Nanyang Technology University

Academic Profile
Asst Prof Zhang Li-Feng 

Assistant Professor 
Division of Molecular Genetics & Cell Biology 
School of Biological Sciences 
College of Science 



Email: ZHANGLF@ntu.edu.sg
Phone: (+65)63167094 
Office: SBS-02s-58 
Education
  • PhD (Molecular Genetics) Baylor University 2002
  • BSc (Biology) Peking University 1996
Biography
Assistant Professor Zhang Li-Feng is currently in the School of Biological Sciences since 2009. He received his Bachelor degree in Biology from Peking University (P.R.China), and Ph.D. degree in Molecular Genetics from Baylor Univerisity (USA). His research interest is to understand how gene expression is regulated in cell differentiation. In particular, he is interested in roles of epigenomic program and transcription factor circuitry in embryonic stem cell pluripotency.
Research Interests
Dr. Zhang Li-Feng's current researches focus on using X chromosome inactivation as example to study chromatin modifications, non-coding RNAs and embryonic stem cell pluripotency.
Research Grant
  • A*STAR Biomedical Research Council - Singapore Stem Cell Consortium (2009-)
  • Academic Research Fund Tier 1 (2010-)
  • Start Up Grant (2008-)
Current Projects
  • Comprehensive chromosome-wide allele-specific analyses of X chromosome inactivation
  • Functional analysis of teloRNA in ES cell differentiation, X chromosome inactivation and oncogenesis
  • Studies on X chromosome inactivation in wild type and mutant embryonic stem cells
  • Using "2i" approach to establish new female mouse ES cell lines with higher ES cell quality and advanced feature for X chromosome inactivation studies
Selected Publications
  • Lai LT, Lee PJ, Zhang LF. (2013). Immunofluorescence protects RNA signals in simultaneous RNA-DNA FISH.. Experimental Cell Research, 319(3), 46-55.
  • Lingyi Chen, Li-Feng Zhang. (2012). A Balanced Network: Transcriptional Regulation in Pluripotent Stem Cells. Journal of Stem Cell Research and Therapy, , doi:10.4172/2157-7633.S10-004.
  • • Sze Lynn Calista Phua, V. Sivakamasundari, Yu Shao, Xiaohan Cai, Li-Feng Zhang, Thomas Lufkin, and Mark Featherstone. (2011). Nuclear accumulation of an uncapped RNA produced by Drosha cleavage of a transcript encoding miR-10b and Hoxd4. PLoS ONE, 6(10), e25689.
  • Reelina Basu and Li-Feng Zhang. (2011). X Chromosome Inactivation: A Silence That Needs to be Broken. Genesis, 49, 821-834.
  • Zhang, L. F., Ogawa, Y., Ahn, J. Y., Namekawa, S. H., Silva, S. S., Lee, J. T. (2009). Telomeric RNAs Mark Sex Chromosomes in Stem Cells. Genetics, 182(3), 685-98.
Printer-friendly | Send to a friend
DCSIMG