulators that can be used to improve oil crops.
Current Projects
  • Elucidation of the molecular mechanism of a regulator of plant oil biosynthesis in mediating plant hormone homeostasis and cell proliferation
  • Functional characterization of WRINKLED1 (WRI1) in seed oil biosynthesis & development and Development of high oil crops
  • Molecular basis of genetic colonizal Agrobacteria exiting the infectious mode by release of defense signal salicylic acid

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