Academic Profile

Academic Profile

Prof Chan Bee Eng, Mary

Professor, School of Chemical and Biomedical Engineering

Email: mbechan@ntu.edu.sg
Prof Chan Bee Eng, Mary

Biography
Dr Mary Chan-Park is the 2019 Board of Trustees Chaired Professor of Chemical and Biomedical Engineering at the Nanyang Technological University Singapore (NTU Singapore). She also holds a joint appointment at the Lee Kong Chian School of Medicine at NTU. She is the Director of the Centre for Antimicrobial Bioengineering, and also the Director of the Nanyang Food Technology Centre (NAFTEC). She is a Fellow of the America Institute of Medical and Biological Engineering. She is also an associate editor of the American Chemical Society (ACS) Applied Materials & Interfaces

She obtained her BEng (Chemical) and PhD (Polymers) from the National University of Singapore and MIT in 1986 and 1993. respectively.
Research Interests
Her main research interests are in polymers in nanoscience and biotechnology. She has published extensively, with more than 240 papers in top-tier journals. She is a leader in the field of antibacterial and antibiofilm polymers. Her group has invented a new class of potent cationic antimicrobial polymers which are non-toxic and biocompatible. Her antibacterial polymers are more environmentally friendly than current disinfectives and are being applied as device coatings and solutions to fight the global Antimicrobial Resistance (AMR) public health crisis. These new antimicrobial polymers have been reported in Angewandte Chemie (2020), Chemical Science (2020), Nature Communications (2019), Nano Letters (2018), ACS Nano (2015), Advanced Materials (2012) and Nature Materials (2011). Her polymers are explored for human and animal infections.

The key inventions of Mary include glycosylated block co-beta-peptides that can eradicate biofilm and persister bacteria that are not easily treatable by classical antibiotics and which are the cause of recurrent infections. She also invented a series of polyimidazoliums that have antibiotic-like properties and ultra-high selectivity window, so that these can be exploited in complex consumer care products. She pioneered microporous antibacterial hydrogels that kill bacteria through acting as an anion sponge. These hydrogel coatings have been applied to contact lens and wound dressing

Her patents have been used by/licensed to companies. Professor Mary Chan contributes actively to the industry through industry cooperation projects, consultancy and licensing of her technologies.
Current Projects
  • 2019 Board of Trustees Chair in Chemical and Biomedical Engineering
  • Antibacterial and Biofunctional Wound Dressing
  • Antimicrobial polymeric nanoparticles with good efficacy in a complex environment
  • Development of sustainable, biodegradable packaging materials for enhancing safety and quality of food
  • Evaluation of the prebiotic potential of Tamu's fiber mixtures in batch gut model including crystallization study
  • Fabrication of Disposable Biochips using UV embossing Technology
  • NTU Food Technology Center (NAFTEC)
  • Novel silver nanoparticle/Multi-walled carbon nanotube nanohybrid coating for disinfection and biofouling control in drinking water treatment
  • Project C - Hierarchical Composite Research
  • Selective Contact-active Cationic Antimicrobial Biomacromolecules
  • Selective contact-active antimicrobial bio-macromolecules
  • Suspension of carbon nanotubes by polymers for sensing
  • Sustainable Antimicrobial Polymer Technology for Application in Consumer Products
  • Synthetic Biology Collaboration with Imperial College
  • Targeting bacterial membrane biology with novel main chain cationic polymers
  • Targeting bacterial membrane biology with novel main chain cationic polymers (overhead portion to Lead PI)
Selected Publications
  • Thappeta KRV, Vikhe YS, Yong AMH, Chan-Park MB, Kline KA. (2020). Combined Efficacy of an Antimicrobial Cationic Peptide Polymer with Conventional Antibiotics to Combat Multidrug-Resistant Pathogens.. ACS Infectious Diseases, .
  • Zhangyong Si, Hui Wen Lim, et al, Guillermo C. Bazan, E. Peter Greenberg, Mary B. Chan-Park, Kevin Pethe. (2020). A Glycosylated Cationic Poly(b-peptide) Reverses IntrinsicAntibiotic Resistance in All ESKAPE Gram-NegativeBacteri. Angewandte Chemie International Edition, 59, 6819-6826.
  • Kaixi Zhang, Yu Du, et al Kevin Pethe, Mary B. Chan-Park. (2019). Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters. Nature Communications, .
  • D Pranantyo, LQ Xu, ET Kang, MB Chan-Park. (2018). Chitosan-based Peptidopolysaccharides as Cationic Antimicrobial Agents and Antibacterial Coatings. Biomacromolecules, .
  • Jianghua Li, et al, Liang Yang, Mary B. Chan-Park. (2018). Block Copolymer Nanoparticles Remove Biofilms of Drug-Resistant Gram-Positive Bacteria by Nanoscale Bacterial Debridement. Nano Letters, .

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