Academic Profile

Academic Profile

Asst Prof Dalton Tay Chor Yong

Assistant Professor, School of Materials Science & Engineering
Assistant Professor, School of Biological Sciences

Asst Prof Dalton Tay Chor Yong

Dr. Dalton Tay received his B. Eng (1st Class Honors) and Ph.D. from the School of Materials Science and Engineering, Nanyang Technological University (NTU) in 2007 and 2012 respectively. His Ph.D. research focused on the development of novel micropatterend bio-polymeric surfaces to direct lineage specification of adult stem cells for regenerative medicine. In 2012, he joined the National University of Singapore (NUS) as a Lee Kuan Yew (LKY) postdoctoral fellow with the Department of Chemical and Biomolecular Engineering. During his post-doctoral tenure, he majored in the etiology of inorganic nanomaterials triggered biological responses within the framework of biosafety and nanotherapeutics. In addition, he has also developed several bio-inspired nano-micro systems that could be applied for diagnostic and screening applications. He subsequently joined the School of Materials Science and Engineering (NTU) as an Assistant Professor in September 2015.
Research Interests
The overarching focus of Dr Tay’s research lies at the nexus between small scale (micro-nano) biomaterials and biology. His research group seeks to understand and develop novel biomaterials-centric strategies to control livings systems for biomedicine and biotechnology.

Areas of current research include:

(i) Micro-nano scale technologies for regenerative medicine and biosensing
(ii) Mechano-chemical signal transduction in eukaryotes
(iii) “Self-therapeutic” nanomaterials
(iv) 3D printed bio-inspired micro-physiological systems for cancer and skin research
Current Projects
  • 3D-bioprinting of hydrogel-based biomimetic systems for screening applications
  • Anti-fibrotic cellular encapsulation for diabetic therapy
  • Bioactive Stem Cells Secretome-Enriched Hydrogels for Chronic Wound Healing
  • Biomimetic Short Peptide Hydrogels for Chronic Wound Healing
  • Elucidating the adaptive response of human respiratory cells to printer-emitted nanoparticles
  • Employment of bio-mimetic culture system as tumor microenvironment surrogate to elucidate tumor-stroma interaction
Selected Publications
  • C. Y. Tay, Y-L. Wu., P. Cai, N. S. Tan, S.S Venkatraman, X. Chen, L. P Tan. (2015). Bio-inspired micropatterned hydrogel to direct and deconstruct hierarchical processing of geometry-force signals by human mesenchymal stem cells during smooth muscle cell differentiation. NPG Asia Materials, 7, e199.
  • C. Y. Tay, L. Yuan, D. T Leong. (2015). Nature-Inspired DNA nanosensor for real-time in situ detection of mRNA in Living Cells. ACS Nano, 9(5), 5609-5617.
  • M. I. Setyawati, C. Y. Tay, D. Docter, R. H. Stauber, D. T. Leong. (2015). Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood. Chemical Society Reviews, , (in press).
  • C.Y. Tay, M.I. Setyawati, J. Xie, W.J. Parak, D.T. Leong. (2014). Back to Basic: Exploiting the innate physico-chemical characteristics of nanomaterials for biomedical applications. Advanced Functional Materials, 24(38), 5936-5955.
  • C.Y. Tay, P. Cai, M.I. Setyawati, W. Fang, L.P. Tan, C.H.L. Hong, X. Chen, D.T. Leong. (2014). Nanoparticles strengthen intracellular tension and retard cellular migration. Nano Letters, 14(1), 83-88.

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