2006.4 - now Assistant Professor in School of Biological Sciences, NTU
2003.10 – 2006.3 Lee Kuan Yew Fellowship in School of Biological Sciences, NTU
2000.1 - 2003.9 Research Fellow (Wissenschaftlicher Mitarbeiter) in Institute of Theoretical Chemistry
Frankfurt am Main, Germany Biomolecular simulations and dynamics analyse,
cooperated with Prof. G. Stock and Prof. Peter Hamm
1999.1 - 2000.1 Alexander von Humboldt Fellow in Fraunhofer Institute of Integrated Systems and Device
Technology (IISB) Schottkystrasse 10, 91058 Erlangen, Germany cooperated with Prof.
Heiner Ryssel and Dr. Alex Burenkov. Simulation of atoms -solids interaction.
1997.7 - 1999.1 Lecturer , Department of photoelectronics, Shandong Univ. |
Research Fields
1. MD simulation method and data analysis method development.
2. DNA dynamics, DNA ?protein, DNA-counterions interaction study.
3. Peptide, protein folding, unfolding study, specially aimed at folding, misfolding mechanism which could lead to amyloid fibril.
4. RNA dynamics and folding study. |
- Explore Folding Mechanism of RNA, DNA loops : Invention and application of new sample enhancing method for molecular dynamics simulations
- Explore the Intrinsic Disordered Nature of Structures of Human Islet Amyloid Polypeptide and Its Amyloid Formation Mechanism By Combined Computational and Nuclear Magnetic Resonance Study
- Explore the neutralization mechanism of natural small molecule on the toxicity of Aβ Protein aggregation by molecular dynamics simulations
- Processive mechanism in cellulose degradation by cellobiohydrolase
- To Win the War Against H1N1 Influenza A: Breaking Through the Limitations of Significant Side Effects and Resistance of Current Anti-Flu Drugs
| Selected Publications | - Wei L, Jiang P, Manimekalai MSS, Hunke C, Gruber G, Pervushin K, Mu Y. (2013). Extended structure of rat islet amyloid polypeptide in solution. Advances in Experimental Medicine and Biology, .
- Jiang P(s), Li WF(s), Shea JE, Mu YG. (2013). Resveratrol Inhibits the Formation of Multiple-Layered beta-Sheet Oligomers of the Human Islet Amyloid Polypeptide Segment 22-27. Biophysical Journal, 100(6), 1550-1558.
- Chebaro, Y.; Jiang, P.; Zang, T.; Mu, Y. G.; Nguyen, P. H.; Mousseau, N.; Derreumaux, P. (2012). Structures of A beta 17-42 Trimers in Isolation and with Five Small-Molecule Drugs Using a Hierarchical Computational Procedure.. Journal of Physical Chemistry B, 116(29), 8412-8422.
- Tim Lauterbach1, Manoj Manna1, Maria Ruhnow1, Yudi Wisantoso1, Yaofeng Wang, Artur Matysik, Kamila Oglęcka, Yuguang Mu, Susana Geifman-Shochat, Thorsten Wohland, Rachel Kraut. (2012). Weak Glycolipid Binding of a Microdomain-Tracer Peptide Correlates with Aggregation and Slow Diffusion on Cell Membranes. PLoS ONE, 7(12), e51222.
- Kang, C. B.; Bharatham, N.; Chia, J.; Mu, Y. G.; Baek, K.; Yoon, H. S. (2012). The Natively Disordered Loop of Bcl-2 Undergoes Phosphorylation-Dependent Conformational Change and Interacts with Pin1.. PLoS ONE, 7(12), e52047.
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