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Research Categories

Faculty This site

Interface of Biology & Engineering (Engineering in Biology)

Name	Research Interests
Asst Prof Ali Gilles Tchenguise Miserez	Structural properties of biological materials from the macro-scale to the nano-scale Abrasion and wear mechanisms of non-mineralized biocomposites and of biominerals Elastomeric and structural properties of oviparous egg capsules materials Protein chemistry of sclerotized hard-tissues from marine organisms, such as Cephalopod Single-molecular force spectroscopy of structural and elastic proteins Underwater adhesion mechanisms of adhesive proteins Bio-fouling Advanced Metal/Ceramic composites Experimental Fracture Mechanics
Dr Andrzej Stefan Sluzek	A/Prof Andrzej Sluzek's areas of expertise are machine vision, intelligent robotics, and digital systems. His recent research works focus on visual information retrieval using machine vision techniques, implementation of vision-based sensory devices and gated imaging systems.
Asst Prof Ang Wei Tech	- BioRobotics / Bio-Mechatronics - Rehabilitation Engineering - Assistive Technology - Robotic Microsurgery - Robotic Cell Micromanipulation
Asst Prof Arvind Rajendran	Arvind's research interests are in adsorption and chromatography. His focus is on using supercritical fluids as eluents for large scale chromatographic separations, such as the simulated moving bed (SMB) and preparative chromatography, applied to the separation of pharmaceutically active enantiomers. His interests and specializations include adsorption of supercritical fluids, swelling of polymers in supercritical media and gas separation using rapid pressure swing adsorption (PSA) processes.
Assoc Prof Bertil Schmidt	- High Performance Computing - Bioinformatics - Computational Sciences - Reconfigurable Computing - GPGPU
Asst Prof Bjoern Holger Neu	Dr. Neu's areas of expertise are Biophysics and Biorheology. His research work focuses on the stabilization and destabilization of blood and its clinical significance in diseases, blood cell mechanics, cell interactions with biomaterials and the fabrication of multifunctional nano- and microcapsules for biotechnological applictions.
Assoc Prof Cai Yiyu	Prof CAI's areas of expertise are Interactive, Digital & Creative Media, and Computational Bio & Medical Sciences. His current research works focus on 3D Digital Geometry Processing, Immersive Virtual Reality, Computer-aided Design, Protein Docking, Cellular Confocal Imaging and Visualization, Computer-assisted Cardiovascular Intervention, and 1st Phase Drug Clinical Trial Design. He has been active in research and development on 3D and Intractive Bio Arts and Games.
Assoc Prof Chan Bee Eng, Mary	Dr Chan-Park has interest and expertise in nanoimprint, micro- and nano-patterning, biomaterials, tissue engineering and carbon nanotubes. She has published more than 80 hournal papers and holds more than 15 patents/patent applications in these areas. She has supervised more than 12 PhD students and 15 postdoctoral fellows.
Asst Prof Chan Chi Chiu	His research areas are optical fiber sensing system, fiber Bragg grating device, fiber optics chemical sensors, photonics crystal fiber biosensor, digital signal processing, such as artificial neural network, fuzzy logic, genetic algorithm, wavelet, etc., on smart structures, fiber optics chemical and biomedical sensing areas.
Assoc Prof Chan Vincent	Understanding the biophysical properties of cells on biomaterials is essential for designing new tissue regeneration processes and for developing new biomedical devices. Our main objective is to reveal the synergistic interplay between biochemical, physical and mechanical signals in the regulation of cell adhesion, regenerations and recovery on biomaterials or extracellular matrix (ECM). Integrative bio-analytics are critical to our research. Using functional microscopy, optical tweezers and atomic force microscopy, we examine the biophysical dynamics of cell regeneration, biomechanics of membrane and dynamic adhesion of bacteria. We will devise important design principles for engineered tissue equivalents, bio-inspirational materials and anti-microbial devices. I have been working in the following research topics during the last 9 years at Nanyang Technological University: i) Biophysical Dynamics of Cell Regenerations ii) Biophysical Mechanics of Membrane iii) Development of Integrative Biophysical Instrumentation
Asst Prof Chang Wook, Matthew	Prof. Chang's areas of expertise are systems biology, metabolic engineering, and engineering biology. His current research works focus on elucidating genetic regulatory networks and relevant cellular mechanisms in bacteria. The research group website: http://www.changlab.com/
Assoc Prof Chen Wei Ning, William	1. Mechanism of liver diseases associated with HBV infections by molecular biology and virology techniques for novel antiviral drug targets; 2. Proteomics with LC-MS/MS analysis in metabolic/pharmaceutical engineering, particularly on cellular response to chiral drugs for biomarker identification.
Asst Prof Chen Yan	Deployable Structures, Design, Analysis and Control Cell mechanics Mechanism Theory Morphing Structures Re-configuration and Multi-configuration Structures Computational Mechanics Topology Optimisation
Asst Prof Cheong Siew Ann	Asst Prof CHEONG Siew Ann's areas of expertise are in computational physics, complex system dynamics, and bioinformatics. He is currently working on the development of self-consistent stochastic boundary conditions for ab initio and molecular dynamics simulations, methods to accelerate Monte Carlo simulations and high-dimensional optimization. He is also interested in developing automatic coarse-graining algorithms to perform data-driven identification of effective degrees of freedom in financial markets, very-large-scale computer simulations. He is also working on applying ideas from the Renormalization Group in statistical physics to the mining of very-large-scale databases.
Assoc Prof Chian Kerm Sin	Prof Sandy Chian's areas of expertise are polymer chemistry, medical implants, and tissue engineering. His current research works focus on synthesis of degradable polymers, tissue engineering and scaffold fabrication technology.
Assoc Prof Chou Siaw Meng	Assoc Prof Chou Siaw Meng's research interests include biomechanics and buckling of cold-formed thin-walled structures. His current research work includes biomechanics of the hand, bone, tendon, shoulder, spine, knee as well as design of medical devices (surgical instruments, implants, etc.).
Assoc Prof Chu Jian	Dr Chu's area of expertise includes labotrory and in-situ testing, soil properties, ground improvement, land reclamation, and waste utilisation. My research focus areas at the present are: (1) Instability behaviour of granular soil; (2) Innovative ground improvement methods including the use of microbial technologies; (2) Waste utilisation; and (4) Disaster mitigations.
Assoc Prof Chua Leok Poh	My research interest is in Bio-fluid engineering espcially on the numerical simulations and measurements (Laser Doppler Anemometer and Particle Image Velocimetry) of the Coronary Bypass Grafting and the Artificial Heart Pumps (both Centrifugal and Axial blood pumps). Furthermore, the design of sleeve connector for the prolong patency of the Coronary Bypass Graft at the distal anastomosis. In addition, I am also interested in turbulent flow measurements using both hot-wire and cold-wire probes in various jet configulations, confined jet and low speed flow measurements.
Asst Prof Domenico Campolo	His research interests include mechatronic technologies with application to the new emerging fields of Phenomics and Neuro-Developmental Engineering, in both animal and human models; biomimetic microrobotics, including: design, fabrication, development and control of biologically inspired smart actuators and sensors.
Asst Prof Duan Hongwei	His current research is focused on two major areas including nanomaterials engineering and biomedical nanotechnology. The goal of this work is to develop new technological platforms for early detection and targeted therapy of major human diseases such as cancer. Ongoing projects in his group include semiconductor quantum dots for live cell imaging and biomarker profiling, multifunctional nanoparticles for integrated cancer imaging and therapy, self-assembled nanostructures for disease-targeted drug/gene delivery and ultrathin films based arrays for ultrasensitive biodetection.
Assoc Prof Erry Gunawan	Assoc Prof Erry Gunawan's areas of expertise are in digital wireless communications systems, powerline communications, channel coding, spread-spectrum communications and CDMA, OFDM, MAC protocol and radio-locations. His current research works focus on the applications of UWB for RADAR and medical imaging and MIMO wireless communications.
Prof Jimmy Pingkwan Tam @ James P Tam	His research work has focused on the design and development of therapeutics, particularly biologics and immunologics of anti-infectives and synthetic vaccines. http://jptam.sbs.ntu.edu.sg/
Asst Prof Kai Tang	Dr. Kai Tang's area of expertise is biological applications of mass spectrometry. His current research works focus on protein experssion profiling, biomarker discovery and clinical diagnostics of thalassemia diseases, one of the most common genetic diseases in Southeast Asia and around the world. He is also working on developing novel methods for pathogen identification and protein structure elucidation.
Assoc Prof Karl Wolfgang Mueller-Wittig	Associate Professor Dr. Wolfgang Mueller-Wittig areas of expertise are computer graphics, real time rendering, Virtual & Augmented Reality, and GPGPU. Current research work focus on the use of GPU for high performance computational biology (e.g., bio-sequence alignment). He is also involved in the SMART-CENSAM (Centre for Environmental Sensing and Modeling) project and responsible for the development of a visualization platform for interactive evaluation and exploration of dynamic environmental models. Further research include cultural heritage (e.g., Virtual Peranakan) and the generation of new learning environments using interactive & digital media (e.g., Augmented Reality Chinese Language Learning Game, Virtual NanoTechZoo, Augmented Physics Lab).
Prof Kjelleberg Staffan Lars Aake	Kjelleberg is internationally recognized for his studies of bacterial adaptive responses, signalling based communication between bacteria, bacterial biofilm biology, and chemically mediated interactions between bacteria and marine sessile organisms. His research approach includes molecular based studies of the mechanisms by which bacteria respond to prevailing conditions as well as environmental genomics of the biodiversity and function of natural microbial consortia. Kjelleberg has published more than 240 original papers in international refereed scientific journals and 30 books or book chapters. On the basis of strong collaborative research across microbiology, marine ecology and chemistry, and applied studies of the strategies employed by bacteria to build biofilms and communicate, substantial intellectual property has been established and utilized in biotechnology industries. Kjelleberg and his colleagues at the CMB also serve as a major research provider to several companies and organizations, including the Australian based Environmental Biotechnology Cooperative Research Centre.
Assoc Prof Koh Tong San	Dr. Koh's current research interests include biomedical engineering and semiconductor quantum structures.
Assoc Prof Kwoh Chee Keong	Development of a Computer Prediction System For Rational Design Of HLA-Based Peptide Vaccine; Data Mining and Analysis on Infectious Disease Heterogeneous Multi-Core Systems For Bioinformatics Constrained Optimzation for Bioinformatics Protein Interaction Network Analysis Using Graph Mining Approaches
Asst Prof Lee Kijoon	His research interest is over a broad area of interaction of light with human tissue, with the application in medical imaging in mind. Main research field is diffuse optical tomography (DOT) and its variants such as fluorescence diffuse optical tomography (fDOT) and bioluminescence tomography (BLT). He is experienced in both instrumentation and numerical image reconstruction, and is actively performing research on building a clinical imaging device for breast cancer screening.
Assoc Prof Liao Kin	Nano-mechanics and nano-composites, mechanics of molecules and cells, tissue engineering, and molecular simulation of living and nonliving systems.
Assoc Prof Lim Chu Sing	His research interests include Biosensor Technologies for DNA & Etiological Agents, Bio-Rapid Prototyping and Tooling, Medical Devices Technologies, Testing and Development, Monitoring Mutation in Progress and Combinatory Drug Efficacy Systems for Pharmaceutical Biomolecule Investigations, and Biomaterials. Dr Lim expertise in Medical Devices has also resulted in a novel respiratory stent which was implanted in a patient with an uncommon genetic disorder. Two of his work has been licensed to two biomedical companies for commercialization. He teaches undergraduate and postgraduate students in stage-gate for medical devices, surgical assist technologies, biomedical physics, and other aspects of biosafety and bioethics.
Asst Prof Lim Sierin	Her research focuses on development of hybrid nanobiomaterials by utilizing protein engineering. Understanding assembly of various protein-based nanocapsules and applying them as molecular carriers in medicine are her primary interests.
Assoc Prof Lin Feng	Dr Lin's research interest includes bioinformatics, biomedical imaging and visualization, high-performance computing. Currently active funded projects: A-Star/BMRC - Creating an In Vivo Navigational Cellular Fluorescence Imaging System with Dynamically Optimized Endomicroscopy, AcRF - Real-time Diagnostic Endomicroscopy, A-Star/SERC - Collaborative Creation and Application of Interactive Digital Media over the Internet, AcRF - Cellular Fluorescence Imaging with Endomicroscopy, AcRF - Dynamically Adaptable Neurocomputer and Its Application to Recognition of Steroid Hormone Response Elements, SingHealth Foundation Development of a Real-time Fluorescence Endoscopy Diagnostic System for the Early Detection of Oral and Bladder Cancers, NTU/BPE Cluster SEED Funding - Gene Expression Profiling with Oligonucleotide Microarray Technology; and some completed funded projects: SCE ER Lab Research Programme Grant DNA Chip Design Programme, BMRC&NMRC Joint Research Fund - Elucidation of Expression Profiles of Genes in Alpha-fetoprotein Positive and Alpha-fetoprotein Negative Hepatocellular Carcinoma by cDNA Microarray Analysis, AcRF - Design and Simulation of Artificial Bone Implantation, NMRC Research Fund -Nasopharyngeal Carcinoma: 3D Imaging for Staging and Treatment Planning, AcRF - Design and Development of Bio-medical Devices Using Rapid Prototyping (RP) Techniques, AcRF - Real-time Dynamic Simulation, MOH & Singapore Totalisator Research Fund - Transforming Medical Ultrasound Scanning into 3-Dimensional Real-time Organ Imaging to Aid Clinical Diagnosis.
Asst Prof Liu Quan	• Biophotonics • Biomedical optical spectroscopy and imaging • Non-invasive medical diagnostics • Biomedical instrumentation • Computer simulation of electromagnetic wave in tissue
Assoc Prof Luo Qian Kathy	Prof. Luo's areas of expertise include genetic and protein engineering, design and application of fluorescent-based biosensor in living cell analysis, apoptosis, cell cycle regulation and nanomization using supercritical CO2 method. Her current research works focus on three projects: 1. Drug discovery: Using a biosensor-based high throughput assay to discover novel anti-cancer drugs from Chinese herbal medicines. 2. Pharmaceutical engineering: Studying the molecular mechanisms and pharmacokinetics of drug candidates using cancer cell lines and animal models. 3. Nano-medicine: Using nanotechnology to enhance the solubility and bioavailability of the drug compounds and evaluating the resulting particles using a Caco-2 cell monolayer model and animal models.
Asst Prof Meena Kishore Sakharkar	Computational biology, BioInformatics and Biotechnology with special focus on - Biological databases, Genome design and architecture, comparative genomics, Drug discovery, Combination therapy for treatment of bacterial infections.
Prof Narasimhan Sundararajan	Aerospace control, machine learning, Computational Intelligence, neural networks and applications. 1. Neural Networks Learning Algorithms Minimal Resource Allocation Network: A sequential learning algorithm for realizing a minimal radial basis function network (RBFN), referred to as Minimal Resource Allocating Network (MRAN). With the growing and pruning strategy, the MRAN algorithm can implement a more compact network structure, resulting in fast on-line learning. The MRAN algorithm is successfully applied in the areas of function approximation, time series prediction, nonlinear system identification and pattern recognition. Yingwei Lu, N. Sundararajan, P. Saratchandran, ?A Sequential Learning Scheme for Function Approximation using Minimal Radial Basis Function Neural Networks?, Neural Computation, MIT Press, USA, Vol. 9, No. 2, pp. 461-478, February 1997. Adaptive Flight Control Until the later part of 1940's and early 1950s flight control research was aimed at providing pilot relief capabilities, mainly in the form of auto-pilots. With the advent of high performance aircrafts, it become evident that controllers were required to bring the aircrafts within certain specified operating envelop that would increase the pilots capabilities for controlling the aircrafts. Due to stringent requirements and complexities of the modern flight control system, it is difficult to estimate the nonlinearities accurately. The performance of conventional controller will be poor under severe nonlinearities. The research deals with the new design development of adaptive and fault tolerant control systems using neural network methodologies. Conventional aircraft, helicopters and unmanned aerial vehicles are considered. The aim of the research area is the design of adaptive flight controllers such that the aircraft can even under severe fault and disturbances. The application of controllers to linear and nonlinear models was investigated.
Asst Prof Olga Sourina	Prof Sourina's areas of expertise are computer graphics, virtual reality, data mining, and orthopedic surgery simulation. Her current research works focus on visual haptic-based molecular docking, visual data mining, processing and analysis of brain responses to external stimuli.
Assoc Prof (Adj) Philip Wong En Hou	1. Cellular Therapy and devices used for cell transplantation 2. Implantable Medical Devices 3. In-vivo imaging of disease, particularly cardiovascular related 4. Materials used for implantable devices
Asst Prof Poh Chueh Loo	Asst Prof Poh research interests include biomedical image processing and visualization, Information Technology for Healthcare and synthetic biology. His current research works focus on image processing and visualization related to MR imaging and modeling of standard biological parts.
Assoc Prof Shu Jian Jun	Associate Professor Jian-Jun SHU's areas of expertise are Thermo-Fluid Mechanics, Applied Mathematics and Biophysics. His current research works focus on Nano/Micro Fluids, DNA/Protein Modelling and Mathematical Strategame Theory.
Assoc Prof Sourav Saha Bhowmick	Associate Prof Sourav S Bhowmick's areas of expertise are database technology and data mining. His current research works focus on social network mining, tree and graph structured data mining, XML data management, graph query processing, and system biology data management focusing on predictive modeling and comparison of molecular networks, and multi-target drug therapy.
Prof Subramanian Venkatraman	Research is focussed on the applications of polymeric biomaterials in medicine. In particular, research areas include biodegradable stents, injectable drug delivery systems and gene delivery. Controlled release of drugs to the eye and the cardiovascular system are the primary end applications. Cancer therapy using "stealth" particles also forms a significant component of the research activities.
Assoc Prof Sunita Chauhan	Medical/surgical robotics, Computer Assisted/Integrated Surgery, Bio-medical Instrumentation, Robotics, Mechatronics, Sensors/Transducers, Ultrasound in Medicine (Diagnostic, Therapeutic, Surgical), Signal/Image Processing, Bio-mechanics (hard and soft tissue), Tissue characterization, Real-time monitoring and feedback.
Asst Prof Surajit Bhattacharyya	Structural Dissection of Scaffolding Protein and Its Interactions with Kinases SAM-SAM Interactions in MAPKKK Activating Ste11/Ste50 Complex Interactions of Integrin Tails with Effector Proteins Designed Peptide Antagonists against Endotoxin: A structure-based approach to develop antisepsis and antimicrobial drugs. Structure and Activity of Cathelicidin Family of Antimicrobial and Antiendotoxic Peptides.
Asst Prof Sze Chun Chau	Assistant Professor Sze Chun Chau's basic research interest lies in bacterial gene regulation and communication. Specifically, the complexity of gene regulatory circuits and inter-species communication are being investigated using biofilms, i.e. surface-associated and structured bacterial communities, as model systems. The two systems that she is currently working on includes (a) intestinal microbiota and (b) Legionella pneumophila in interaction with its amoebic host. On the second level, she is interested in the application and domestication of biofilms in medical, industrial and environmental contexts. Eradication of biofilms has been the primary force driving applied research in this field, but exploiting (rather than fighting) biofilms has great potential that awaits exploration.
Asst Prof Tan Nguan Soon	My research centered on peroxisome proliferators-activated receptors (PPARs) signaling in several complex processes which are of extreme clinical relevance. Wound repair Effective wound repair requires the interactions among immune cells, keratinocytes, fibroblasts and endothelial cells. Mesenchymal-epidermal interactions play a crucial role in skin homeostasis and tissue repair. My laboratory research concerns the crosstalk of signaling pathways invoked during barrier and skin repair, especially in obese and/or diabetic conditions. Carcinogenesis Many evidences clearly support a tumor-promoting role of inflammation in the development and progression of epithelial skin cancer. Tumor-promoting microenvironment resembling the wound environment is indispensable for tumor formation and progression. PPARs play important role in carcinogenesis. My laboratory is interested in the impact of tumor microevironment on the PPAR activity.
Prof Tan Ooi Kiang	Dr Tan has been actively involved in the Sensors, Actuators, and Smart Materials as well as the Nanoelectronics and Silicon Technology research groups in the Microelectronics Center, School of EEE. His research focus is in the area of microelectronics and nanoelectronics materials and devices design for electronics, bio-medical, functional sensor and actuator applications. These includes the synthesis, fabrication and characterization of semiconductor & ferroelectric nano-structured metal oxide and composite materials, thick and thin film functional devices; solid-state reaction high-energy ball milling and sol-gel processing, ICP-CVD nano-technology; bio-chemical sensor and actuator applications; and silicon-based device fabrication & integration. Dr Tan is the principal investigator for 13 research projects with a total funding of $3.8 millions (not including scholarship funding for students) mainly in the areas of chemically-activated nano materials and functional devices. Currently, he leads a 20-member research team of research staff and students; and collaborates with many colleagues, both locally and internationally.
Assoc Prof Tjin Swee Chuan	Swee Chuan Tjin's research interests are in fibre optic sensors, biomedical engineering and biophotonics.
Asst Prof Vitali Zagorodnov	Prof Zagorodnov?s areas of expertise are signal and image processing. His current research works focus on brain structural and functional imaging.
Asst Prof Wan Man Pun	Prof Wan's areas of expertise are aerosol sciences, building environmental quality and catalytic combustion. His current research works focus on transport of expiratory aerosols in indoor environments and infectious disease transmission, ultrafine particle dynamics, mass transfer and chemical kinetics in catalytic oxidation systems.
Asst Prof Wang Dongan	Assistant Professor Wang Dongan's research interests include: (1) Functional biomaterials for tissue engineering; (2) Stem cells for engineered tissue regeneration; (3) Gene delivery for engineered tissue regeneration; and (4) Tissue-biomaterial integration.
Prof Wen Changyun	Prof Wen's areas of expertise are Adaptive Control,Switching and Impulsive Systems,Modeling and Design of Steam Ejector Based Air-Conditioning Systems,Modeling, Monitoring, Control and Optimization of Water Distribution Networks, Iterative Learning Control,Control of Nano-Systems, Control of Biomedical Systems,Optical signal Processing,Active Vision and Its Applications,Chaos-Based Secure Communication Systems,Robust Control,2-D Systems and Image Processing. Currently his current research works focus on Adaptive Control,Modeling and Design of Steam Ejector Based Air-Conditioning Systems,Modeling, Monitoring, Control and Optimization of Water Distribution Networks, Control of Nano-Systems, Control of Biomedical Systems,Chaos-Based Secure Communication Systems.
Assoc Prof (Adj) Wu Ping	Dr. Wu Ping's expertise is in Materials Chemistry, and Biological Chemistry. His current research works focus on new materials for alternative energy, green materials, biomaterials and advanced electronic materials.
Asst Prof Xue Can	Development of novel plasmonic nanomaterials for solar energy applications (photovoltaics and photocatalysis) using anisotropic metallic nanostructures that exhibit unique surface plasmon resonance properties in the visible and near-IR region.
Assoc Prof (Adj) Yang He	Prof Yang's areas of expertise are Genomic data analysis and integration, Target gene discovery, and Bioinformatics tool development. His current research focuses are on 1) Development of experimental benchmarking for evaluation of statistical analysis methods 2) Integration of various genomics data for gene expression, copy number variation, miRNA expression, TF binding sites, and pathway information 3) Application of computational methods for target gene/activated pathway discovery in Stem Cell Research, Cancer Cell Research and Systems Immunology 4) Development of bioinformatics tools
Asst Prof Zbynek Bozdech	My research focuses on regulatory mechanisms that are associated with the progression of the complex life cycle of human malaria parasites, Plasmodium species. The research activities can be divided into three major objectives (i) Characterizations of transcriptional regulation in Plasmodium. In these studies we conduct genome-wide transcriptional profiling of field isolates and chemical genomics analyses of the laboratory strains. The main goal of these studies is to identify transcriptional regulation that controls parasites virulence as well as responses to drug therapies. (ii) Quantitative proteomics of the Plasmodium intraerythrocytic developmental cycle. The main objective these studies is to characterize protein abundance profiles as well as the pattern of posttranslational modification associated with the progression of the Plasmodium erythrocytic development. These studies are conducted in the proteome-wide manner using the two dimensional gel electrophoresis approaches. The main objective is to identify regulatory elements of Plasmodium translational machinery as new therapeutic targets for human malaria. (iii) Epigenetic regulation of transcriptional control in Plasmodium parasites. Using a chemical genetic approach we characterize a role of Histone Deacetylases (HDAC) in the transcriptional regulation of the Plasmodium life cycle. Using these approaches we attempt to analyze the histone code in Plasmodium and its role in parasite growth and development. Simultaneously we evaluate a potential of HDAC inhibitors as new malaria chemotherapeutics.

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