Academic Profile

Academic Profile

Assoc Prof Pu Kanyi

Associate Professor, School of Chemical and Biomedical Engineering

Email: kypu@ntu.edu.sg
Assoc Prof Pu Kanyi

Biography
Dr. Pu joined the School of Chemical and Biomedical Engineering (SCBE) at NTU as an Associate Professor in June 2015. Till now, he has published more than 144 journal papers, 3 book chapters and 6 patents. With a h-index of 60 (July 2019), his work has been highlighted by many world-renown scientific journals such as Nature Biotechnology, Nature Nephrology Review, Nature Methods, and Cell Express et al.. He has won a number of awards for his creative work, including Distinguished Lectureship Award from the Chemical Society of Japan, Wiley Award for Contribution in Bioscience, Young Investigator Travel award from WMIC, and Young Innovator Award in Nanobiotechnology by Nano Research.

Dr. Pu received his B.E. (2004) and M.S. (2007) respectively from ECUST and Fudan University in China. He then came to Singapore and did his PhD (2011) at National University of Singapore. He moved to Stanford University School of Medicine for his postdoctoral study in 2011 in the molecular imaging program at Stanford (MIPS).

Dr. Pu has made significant contributions to the development of molecular imaging probes and technologies, particularly for photoacoustic imaging, chemiluminescence imaging and afterglow imaging. He is well known for his work on semiconducting polymer nanomaterials (SPNs) for molecular imaging, phototherapy and photoregulation. He is the inventor of the polymeric nanoreporters for molecular afterglow imaging and the molecular optical renal reporters for early diagnosis of acute kidney injury (AKI).

Dr. Pu serves as the associate editor for ACS Applied Polymer Materials and Biomaterials Research, and as the Young Star Editor for Nano Research. He also sits on the Editorial Advisory Board of many high-impact multidisciplinary journals including Advanced Functional Materials, Bioconjugate Chemistry, ACS Applied Bio Materials, Advanced Biosystems, and ChemNanoMat.
Research Interests
The board research objective in my group is to develop multifunctional platform technologies for understanding, detection and treatment of life-threatening diseases. Toward this goal, we will take an interdisciplinary approach that brings together organic chemistry, nanotechnology and molecular biology to synthesize functional polymers, polish their optoelectronic and biochemical properties, and shape them into smart and biocompatible nanoagents for advanced molecular imaging and amplified therapy.

(1) Molecular Imaging: Detection and monitoring of pathological processes in disease microenvironment at the molecular level for prognosis, diagnosis and therapeutic outcome assessment
(2) Chemical Biology: Design and synthesis of activatable imaging probes to uncover how reactive radical species modulate tumor metabolism, promote metastasis and angiogenesis, and foster drug resistance phenotypes
(3) Materials Science: Development of organic semiconducting nanomaterials with state-of-art imaging modalities such as photoacoustic imaging, near-infrared fluorescence imaging and bioluminescent imaging to improve imaging penetration depth and spatial resolution
(4) Biotechnology: Development of noninvasive high-throughput technologies for drug screening with a focus on real-time in vivo imaging of drug metabolism and evolution of drug-induced toxicity
Current Projects
  • Development of Biothiol-responsive Optical Nanoprobes for In Vivo Evaluation of Drug Toxicity
  • Molecular Afterglow Imaging for Ultrasensitive Detection of Lymphatic Metastasis
  • Organic Semiconducting Nanoplatform for Moelcular Imaging and Amplified Therapy
  • Organic photonic nanoprobes for in vivo imaging of neurodegenerative diseases
  • Ultrasensitive Nanobioimaging Technologies for Advanced Healthcare
Selected Publications
  • Yuyan Jiang, Jiaguo Huang, Xu Zhen, Ziling Zeng, Jingchao Li, Chen Xie, Qingqing Miao, Jie Chen, Peng Chen, Kanyi Pu*. (2019). A generic approach towards afterglow luminescent nanoparticles for ultrasensitive in vivo imaging.. Nature Communications, 10, 2064.
  • Jiaguo Huang, Jingchao Li, Yan Lyu, Qingqing Miao, Kanyi Pu. (2019). Molecular Optical Imaging Probes for Early Diagnosis of Drug-Induced Acute Kidney Injury. Nature Materials, , DOI: 10.1038/s41563-019-0378-4.
  • Jingchao Li, Jiaguo Huang, Yan Lyu, Jingsheng Huang, Yuyan Jiang, Chen Xie, and Kanyi Pu. (2019). Photoactivatable Organic Semiconducting Pro-nanoenzymes. Journal of the American Chemical Society, 141(9), 4073-4079.
  • Xu Zhen, Chen Xie, Kanyi Pu*. (2018). Temperature-correlated afterglow of a semiconducting polymer nanococktail for imaging-guided photothermal therapy. Angewandte Chemie International Edition, 57, 3938-3942.
  • Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V Jokerst & Kanyi Pu*. (2017). Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nature Biotechnology, 35(11), 1102-1110.

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