Academic Profile

Academic Profile

Assoc Prof Kunn Hadinoto Ong

Associate Professor, School of Chemical and Biomedical Engineering

Email: kunnong@ntu.edu.sg
Phone: +65 65148381
Office: N1.2 B2 31
Assoc Prof Kunn Hadinoto Ong

Biography
Assistant Professor Kunn Hadinoto Ong joined the School of Chemical and Biomedical Engineering in 2007. He received his bachelor degree in chemical engineering from the University of Washington (Seattle, USA) in 2000 and his doctoral degree also in chemical engineering in 2004 from Purdue University (West Lafayette, USA). His research interests are in the area of particle technology with an emphasis on its applications in sustainable pharmaceutical manufacturing, inhaled delivery of nanomedicines, and nutraceutical food product processing
Research Interests
Research interests:

1) Development of sustainable preparation methods of solid dosage form of nanopharmaceuticals

2) Inhaled delivery of nano-antibiotics for chronic lung infection therapy against Pseudomonas aeruginosa biofilm

3) Development of nutraceutical food products (e.g. probiotics, medicinal herbs)

4) Lipid-polymer hybrid nanoparticles as a new generation drug delivery platform

5) Flow behaviors of powders in pharmaceutically relevant processes (e.g. crystallizer, granulator, dryer)
Current Projects
  • Cambridge Centre for Carbon Reduction in Chemical Technology (C4T)- Carbon Abatement in the Petroleum Industry: A Control and Optimisation Research Network (CAPRICON) (IRP3.4)
  • Cradle-to-Gate Life Cycle Assessments of API Solid Dosage Form Manufacturing Aimed towards the Development of Green Pharmaceutical Excipient Selection Guide
  • Development of Vaccine-Containing Thermostable Nanocapsules Aimed at Reducing the Cold-Chain Dependence of Vaccine's Storage and Transportation
  • New Research Initiatives in Chemical and Bioengineering Areas
  • Novel approaches for biometric systems
  • Sustainable Manufacturing of Stable Amorphous Drug Nanoplex as a New Nanomedicine Formulation Strategy
Selected Publications
  • W.S. Cheow, K. Hadinoto. (2013). Biofilm-Like Lactobacillus rhamnosus Probiotics Encapsulated in Alginate and Carrageenan Microcapsules Exhibiting Enhanced Thermotolerance and Freeze Drying Resistance. Biomacromolecules, 14(9), 3214-3222.
  • Cheow WS, Hadinoto K. (2012). Green Amorphous Nanoplex as a New Supersaturating Drug Delivery System. Langmuir, 28(15), 6265-6275.
  • Wang Y, Kho K, Cheow WS, Hadinoto K. (2012). A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles. International Journal of Pharmaceutics, 424(1-2), 98-106.
  • W.S. Cheow, K. Hadinoto. (2011). Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles. Colloids and Surfaces B: Biointerfaces, 85, 214-220.
  • W.S. Cheow, M.W. Chang, K. Hadinoto. (2010). Antibacterial efficacy of inhalable levofloxacin-loaded polymeric nanoparticles against E. coli biofilm cells: The effect of antibiotic release profile. Pharmaceutical research, 27(8), 1597-1609.

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