Academic Profile

Academic Profile

Asst Prof Hou Han Wei

Assistant Professor, School of Mechanical & Aerospace Engineering

Email: hwhou@ntu.edu.sg
Phone: +65 67904950
Office: N3 02C 86
Asst Prof Hou Han Wei

Biography
Dr. Hou Han Wei joined the School of Mechanical and Aerospace Engineering in January 2018 as an Assistant Professor. He received his BEng (First Class Hons) and PhD degree in Biomedical Engineering at the National University of Singapore (NUS) in 2008 and 2012, respectively. Upon graduation, he did his postdoctoral training at Massachusetts Institute of Technology (MIT). In 2014, Dr. Hou joined the Lee Kong Chian School of Medicine (LKCMedicine) at NTU as the inaugural LKCMedicine Postdoctoral Fellow.

Dr. Hou has over 30 peer-reviewed scientific publications and 6 patents/patent applications on microfluidic cell separation technologies. His work has been featured in online science (ScienceDaily, TheScientist, Cancerforall and Genomeweb), healthcare (News Medical), as well as technology magazines (Gizmag, Nanowerk). He has received several scientific awards including the Singapore-MIT Alliance for Research and Technology (SMART) Graduate Fellowship (2009), Young Investigator Award at the 6th World Congress of Biomechanics (2010), and LKCMedicine Postdoctoral Fellowship (2014). His PhD work on the development of a high-throughput spiral microfluidics biochip for circulating tumor cells (CTCs) isolation has been licensed to Clearbridge BioMedics Pte Ltd, a Singapore-based biotech company, and is currently their flagship product for cancer diagnostics.

Research group website: http://www.hwhoulab.com
Research Interests
-Microtechnologies and biosensors for blood diagnostics
-Label-free immune cell phenotyping for rapid risk stratification in metabolic disorders
-Circulating microvesicles and exosomes as novel biomarkers for non-invasive vascular health profiling
-Biomimetic microengineered human organ-on-chip platforms for precision medicine
Current Projects
  • An integrated microfluidic urine impedance cytometer for rapid inflammation, pathogen and resistance detection
  • Blood Vessel-on-a-Chip: A Biomimetic Model to Study theImmunodulatory Effects of Vitamin D in Atherosclerosis
  • Development of an integrated point-of-care microfluidic platform for leukocyte sorting and functional characterization in type 2 diabetes patients
  • Effects of Dapagliflozin and Metformin on Vascular Function in Newly-Diagnosed Treatment-Naive Type 2 Diabetes - A Randomized Controlled Trial (DMVascular Study)
  • Functional-based cell sorting (FunCS): Label-free microfluidic isolation, phenotyping and sorting of dysfunctional leukocytes in type 2 diabetes mellitus
  • High throughput microfluidic enrichment of circulating blood cells for disease diagnostics
  • Integrated microfluidics for rapid vascular health profiling in diabetes using liquid biopsy
  • Microfluidic approaches for point-of-care immune and vascular health profiling in type 2 diabetes mellitus
Selected Publications
  • N.V. Menon, H.M. Tay, K.T. Pang, R. Dalan, S.C. Wong, X.M. Wang, K.H.H. Li and H.W. Hou*. (2018). A tunable microfluidic 3D stenosis model to study leukocyte-endothelial interactions in atherosclerosis. APL Bioengineering, 2(1), 016103.
  • H.M. Tay, R. Dalan, K.H.H. Li, B.O. Boehm* and H.W. Hou*. (2017). An integrated microdevice for neutrophil functional phenotyping in diabetes testing. Small, , 17022832.
  • N.V. Menon, H.M. Tay, S.N. Wee, K.H.H. Li and H.W. Hou*. (2017). Micro-engineered perfusable 3D vasculature for cardiovascular diseases. Lab on a Chip, 17(17), 2960-2968.
  • Tay HM, Kharel S, Dalan R, Chen ZJ, Tan KK, Boehm BO, Loo SCJ, Hou HW*. (2017). Rapid purification of sub-micrometer particles for enhanced drug release and microvesicles isolation. NPG Asia Materials, 9, 434.
  • Hou HW, Petchakup C, Tay HM, Tam ZY, Dalan R, Chew DEK, Li KHH, Boehm BO. (2016). Rapid and label-free microfluidic neutrophil purification and phenotyping in diabetes mellitus. Scientific Reports, 6.

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