Academic Profile

Academic Profile

Assoc Prof Surajit Bhattacharyya

Associate Professor, School of Biological Sciences

Email: surajit@ntu.edu.sg
Phone: +65 63167997
Office: SBS 02S 78
Assoc Prof Surajit Bhattacharyya

Biography
Prof Surajit Bhattacharyya is currently in the School of Biological Sciences since 2005. He received his Bachelor degree in Agricultural Sciences from India, Master in Biotechnology from India and Ph.D. degrees from the Indian Institute of Science, Bangalore, India respectively. Before joining NTU, SBS, Prof Bhattacharyya was Staff Scientist at the National Research Council of Canada, Montreal. His research interests include Structural Biology using NMR spectroscopy, and drug design. He has done significant research work his research areas and published over 70 top quality international conference and journal papers. He has been often invited as a referee and reviewer for a number of premier journals, including Nature Communications, Scientific Reports, Biochemistry, Langumur, Biopolymers, BBA, JACS and other ACS journals. Prof Bhattacharyya serves as an Academic Editor of the journals PLOS-ONE and Scientific Reports. Prof Bhattacharyya is a Fellow of the Royal Society of Chemistry (FRSC) and Overseas Fellow of the Royal Society of Medicine (UK). Prof Bhattacharyya has developed courses for undergraduate students and actively engaged in teaching these courses.
Research Interests
Molecular Mechanism of cell adhesion: Interactions of Integrin Tails with Effector Proteins
Designed Peptide Antagonists against Endotoxin: A structure-based approach to develop antisepsis and antimicrobial drugs.
De Novo designed functional mini-proteins
Structure and activity of antimicrobial peptides
Current Projects
  • Analyses of signaling protein interactions with the alpha cytosolic domains of beta2 integrins
  • Development Of Anticancer Therapeutics From A Lead Proapoptotic Peptide Targeting Cell-Surface GRP78
  • Multi-protein Complexes Interacting with b2 integrin: Structure-Function
  • Multifunctional Antimicrobial Peptide Conjugated Nanosensor towards Real-Time Identification and Simultaneous Capture of Toxic Bacterial Lipopolysaccharide
  • Multifunctional Antimicrobial peptide conjugated nanosensor towards real-time identificaiton and simultaneous capture of toxic bacterial lipopolysaccharide
  • Solution structures of peptides and protein fragments in complex with lipopolysaccharide by nuclear magnetic resonance (NMR) spectroscopy : Towards a rational development of anti-sepsis drugs
  • Stability, folding and interactions of the sterile alpha-motifs (SAM Domains) from signaling cascades of yeast
  • Structural investigations of YidC mediated membrane protein insertion
  • Structure and Dynamics of Membrane active Viral Proteins by NMR Spectroscopy
  • Structures and Interactions of Potent Antimicrobial Peptides with Lipopolysaccharide
  • The molecular and structural bsis of leukocyte b2 integrins signalling
Selected Publications
  • Joyce Seow Fong Chin, Sheetal Sinha, Anjaiah Nalaparaju, Joey Kuok Hoong Yam, Zhiqiang Qin, Luyan Ma, Zhao-Xun Liang, Lanyuan Lu, Surajit Bhattacharjya and Liang Yang. (2017). Pseudomonas aeruginosa Psl Exopolysaccharide Interacts with the Antimicrobial Peptide LG21. Water, .
  • Mukesh Mahajan and Surajit Bhattacharjya. (2014). Designed di-heme binding helical transmembrane protein. ChemBioChem, .
  • Fang Liu, Jing Mu, Xiangyang Wu, Surajit Bhattacharjya,* Edwin Kok Lee Yeow and Bengang Xing. (2014). Peptide-perylene diimide functionalized magnetic nano-platforms for fluorescence turn-on detection and clearance of bacterial lipopolysaccharides. Chemical Communications, .
  • Harini Mohanram and Surajit Bhattacharjya. (2014). Resurrecting inactive antimicrobial peptides from lipopolysaccharide (LPS) trap. Antimicrobial Agents and Chemotherapy, 58, 1987-1996.
  • Harini Mohanram and Surajit Bhattacharjya. (2014). Beta-boomerang antimicrobial and antiendotoxic peptides: lipidation and disulfide bond in activity and structure. Pharmaceuticals , 7, 482-501.

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