|Zbynek Bozdech holds currently a position as Assistant Professor at the School of Biological Sciences at Nanyang Technological University in Singapore leading a research team investigating molecular aspects of malaria parasite life cycle. In 1990, he has received his masters’ degree in Biochemistry from Charles University in Prague. From here he moved to McGill University in Montréal Canada to start his PhD studies involving protein trafficking in Plasmodium infected erythrocytes. In 1998 he moved to UCSF, where he worked in the laboratory of Joseph L. DeRisi exploring the transcriptome of Plasmodium falciparum using the fast emerging microarray technology. This work has lead to assembly of one of the first P. falciparum microarray and explorations of the global transcription pattern of the P. falciparum intraerythrocytic developmental cycle. In 2004, he moved to the newly forming School of Biological Sciences at NTU, to start his own research group. Presently Dr Bozdech is exploring several molecular aspects of translation and posttranslational regulation associated with the progression of the P. falciparum life cycle. In addition, using several technologies of high throughout genomics and proteomics his group is exploring molecular mechanisms associated with virulence and drug resistance in field strains of P. falciparum and P. vivax.|
- Comparative transcription analysis to identify novel targets for malaria intervention
- Epigenetic regulation of gene expression in human malaria parasites Plasmodium falciparum : new target for malaria drug development
- Exploration of nuclear proteome for chromatin remodelling proteins in the human malaria parasites, Plasmodium falciparum
- Functional genomic analyses of human malaria parasite resistance to artemisinin
- Generation of Novel Malaria-associated Antigens and Antibodies for Rapid Diagnotics Test Kit Development
- Genomic analysis of malaria host parasite interactions
- Identifications and characterizations of molecular factors associated with transcriptional regulation in human malaria parasites, Plasmodium falciparum
- Quantitative Proteomics of the Intraerythrocytic Developmental Cycle of the Human Malaria Parasites Plasmodium falciparum
- Single cell genomics, a new window into malaria parasite physiology and pathogenicity
- Gao X, Yeo KP, Aw SS, Kuss C, Iyer JK, Genesan S, Rajamanonmani R, Lescar J, Bozdech Z, Preiser PR. (2008). Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites. PLoS Pathogens, 4(7), e1000104.
- Kotaka M, Ye H, Alag R, Hu G, Bozdech Z, Preiser PR, Yoon HS, Lescar J. (2008). Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506. Biochemistry, 47(22), 5951-61.
- Llinas M, Bozdech Z, Wong ED, Adai AT, DeRisi JL. (2006). Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains. Nucleic Acids Research, 34(4), 1166-73.
- Silvestrini F, Bozdech Z, Lanfrancotti A, Di Giulio E, Bultrini E, Picci L, Derisi JL, Pizzi E, Alano P. (2005). Genome-wide identification of genes upregulated at the onset of gametocytogenesis in Plasmodium falciparum. Molecular and Biochemical Parasitology, 143(1), 100-10.
- Bozdech Z, Ginsburg H. (2005). Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes. Malar J, 18;4(1), 17.