Academic Profile

Academic Profile

Prof Leung Pak Hing

Professor, School of Physical & Mathematical Sciences

Email: pakhing@ntu.edu.sg
Prof Leung Pak Hing

Biography
Prof. Leung received his B.Sc.(Hons) from the Polytechnic of North London, he went on to do his PhD from the Australian National University, and did post-doctoral work at the University of Toronto and the University of Chicago.Professor Leung has been a JSPS visiting fellow at University od Tsukuba,Imperial College and University of Newcastle upon Tyne. Before he joint NTU in March 2005, he was a full Professor and the Deputy Head of the Chemistry Department at NUS. He has received the Outstanding Researcher Award and numerous Outstanding Teaching Awards from NUS. He is currently the Head of the Division of Chemistry and Biological Chemistry at the School of Physical and Mathematical Sciences (SPMS) as well as Associate-Chair at SPMS. His research interests are focussed mainly on development of asymmetric synthetic methodologies with an aim of applying the compounds in catalysis and as ant-tumor agents.Prof. Leung is an internationally known researcher in asymmetric synthesis and organometallic chemistry of chiral phosphine complexes.He currently holds an International patent for an Anti-cancer drug which is undergoing Stage II trials.
Research Interests
The research interest is in the area of asymmetric synthesis and optical resolution of novel P-chiral phosphine ligands. An efficient approach to generate the desired stereoisomeric form of a particular ligand by means of an unusual exo-endo stereochemically controlled asymmetric Diels-Alder reaction, using a chiral organopalladium complex as the reaction promoter have been developed. With this catalyst, it is now possible to produce one particular target molecule in a controllable and specific manner. Currently, these findings are applied to the synthesis of new anti-cancer gold drugs. Thus far, preliminary biological tests indicate that these new drugs exhibit high activity towards various human cancerous diseases with minimal side effects. The catalytic properties of these newly generated chiral phosphines are also being investigated.
Current Projects
  • Arsenic Clusters and P-Chiral Phosphines via Metallacycle Catalyzed Protocols and their Applications in Catalysis, Sensing and Drug Design
  • Development of Functionalized Phosphine Gold-Based Complexes for Breast Cancer Therapy
  • Development of New Generation of Chiral Tertiary Phosphine Ligands for Application in Catalysis and Chemotheraphy
  • Development of New Methodologies in the Synthesis of Chiral Silicon-Phosphorous Compounds
  • Development of Novel Metal Phosphine Chomplexes As Potential Chemotherapeutic Agents
  • Development of Novel Phosphorus Compounds and their Applications
  • Development of Organometallic Compounds as Catalysts for C-N Bond Activation
  • Novel Metal Chelator as Corrosion Inhibitor in Photoresist Stripper
  • Synthesis of Biologically Active Chiral Gold Phospine Complexes
Selected Publications
  • Krishnan, Deepa; Pullarkat, Sumod A.; Wu, Meiyi; Li, Yongxin; Leung, Pak-Hing. (2013). Synthesis, Structural Characterisation and Stereochemical Investigation of Chiral Sulfur-Functionalised N-Heterocyclic Carbene Complexes of Palladium and Platinum. Chemistry - A European Journal, 19(17), 5468-5475.
  • Krishnan, Deepa; Wu, Meiyi; Chiang, Minyi; Li, Yongxin; Leung, Pak-Hing; Pullarkat, Sumod A. (2013). N-Heterocyclic Carbene C,S Palladium(II) π-Allyl Complexes: Synthesis, Characterization, and Catalytic Application In Allylic Amination Reactions. Organometallics, 32(8), 2389-2397.
  • Pullarkat, Sumod A.; Leung, Pak-Hing. (2013). Chiral metal complex-promoted asymmetric hydrophosphinations. Organometallics, 43, 145-166.
  • Chew, Renta Jonathan; Huang, Yinhua; Li, Yongxin; Pullarkat, Sumod A.; Leung, Pak-Hing. (2013). Enantioselective Addition of Diphenylphosphine to 3-Methyl-4-nitro-5-alkenylisoxazoles. Advanced Synthesis and Catalysis, 355(7), 1403-1408.
  • Tan. KW, Yang. XY,Li. YX,Huang. YH,Pullarkat. SA and Leung. PH. (2012). Reactivity of Cycloplatinated Amine Complexes: Intramolecular C-C Bond Formation, C-H Activation, and PPh2 Migration in Coordinated Alkynylphosphines. Organometallics, 31(23), 8407-8413.

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