|Dr. Dinish obtained his Ph.D. in bio-optics and imaging in 2005 from Nanyang Technological University (NTU), Singapore. Currently, he is working as Research Scientist at Singapore Bioimaging Consortium, A*STAR and concentrating on the development of optical and multi modal imaging techniques for translational research.|
His research interests are in translational biophotonics and specifically aim to develop photonics technologies for various applications in biomedicine. Various photonics techniques being researched for biosensing applications include Raman and surface enhanced Raman scattering (SERS). SERS platforms are developed for biomarker sensing for both preclinical and clinical applications using novel substrate and metallic nanoparticle configurations. SERS active nanoparticles (SERS nanotags) are also developed for multiplex detection of biomarkers both ex vivo and in vivo in an animal model. Cutting edge specialty fiber based SERS active optical probes are also being developed by combining novel nanomaterial strategies for direct biomarker sensing in clinical biofluids. Multifunctional fiber optic probe by strategically combining various optical sensing methodologies is also developed to extract complementary information in preclinical and clinical biosensing applications. On the other hand, photoacoustic imaging (PAI, both tomography and microscopy) is studied for various translational bioimaging applications. Multimodal optical contrast agents (in the form of chemical probes) for PAI and SERS are also used for various in vivo bioimaging applications.
He holds 9 patents/patent applications and has published over 80 international journal papers and conference proceedings/articles with a current H index of 17. Recently, he co-edited a book titled 'Frontiers in Biophotonics for Translational Medicine' published by Springer in 2015. He also authored 4 book chapters and won young investigator and best paper awards in international conferences in 2006 and 2012. Dinish organized and chaired special sessions on bio-optical imaging and sensing in international photonics conferences. He is serving as reviewer for 14 leading international journals in the field of optics, bio-optics, nanotechnology and won certificate of appreciation for review service (2012, 2013, 2014 and 2015) from the editor of Journal of Biomedical Optics (JBO), SPIE, USA. Currently, he is serving as the editorial board member of ‘Scientific Reports’ (Nature Publishing Group) in biological physics category. Dinish is also holding an honorary role as consulting editor in the ‘International Journal of Nanomedicine’ (Dove press) since 2015.
- Malini Olivo, Dinish U. S (Editors). (2015). Frontiers in Biophotonics for Translational Medicine. Springer.
- U. S Dinish, Zhegang Song, Chris Jun Hui Ho, Ghayathri Balasundaram, Amalina Binte Ebrahim Attia, Xianmao Lu, Ben Zhong Tang, Bin Liu, Malini Olivo. (2015). Single Molecule with Dual Function on Nano-gold: Biofunctionalized Construct for in vivo Photoacoustic Imaging and SERS Biosensing. Advanced Functional Materials, 25(15), 2316.
- Stefano Vavassori, Anil Kumar, Gan Siok Wan, Gundimeda S. R, Marco Cavallari, Sary El Daker, Travis Beddoe, Alex Theodossis, N. K. Williams, Emma Gostick, D. A. Price, Dinish U. S., Kong Kien Voon, Malini Olivo, Jamie Rossjohn, Lucia Mori, Gennaro De Libero. (2013). Butyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nature Immunology, 14, 908-916.
- K. W. Kho, U. S. Dinish, Anil Kumar, Malini Olivo. (2012). Frequency shift in SERS for biosensing. ACS Nano, 6, 4892-49.
- K. K. Maiti1, U. S. Dinish1, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Sung Jin Park, Malini Olivo, Y. T Chang. (2012). Multiplex Targeted in vivo cancer detection using sensitive near-infrared SERS nanotags. Nano Today, 7, 85-93 (1: Joint first authors).