Academic Profile

Academic Profile

Asst Prof Tan Chin Hong

Assistant Professor, School of Social Sciences

Asst Prof Tan Chin Hong

Dr. Tan received his PhD in Psychology (Cognitive Neuroscience) from the University of Illinois and his BSocSci(Hons) from NUS. Before joining NTU in late 2018, he was a Postdoctoral Scholar in the Neuroradiology Section of the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. Dr. Tan's research interest lies broadly in using multimodal neuroimaging data (MRI, PET, DOT) and genetics to understand the earliest risk markers of neurodegenerative diseases. More specifically, he studies the influence of polygenic risk and cerebrovascular health on cognitive decline and progression to clinical dementia. Dr. Tan's research in the cognitive neuroscience and genetics of aging and dementia has been published in high impact journals such as Acta Neuropathologica, Annals of Neurology, and Brain.
Research Interests
Cognitive neuroscience of ageing, Cerebrovascular disease, Alzheimer's polygenic risk, Human neuroimaging, Diffuse optical tomography, Cardiorespiratory fitness, Cognitive decline and progression to clinical dementia.

I have experience working on various research projects with clinicians from different specialties including neurologists, neuroradiologists, and geriatricians. If you are a clinician looking for a scientific collaborator, please feel free to contact me.
Current Projects
  • Associations of amyloid deposition with a magnetic resonance imaging (MRI) measure of cerebrovascular and degenerative pathology in individuals with mild cognitive impairment
  • Socioeconomic Status and Cognitive Impairment: The Mediating Effects of Cardiovascular Function and Brain Volume
Selected Publications
  • Tan CH, Low KA, Chiarelli AM, Fletcher MA, Navarra R, Burzynska AZ, Kong TS, Zimmerman B, Maclin EL, Sutton BP, Gratton G, Fabiani M. (2019). Optical Measures of Cerebral Arterial Stiffness are Associated with White Matter Signal Abnormalities and Cognitive Performance in Normal Aging. Neurobiology of Aging, .
  • Tan CH*, Bonham LW*, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GS, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS. (2019). Polygenic Hazard Score, Amyloid Deposition and Alzheimer’s Neurodegeneration. Brain, 142(2), 460-470 [*joint-first].
  • Tan CH, Desikan RS. (2018). Interpreting Alzheimer's disease polygenic scores. Annals of Neurology, 83(3), 443-445.
  • Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, Feldman HA, Holland D, McEvoy LK, Hyman BT, Andreassen OA, Dale AM, Desikan RS. (2018). Polygenic hazard score: an enrichment marker for Alzheimer’s associated amyloid and tau deposition. Acta Neuropathologica, 135(1), 85-93.
  • Tan CH, Hyman BT, Tan JJX, Hess CP, Dillon WP, Schellenberg GD, Besser LM, Kukull WA, Kauppi K, McEvoy LK, Andreassen OA, Dale AM, Fan CC, Desikan RS. (2017). Polygenic hazard scores in preclinical Alzheimer disease. Annals of Neurology, 82(3), 484-488.

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