Academic Profile

Academic Profile

Assoc Prof Lu Lei

Associate Professor, School of Biological Sciences

Email: lulei@ntu.edu.sg
Assoc Prof Lu Lei

Biography
1997 bachelor University of Science and Technology of China, Hefei, China
2004 PhD Institute of Molecular and Cell Biology, Singapore
2004—2006 post-doc Institute of Molecular and Cell Biology, Singapore.
2006—2010 post-doc Harvard Medical School / Immune Disease Institute, Boston, USA
2010—present Asst. Prof. School of Biological Sciences, Nanyang Technological University
Research Interests
1) Membrane trafficking at the Golgi complex.
2) Signaling and the membrane trafficking.
3) Ciliary targeting mechanism.
Current Projects
  • A novel Mon2 signaling network in organelle positioning and nutrient sensing
  • A systematical and functional study of ARF like small GTPases
  • CY2001 Research Attachment 1 module
  • Carboxyl Graphene-Based Imaging and Detection of Human Histone Acetyltransferase’s Activity in Living Cells and in Cell-Free Systems
  • Cellular imaging, detection, and inhibition of cancer-affiliated human AP endonuclease (APE1)
  • Detection, Imaging and Inhibitory Studies of Poly(A)-Specific Ribonuclease in Acute Myeloid Leukemia Cells
  • Detection, Imaging and Inhibitory Studies of Poly(A)-Specific Ribonuclease in Acute Myeloid Leukemia Cells
  • Development of Cutting-Edge DNA Nanogels for Pharmaceutical and Medical Applications
  • Membrane trafficking in mTOR signaling and autophagy — the roles of Golgi localized ARF-like GTPases
  • Nanostructure- and Fluorophore-Based Platforms for Inhibitor-Screening and Detection of Human DNA Ligase I
  • Numerical Golgi protein localization by imaging centroids of induced mini-stacks (GLICIMS) and its application in studying extracellular stimuli regulated Golgi re-organization
  • The Biogenesis of Nuclear Envelope and Nuclear Pores
  • The discovery and characterization of a novel small GTPase that directly regulates the canonical TGFbeta signaling pathway
  • The mechanistic study of the effect of amino acids on the endocytic trafficking
  • The role of importins in targeting ciliary membrane proteins
Selected Publications
  • Tie, HC, Ludwig, A, Sandin, S, Lu, L. (2018). The spatial separation of processing and transport functions to the interior and periphery of the Golgi stack. eLIFE, 30(7), doi: 10.7554/eLife.41301.
  • Shi M, Chen B, Mahajan D, Boh BK, Zhou Y, Dutta B, Tie HC, Sze SK and Lu L. (2018). Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5. Nature Communications, 9, 4987.
  • Zhang H, Ba S, Mahajan Da, Lee JY, Ye R, Shao F, Lu L and Li T. (2018). Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems.. ACS Nano, 18(11), 7383–7388.
  • Karthikeyan A, Gupta N, Tang C., Mallilankaraman K, Silambarasan M, Shia M, Lu L, Ang BT, Ling, EA and Dheen ST. (2018). Microglial SMAD4 regulated by microRNA-146a promotes migration of microglia which support tumor progression in a glioma environment. Oncotarget, 9(38), 24950-24969.
  • Yan Wang, Heng Zhang, Meng Shi, Yih-Cherng Liou, Lei Lu, Fengwei Yu. (2017). Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Development, .

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