|Dr. Amartya Sanyal joined NTU as Nanyang Assistant Professor in School of Biological Sciences (SBS) in 2014. The laboratory of Dr. Sanyal is interested in understanding the chromatin basis of transcriptional regulation during cellular state transitions. The laboratory employs high-throughput genomics, genome-editing and imaging techniques in combination with bioinformatics and computational approaches to understand structure-function relationship of chromatin in various model organisms. The ultimate goal is to decipher systems-level understanding of complex relationships between genome architecture, gene transcription and, chromatin and epigenetic features in normal development and disease. Prior to this position, Dr. Sanyal worked at the University of Massachusetts Medical School, Worcester, MA, USA for his postdoctoral training. During his postdoctoral tenure, he was actively involved in the ENCODE (ENCyclopedia Of DNA Elements) project. Dr. Sanyal’s work has been published in leading research journals and is highly cited. Recently, his group has reported the first gapless chromosome-level genome assembly and chromatin contact map of the pathogenic yeast, Candida tropicalis. |
Keywords: 3D chromatin organization; Epigenetics; Gene expression; Cancer; Liver biology; Bioinformatics; Computational Biology
Ph.D. (2008) Indian Institute of Science, Bangalore, India
M.Sc. (2002) Banaras Hindu University, Varanasi, India
B.Sc. (2000) University of Calcutta, Kolkata, India
- Guin K, Chen Y, Mishra R, Muzaki SRBM, Thimmappa BC, O’Brien C, Butler G, Sanyal A*, Sanyal K*. (2020). Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres. eLIFE, 9, e58556.
- Khalil AIS, Khyriem C, Chattopadhyay A*, Sanyal A*. (2020). Hierarchical discovery of large-scale and focal copy number alterations in low-coverage cancer genomes. BMC Bioinformatics, 21(1), 147.
- Sreekumar L, Jaitly P, Chen Y, Thimmappa BC, Sanyal A, Sanyal K. (2019). Cis- and trans-chromosomal interactions define pericentric boundaries in the absence of conventional heterochromatin.. Genetics, 212(4), 1121-1132.
- Hong R, Lin B, Lu X, Lai LT, Chen X, Sanyal A, Ng HH, Zhang K, Zhang LF. (2017). High-resolution RNA allelotyping along the inactive X chromosome: evidence of RNA polymerase III in regulating chromatin configuration. Scientific Reports, 7, 45460.
- McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST; CAMP Research Group. (2016). Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. American Journal of Respiratory and Critical Care Medicine, 194(12), 1465-1474.