Academic Profile

Academic Profile

Prof Subramanian Venkatraman

Executive Director, NTU Institute for Health Technologies
Professor, School of Materials Science & Engineering

Prof Subramanian Venkatraman

Dr.Subbu Venkatraman has a PhD in Polymer Chemistry from Carnegie-Mellon University. He has spent about 15 years in biomedical R&D in the USA, working with various applications of polymeric biomaterials. He held a senior position in R&D at Alza Corporation prior to joining NTU as Associate Professor in 2000. Since then he has published extensively in the field of biomaterials, with a total of 130 publications, and a citation count of 1300+ and a h-index of 23. He also holds 20 issued US patents in biomaterials/drug delivery, and 5 of these have been translated into products. He is concurrently the Director of the Ocular Therapeutic Engineering Centre, as well as Dy Director of the Nanyang Institute of Technology in Health & Medicine, and works closely with clinicians from Singapore and world-wide.
Research Interests
Research is focussed on the applications of polymeric biomaterials in medicine. In particular, research areas include biodegradable stents, injectable drug delivery systems and gene delivery. Controlled release of drugs to the eye and the cardiovascular system are the primary end applications. Cancer therapy using "stealth" particles also forms a significant component of the research activities.
Current Projects
  • A New Glaucoma Drainage Device with Sustained Drug Elution
  • A Swellable Drug Loaded Coating for Stents to Target Fibrosis-Induced Ureteral Stricture
  • A localized sustained delivery system for the management of common male patterned baldness
  • A new biodegradable, sustained-release drug delivery system in a rabbit model
  • A*Star-NTU-NHG Skin Research Initiative - NTU Funding
  • Advanced and Innovative Stapler Device for Haemorrhoidectomy
  • Adventitial drug delivery using nanoparticles for treatment of Critical Limb Ischemia
  • Amaranth Medical 1
  • Amaranth Medical 2
  • Anti-fibrotic cellular encapsulation for diabetic therapy
  • AntiReflux – Non-refluxing stent (NRS) Project
  • AntiReflux- Non-refluxing stent (NRS) Project
  • Autonomous, Low Cost, Ultrasensitive Water Monitoring SystemFor Cyanotoxins Based On Ferromagnetic Particles
  • Biodegradable Cardiovascular Implants
  • Biodegradable Cardiovascular Implants: Biodegradable Elastomers
  • Biodegradable Cardiovascular Implants: Cell-Biomaterials Interactions II
  • Biodegradable Cardiovascular Implants: Surface Functionalization for Cell Growth
  • Biodegradable Shape Memory Foam Plug for Temporary Endovascular Embolization in Interventional Radiology
  • Biodegradeable stents for hemodialysis vascular access intervention
  • Biodegradeable stents for hemodialysis vascular access interventions
  • Biologics DDS
  • Bone-targeting Nanomedicine for Treating Osteomyelitis
  • Cardiovascular Cellular Delivery Systems: Natural and Synthetic
  • Co-Funding For Joint Project Under The Ntu-Linkoping University Memorandum Of Understanding: Biomaterials Enhanced Cell-Based Therapy
  • Controlled Drug Delivery From Core-Shell Nanofibers in Polymeric Matrices (NTU-Technion)
  • DDS
  • Developing "Smart" Topical Delivery System
  • Development and application of sustained drug release technology for the delivery of nucleic acid molecules for the prevention of post-operative scarring in glaucoma
  • Development of a Fully Bioresorbable Grommet (BRG) Tube
  • Development of a nanocarrier drug delivery system for a novel anti-vascular endothelial growth factor (anti-VEGF) in the treatment of age-related macular degeneration
  • Development of novel bioabsorbable drug-eluting ventilation tube for chronic middle ear infection
  • Drug Delivery Systems For Glaucoma And Cornea Research Collaboration With Singapore Eye Research Institute (SERI)
  • Drug delivery systems for glaucoma and cornea
  • Drug-Eluting Balloons (DEB) Controlled Delivery through Nanoparticulate Coating
  • Dual Eye Drop Formulation To Suppress T Cell-Mediated Inflammation And Replenish Lipids In Dry Eye Disease
  • Early detection of central venous catheter-related bloodstream infection
  • Fully biodegradable drug eluting stents for hemodialysis vascular access interventions
  • Fundamental studies of Nanocarriers for Drug and Protein Delivery
  • General Research Project
  • In vitro studies of nanoliposomes encapsulated aspirin for treatment of diabetic retinopathy
  • Innovation and Entrepreneurship
  • Key technologies for developing microorganisms-derived hyaluronic acid for biomedical applications
  • Monetary Academic Resources for Research
  • Myopia-1: Sustained release formulation for atropine delivery
  • NANO-SORB: Thin Biodegradable PLLA Stent Material Using Nanocomposite Fillers
  • NANOLIMUS: Sustained Sirolimus Delivery via Adventitial Infusion of Nanoparticles for Treatment of Peripheral Artery Disease
  • Nanoparticle Therapeutics for Age-Related Macular Degeneration and Diabetic Edema
  • Nanostructured Hydrogels: Characterization & Applications
  • Nanostructured hydrogels for Cardiac Tissue Engineering
  • Nanotechnology to Diagnose, Prevent, and Treat Cardiovascular Disease
  • Nanotechnology to Diagnose, Prevent, and Treat Cardiovascular Disease
  • Novel Drug Delivery Platform based on Coated Ureteral Stents for reducing Ureteral Fibrosis and Strictures
  • Novel drug delivery platform based on coated ureteral stents for reducing ureteral fibrosis and strictures
  • Novel sustained release drug delivery system for retinal diseases with application of nanotechnology for ocular pharmacotherapy
  • Nuclear Safety Science Summer School
  • Optimizing local immunimodulation therapy for reducing the health and economic burden of surgical site infections
  • Oral Insulin Delivery
  • Oral Insulin Delivery (Gap Funding)
  • Self-Expanding Biodegradable Heart Plug
  • Structural characterization of drugs/siRNA loaded nanoparticles by high resolution transmission electron microscopy
  • Sustained Delivery of An Anti-Hair Loss Drug
  • Synthesis and Characterization of Biodegradable Thermoplastic Elastomers
  • Tailored drug delivery platform for reducing ureteral fibrosis and strictures: Bilayer ureteral coated stents
  • The Regenerative Medicine Initiative in Cardiac Restoration Therapy Research Programme
  • The Skin Research Institute of Singapore, Phase 2: SRIS@Novena
  • The development of fully biodegradable occluder
  • Understanding the influence of the physicochemical properties of biodegradable nanoparticles on oral trans-epithelial transport
  • Vesico-Urethral Connector
Selected Publications
  • Ye Cao, Subbu S Venkatraman. (2019). The long-term delivery of protein and peptide using micro/nanoparticles: overview and perspectives. Therapeutic Delivery, .
  • XW Ng, JH Wan, SS Venkatraman. (2019, February). Nanosome and liposome delivery for atopic dermatitis. Paper presented at 10th International Congress on Skin Ageing & Challenges, Porto, Portugal.
  • Hui Yee Chua, Yuan Siang Lui, Ramya Bhuthalingam, Rupesh Agrawal, Tina Wong, Peter Rainer Preiser, Subbu Venkatraman. (2018). One-step solid-oil-water emulsion for sustained bioactive ranibizumab release. Expert Opinion in Drug Delivery, 15(12), 1143-1156.
  • U. Sarig, H. Sarig, A. Gora, G. C. T. Au-Yeung, E. de Berardinis, S. Y. Chaw, E. Zussman, S. Ramakrishna, F. Y. C. Boey, S. S. Venkatraman, M. Machluf. (2018). Biological and mechanical interplay at the Macro-and Microscales Modulates the Cell-Niche Fate. Scientific Reports, 8(1), 3937.
  • Tijore A, Behr JM, Irvine SA, Baisane V, Venkatraman S. (2018). Bioprinted gelatin hydrogel platform promotes smooth muscle cell contractile phenotype maintenance.. Biomedical Microdevices, 20(2), 32.

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