|Academic Profile |
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Prof Laurent Claude Renia
|Laurent Renia obtained his PhD in 1991 Universite Pierre et Marie Curie in Paris, France where he studied the immune response against the preerythrocytic phase of malaria. He continued to work on malaria immunology in New York University (1991-1992). He then returned to Paris in 1993 where he obtained a permanent position as junior research scientist at the French national of Institute of Health (INSERM) working on malaria immunology in the INSERM Unit 313 at the Hospital Pitie-Salpetriere in Paris. He moved to the INSERM Unit 445 at the Institut Cochin in Paris where he started his own group in 1997. Between 2001-2006, he became research director at INSERM, co-director and director of the Department of Immunology at the Institut Cochin. He joined the Singapore Immunology Network in 2007. He isa lso adjunct Professor at the School of Biological at NTU and at the department of Microbiology at NUS.|
|Malaria is one of the most serious infectious disease of humans, with 300–600 million clinical cases and 1-2 million deaths annually. Adaptive immune responses in the host limit the clinical impact of infection and provide partial protection against pathogen replication; Worldwide, most infections are clinically silent, reflecting the ability of adaptive immune mechanisms to prevent disease. In non-immune individuals, infections are more clinically overt, and a minority of these can become severe or life threatening, manifesting a range of overlapping syndromes of complex aetiologies. |
Our global objectives are:
1) to identify correlates of protection or pathology against Plasmodium infection. This will allow to determine whether the immune responses associated with specific antigens play a role in the induced protection and subsequently to identify mechanisms of this protection against infection.
2) to define the basis of parasite sequestration and how the immune system can participate or interfere with this process.
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