Academic Profile

Academic Profile

Asst Prof Tan Meng How

Assistant Professor, School of Chemical and Biomedical Engineering
Research Scientist

Email: mh.tan@ntu.edu.sg
Asst Prof Tan Meng How

Biography
Meng How Tan has been with the School of Chemical and Biomedical Engineering since 2014 and also has a joint appointment with the Genome Institute of Singapore (GIS), A*STAR. He studied Mechanical Engineering and Economics at the University of California – Berkeley from 1998 to 2001 as well as Aeronautics at California Institute of Technology (Caltech) from 2001 to 2002 on a Singapore Government Overseas Merit Scholarship. He was also awarded the Donald Wills Douglas Fellowship at Caltech. Subsequently, he studied Biomedical Engineering at NTU from 2003 to 2004 and was awarded the Siemens Book Prize and the Professional Engineers Board Gold Medal before embarking on his doctoral studies with Harley McAdams and Lucy Shapiro from 2004 to 2009 at Stanford University, where he received his Ph.D. in Developmental Biology. His doctoral studies was funded by a National Science Scholarship from A*STAR. He continued on at Stanford for his postdoctoral training, first with Mylene Yao and Wing Hung Wong (2009-2010) and then with Jin Billy Li (2011-2013). Now, he is excited to be a faculty member in NTU, working with and training future generations of scientists and engineers.
Research Interests
Meng How’s overall research interests are in systems biology and genomics. He leverages on cutting edge technologies, high throughput approaches, and engineering principles to investigate regulatory networks in biology. He studies both prokaryotes (e.g. bacteria) and eukaryotes (including human) and is interested in both transcriptional and post-transcriptional networks.
Current Projects
  • Genetic Regulatory Networks in Development and Human Diseases
  • Improving the efficiency of CRISPR-Cas technologies for therapeutic applications
  • Investigating the critical role of RNA editing during Xenopus development
Selected Publications
  • Tan M.H., K.F. Au, D.E. Leong, K. Foygel, W.H. Wong, and M.W.M. Yao. (2013). An Oct4-Sall4-Nanog network controls developmental progression in the pre-implantation mouse embryo. Molecular Systems Biology, 9, 632.
  • Tan M.H., K.F. Au, A.L. Yablonovitch, A.E. Wills, J. Chuang, J.C. Baker, W.H. Wong, and J.B. Li. (2013). RNA sequencing reveals diverse and dynamic repertoire of the Xenopus tropicalis transcriptome over development. Genome Research, 23, 201–216.
  • Ramaswami G., Lin W., R. Piskol, M.H. Tan, C. Davis, and J.B. Li. (2012). Accurate identification of human Alu and non-Alu RNA editing sites. Nature Methods, 9(6), 579-581.
  • Lin W., R. Piskol, M.H. Tan, and J.B. Li. (2012). Comment on “Widespread RNA and DNA sequence differences in the human transcriptome”. Science, 335(6074), 1302.
  • Tan M.H., J.B. Kozdon, X. Shen, L. Shapiro, and H.H. McAdams. (2010). An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(44), 18985-18990.

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