|Prof Chen has a diverse research background, including animal drug studies, human neuropsychological research and cognitive rehabilitation. She has applied Positron Emission Tomography (PET) to study individuals with post-concussion sequelae from mild traumatic brain injury and olfaction in Alzheimer’s Disease, and has been involved in functional Magnetic Resonance Imaging (fMRI) research examining language processing, executive functions, and affective memory in healthy and clinical populations (e.g. stroke, anxiety, schizophrenia, dementia), as well as, assessing neural systems used in motor timing/timing perception in patients with Parkinson's Disease. Her main research interests are to investigate underlying neural substrates involved in higher cognition in the cerebellum, as well as changes in cognitive processes in healthy aging and dementia through the application of neuroimaging techniques, such as fMRI, diffusion MRI,Transcranial Magnetic Stimulation (TMS), and most recently electroencephalography (EEG). The goal of her research is to apply these paradigms to study and to develop neuroimaging markers in the cerebro-cerebellar circuitry for clinical groups, and to further understand the processes of neurodevelopmental (e.g. schizophrenia, dyslexia, autism) and neurodegenerative (e.g. dementia, healthy aging) conditions that would be informative to evidence-based interventions.|
A recent research development in her lab, the Clinical Brain lab, is focusing on the Neuroscience of Learning and Education. In particular, their lab is investigating the neurophysiological changes in aging neuroscience for learning in language, memory and executive control networks. This allows development of neuromodulation techniques to optimize and/or enhance brain functions for learning. They are also developing research in understanding the effects of emotion on cognition and self-regulation with the use of neuroimaging
- Archer, J. A., Lee, A., Qiu, A., #Chen, S-H. A. (2018). Working memory, age and education: A lifespan fMRI study. PLoS ONE, 13(3), e0194878.
- D. K. Prasad, L. Shijie, S.-H. A. Chen, C. Quek. (2018). Sentiments Analysis Using EEG Activities for Suicidology. Expert System With Applications, 103, 206-217.
- Monika Sobczak-Edmans, Yu-Chun Lo, Yung-Chin Hsu, Yu-Jen Chen, Fu Yu Kwok, Kai-Hsiang Chuang, Wen-Yih Isaac Tseng, SH Annabel Chen. (2018). Cerebro-Cerebellar Pathways for Verbal Working Memory. Frontiers in human neuroscience, 12.
- *Heng, G.J., Wu, C.Y., Archer, J.A., Miyakoshi,M., Nakai, T., #Chen, S.H.A. (2017). The role of regional heterogeneity in age-related differences in functional hemispheric asymmetry: an fMRI study. Aging Neuropsychology and Cognition, 9, 1-24.
- Z. H. Derric Eng, Y. Y. Yick, Yu Guo, Hong Xu, Miriam Reiner, T. J. Cham, SH Annabel Chen. (2017). 3D faces are recognized more accurately and faster than 2D faces, but with similar inversion effects. Vision Research, 138, 78-85.