Academic Profile

Academic Profile

Prof Phan Anh Tuan

Associate Chair (Faculty), School of Physical & Mathematical Sciences
Interim Director, NTU Institute of Structural Biology
Professor, School of Physical & Mathematical Sciences
Professor (Courtesy)

Email: phantuan@ntu.edu.sg
Prof Phan Anh Tuan

Biography
Professor Phan received his Bachelor’s and Master’s degrees in Physics and Mathematics from Lomonosov Moscow State University (Russia) in 1995, Master’s degree in Biophysics from University of Paris-Sud (France) in 1996, and PhD in Biophysics from École Polytechnique (France) in 1999. He took up postdoctoral and research positions in École Polytechnique (1999 - 2000) and Memorial Sloan-Kettering Cancer Center, New York (USA) (2001 - 2006). He joined the Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, NTU as an Assistant Professor in 2006 and was promoted to Associate Professor in 2011 and to Full Professor in 2016. He was the Head of the Division of Physics and Applied Physics from November 2011 to December 2018. He was elected as a Fellow of the American Physical Society (APS) in 2014, in recognition of “his significant contributions in understanding non-canonical nucleic acid motifs, particularly the i-motif and the G-quadruplex, by developing novel NMR techniques”. In 2017 he was awarded the Singapore NRF Investigatorship for a research program focusing on the development structure-enhanced nucleic acid therapeutics.
Research Interests
Professor Phan's research is at the interface between Physics, Chemistry and Biology. His group uses a combination of physical, chemical, biological and computational methods to investigate and manipulate properties of biomolecules. The research goals include:

(1) Structures, dynamics, interactions and functions of DNA, RNA and proteins.
(2) Noncanonical structures of DNA and RNA as molecular targets against diseases.
(3) Structural design and engineering of nucleic acids and proteins.
(4) Application and development of methods, including Nuclear Magnetic Resonance (NMR) and other spectroscopic techniques, as well as single-molecule manipulations, for the study of biomolecular structures and dynamics.
Current Projects
  • Biophysical Study of DNA and DNA-Ligand Complexes
  • G-Quadruplex-Induced Genome Instability
  • Guanine-rich DNA Oligomers: Structure and Activity Against HIV and Cancer
  • Left-Handed G-Quadruplexes: Biophysical Properties and Biological Function
  • NTU Center Of High Field Nuclear Magnetic ResonanceSpectroscopy And Imaging (NMRs)
  • Potential DNA Quadruplexes In Human Minisatellites
  • Recognition of G-quadruplex Nucleic Acids by Proteins: From Structure to Design
  • Solid State Nanopore Devices for Single Molecule Biophysics and Sequencing
  • Structural Analysis of HMGA-DNA Complexes at Abasic Sites
  • Structural and Dynamic Basis for DNA and RNA G-Quadruplex Recognition by Ligands
  • Structurally and Chemically Controlled G-Quadruplex DNA: Understanding and Application in Therapeutics
Selected Publications
  • Heddi B, Cheong VV, Martadinata H, Phan AT. (2015). Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(31), 9608-9613.
  • Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT. (2015). Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(9), 2729-2733.
  • Chung WJ, Heddi B, Tera M, Iida K, Nagasawa K, Phan AT. (2013). Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative. Journal of the American Chemical Society, 135(36), 13495-13501.
  • Lim KW, Phan AT. (2013). Structural basis of DNA quadruplex-duplex junction formation. Angewandte Chemie International Edition, 52(33), 8566-8569.
  • Mukundan VT, Phan AT. (2013). Bulges in G-quadruplexes: Broadening the definition of G-quadruplex-forming sequences. Journal of the American Chemical Society, 135(13), 5017-5028.

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