Academic Profile

Academic Profile

Asst Prof Chen Albert I-Ming

Assistant Professor, School of Biological Sciences

Asst Prof Chen Albert I-Ming

Albert Chen is an Assistant Professor in the School of Biological Sciences. He received his undergraduate degree at the University of Illinois at Urbana-Champaign and Ph.D. from Columbia University where he examined the specification of motor neuron subtype identity and sensory neuron axonal targeting in the spinal cord. As a postdoctoral fellow at the University of California, San Francisco, he transitioned to studying supraspinal motor structures, exploring the molecular mechanisms underlying the assembly and maintenance of neural circuits in the cerebellum, a brain region critical for sensorimotor integration and voluntary motor control.
Research Interests
Research in the Chen Lab employs a multidisciplinary approach to pursue two major aims: 1) to define the molecular, anatomical, and functional distinctions of neuronal subpopulations in the nervous system that control specific behaviors; and 2) to identify and characterize genes that direct the assembly and maintenance of neural circuits. These general issues are examined through the analysis of local and long-range circuits in subcortical brain centers important for coordination and refinement of movement, motor learning, and cognitive behaviors using genetic and viral circuit tracing, neural manipulations, and behavioral approaches in mice.
Current Projects
  • Control of discrete and rhythmic movement by cerebello-thalamo-cortical circuits
  • Defining the brain circuitry defects that cause dementia
  • Neurotrophic factors and the assembly of inhibitory circuits in the cerebellum
  • The Role of Cadherin-13(CDH13) in the Development and Function of the Brain Circuitry and Its Implication for Autism Spectrum Disorders (ASDs)
  • Warwick-NTU Neuroscience Research @ Singapore (WN2R@S) On Opto-Genetic Tools For Investigating Glial Cell Biology(Principal Investigators: Asst Prof Albert I. Chen and AsstProf Ayumu Tashiro)
Selected Publications
  • Thanawalla, A.R., Chen, A.I.*, Azim, E.*. (2020). The cerebellar nuclei and dexterous limb movements. Neuroscience, S0306-4522(20)3, *co-corresponding authors.
  • Kamath, S.P. and Chen, A.I. (2018). Myocyte enhancer factor 2c regulates dendritic complexity and connectivity of cerebellar Purkinje cells. Molecular Neurobiology, s12035, 1-18.
  • Tan, S., Xiao, Y., Yin, H.H., Chen, A.I., Soong, T.W., Je, H.S. (2018). Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), pnas.1812083115.
  • Low, A.Y.T.*, Thanawalla, A.R.*, Yip, A.K.K.*, Kim, J., Wong, K.L.L., Tantra, M., Augustine, G.J. and Chen, A.I. (2018). Precision of discrete and rhythmic forelimb movements requires a distinct neuronal subpopulation in the interposed anterior nucleus. Cell Reports, 22(9), 2322-2333. *these authors contributed equally.
  • Tantra, M.*, Guo, L.*, Kim, J., Zainolabidin, N., Eulenburg, V., Augustine, G.J., Chen, A.I. (2018). Conditional deletion of Cadherin-13 perturbs Golgi cells and disrupts social and cognitive behaviors. Genes, Brain and Behavior, e12466, *these authors contributed equally.

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