- Biosynthetic Mechanism of Antitumor Enediyne Natural Products
- Design and Synthesis of Functional C-di-GMP Deriatives as Biological Probes and Antibacterial Agents
- Discovery and engineering of nitrile oxidoreductase as biocatalysts for nitrile reduction
- Structure and Function of the Polyketide Synthase in Enediyne Biosynthesis
- Structure and function of novel antibiotic target fimX in apportunistic pathogen pseudomonas aeruginosa
- Structure and regulation of c-di-GMP signalling proteins in pathogenic bacteria
- Study of the Biosynthetic Mechanism of Salinosporamide A for Developing Novel ProteasomeInhibitors
| Selected Publications | - . K.-H. Chin, Z.-L. Tu, Y.-C. Su, Y.-J. Yu, H.-C. Chen, Y.-C. Lo, C.-P. Chen, G. Barber, M.L.-C. Chuah, Z.-X. Liang and *S.-H. Chou. (2013). Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING. Acta Crystallographica, D69, 352-366.
- Ho, C. L., Chong, K. S. J., Oppong, J. A., Chuah, M. L. C., Tan, S. M., *Liang, Z.-X. (2013). Visualizing the perturbation of cellular cyclic di-GMP levels in bacterial cells.. J. Am. Chem. Soc., 135, 566-569.
- Tan, E., Rao, F., Pasunooti, S., Soehano, I., Liew, C. W., Lescar, J., *Pervushin, K., *Liang, Z.-X. (2013). Solution structure of a small PAS domain in cyclic di-AMP signaling reveals a ligand-binding site. J. Biol. Chem., 26, 11949-11959.
- Sun H, Ho CL, Ding F, Soehano I, Liu X-W, and Liang Z-X. (2012). Synthesis of (R)-Mellein by a Partially Reducing Iterative Polyketide Synthase. J. Am. Chem. Soc., 134(29), 11924–11927.
- Lim, J., Sun, H., Fan, J.-S., Hameed, I. F., Lescar, J., Liang, Z.-X., *Yang, D. (2012). Rigidifying the acyl carrier protein domain of the iterative polyketide CalE8 does not affect its function. Biophysical Journal, 103, 1037-1044.
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