Academic Profile

Academic Profile

Prof Xing Bengang

Professor, School of Physical & Mathematical Sciences - Division of Chemistry & Biological Chemistry
Professor, School of Chemical and Biomedical Engineering

Prof Xing Bengang

Dr. Xing received his Bachelor Degree in Chemistry from Xinjiang Normal University 1994, and Ph.D. Degree from Nanjing University in 2000, respectively. After that, he moved to the Department of Chemistry, at the Hong Kong University of Science and Technology (HKUST) as a research staff. In 2003, Dr. Xing went to the Crump Institute of Molecular Imaging at the University of California, Los Angeles (UCLA) and the Molecular Imaging Program at Stanford University (MIPS) to pursue his post-doc research training. In Dec. of 2005, he started his independent research career at the Division of Chemistry & Biological Chemistry (CBC), School of Physical & Mathematical Sciences (SPMS), Nanyang Technological University (NTU), where he was promoted to a tenured Associate Professor in 2011. From 2011 to 2018, Dr. Xing was holding the appointments as Deputy Head in CBC and Assistant Chair in SPMS for academic education. In 2019, Dr. Xing was officially installed as Full Professor in NTU.

Awards and Honor Representatives:

2007 The Asian Core Program (ACP), Lectureship Award, South Korea
2011 Lectureship Award for Chemistry Research Promotion Center National Science Council. Taiwan.
2013 Collaborative Research Award, College of Sciences, NTU
2015 COS idea competition Award, College of Science, NTU
2016 The Reaxys phD prize, as supervisor
2018 Young Innovator Award in Nano-biotechnology, featured by Nano Research
Research Interests
Dr. XING's research interests are highly interdisciplinary at the interfaces of Biomedical Fluorescent Imaging, Chemical Biology as well as Nano-medicine and Pharmaceutical Chemistry. Specific aims of ours are to integrate the knowledge of synthesis chemistry, chemical biology and optical imaging sensing techniques to develop the "smart" probes and contrast agents for real-time sensing of diseases active molecules or precisely monitoring of biomedical pathway in living systems. We are also interested in development of unique functional nanomaterials for drug/gene delivery, biocatalysis and multi-modality imaging of biomarkers, unique biomolecules and reactive radical species (e.g. ROS, RNS etc) for potential clinical diagnosis.

1. Biomedical Fluorescent Imaging / Chemical Biology:

a) Development of new fluorescent probes and specific labeling strategies for point-of-care imaging of drug resistant bacterial pathogens.
b) Unique strategies for real-time monitoring of bioactive molecules in tumor cells.
c) Site-specific localization of unique probe contrast agents for precise regulation of cell functions.

2. Nano-theranostics:

a) Unique and smart NIR light mediated functional platforms for localized tumor theranostics.
b) Multi-modality sensing and imaging of biomarkers, unique biofunctional molecules as well as reactive radical species under living settings.
c) NIR light mediated optogentics for precise regulation of disease cell functions.

3. Biomaterials:

Design, synthesis and characterization of new transporters and/or the peptides based hydrogels for biomedical applications.
Current Projects
  • Allenamide: Platform Technology for Antibody-Drug Conjugates (ADC) 2.0
  • Antimicrobial Materials Against Drug-Resistant Bacteria: Design, Spectroscopic Characterization and Computational Modelling
  • Bioanalystical Molecular Upconversion (BUC)
  • Bioanalytical Molecular Upconversion (BUC)
  • Design and preparation of novel lanthanide and nano-particle based fluorescent tools for real time monitoring of Beta-lactamase
  • Development of Photoacoustic Probes for Dynamic Sensing of Aging-Related Radical Species
  • Development of Small-Molecule Probes for Simultaneous Profiling of Multiple Free-Radical Evolutions in Bacterial Pathogenesis
  • Engineering of Gut Bacteria Exosome Vesicles for Diet-guided Gastrointestinal Theranostics
  • Enzyme Activity-Based Small Molecule Probes for Selective Identification of Drug Resistant Bacteria
  • Enzyme Triggered Covalent Cross-Linking of Upconversion Nanoplatform for Localized Tumor Imaging and Treatment
  • Hydrogen Bonding Interaction Between Antibiotics and Peptide Precursors on Bacterial Surfaces: An Investigation Using Single-Molecule Fluorescence Detection Techniques
  • Intelligent Photonic Tunable Nanophosphors: Recomposition and Storage of Sunlight for Enhanced Photosynthesis
  • Multifunctional Antimicrobial Peptide Conjugated Nanosensor towards Real-Time Identification and Simultaneous Capture of Toxic Bacterial Lipopolysaccharide
  • NIR Light Absorbing Lanthanide-Doped Upconversion Nano-conjugates Towards Enhanced Inactivation of Tumor Resistance
  • NIR Light Responsive Photon-Converted Nanocrystals AsOptical Contrast Agents For Hybrid Photoacoustic/OpticalCoherence Tomography (PAT/OCT) (NAM/16001)
  • Nanoscale Energy Transfer for Optoelectronic Display and Molecular Sensing
  • Photoactive and Biodegradable Inorganic Nanoparticle Conjugates and Their Applications in Bioluminescent Imaging
  • Singapore-Paris Chemical Biology Workshop
  • Specific Membrane Enzyme Reporters for Real-Time Imaging of Therapeutic Pathological Invasion
  • Unique Optogenetic Strategy for Dynamic Regulation of Signaling Pathways through NIR Light Converted Nano-Platform
Selected Publications
  • Ai, XZ; Lyu, LN; Zhang, Y; Tang, YX; Mu, J; Liu, F; Zhou, YX; Zuo, ZH; Liu, G*; Xing, BG*. (2017). Remote Regulation of Membrane Channel Activity by Site-Specific Localization of Lanthanide-Doped Upconversion Nanocrystals. Angewandte Chemie International Edition, 56(11), 3031-3035, Featured as "BackCover", "X-MoL".
  • Ai, XZ; Ho, CJH; Aw, J; Attia, ABE; Mu, J; Wang, Y; Wang, XY; Wang, Y; Liu, XG; Chen, HB; Gao, MY; Chen, XY; Yeow, EKL; Liu, G*; Olivo, M*; Xing, BG*. (2016). In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics. Nature Communications, 7, 10432, Highlighted in "X-MoL" and "ScienceNet".
  • Mu, J; Liu, F; Rajab, MS; Shi, M; Li, S; Goh, C; Lu, L; Xu, QH; Liu, B; Ng, LG; Xing, BG*. (2014). A Small-Molecule FRET Reporter for the Real-Time Visualization of Cell-Surface Proteolytic Enzyme Functions. Angewandte Chemie International Edition, 53(52), 14357-14362.
  • Abbas, A; Xing, BG*; Loh, TP*. (2014). Allenamides as Orthogonal Handles for Selective Modification of Cysteine in Peptides and Proteins. Angewandte Chemie International Edition, 53(29), 7491-7494.
  • Min, YZ; Li, JM; Liu, F; Yeow, EKL*; Xing, BG*. (2014). Near-Infrared Light-Mediated Photoactivation of a Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging by Upconversion-Luminescent Nanoparticles. Angewandte Chemie International Edition, 53(4), 1012-1016.

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