Nanyang Technology University

Academic Profile
Assoc Prof Philip Wai Hong Chan

Associate Professor 
Division of Chemistry & Biological Chemistry 
School of Physical & Mathematical Sciences 
College of Science 



Email: WAIHONG@ntu.edu.sg
Phone: (+65)63168760 
Office: SPMS-CBC-04-17 
Education
  • DPhil University of Oxford 2003
  • BSc(Hons) University of Bristol 1995
Biography
Educational and Professional Qualifications

1995-1998 D.Phil. (Organic Chemistry), Merton College, University of Oxford, U.K.
1991-1995 B.Sc. Hons. (Chemistry), University of Bristol, U.K.

Professional Experience

2006-present Assistant Professor, Nanyang Technological University, Singapore
2002-2005 Postdoctoral Research Fellow, The University of Hong Kong, Hong Kong, P. R. China
2001-2001 ARC Postdoctoral Research Fellow, University of Sydney, Australia
1999-2000 JSPS Postdoctoral Research Fellow, Tohoku University, Japan
Research Interests
Works in our laboratory are focused on developing new and elegant asymmetric catalytic systems that are of broad utility to synthetic organic chemistry. We are interested in the application of these novel methodologies to the construction of bioactive natural products and as practical synthetic tools for drug discovery, Medicinal Chemistry and Materials Science. Current research themes studied in our group have focused on the development of new synthetic tools for highly efficient and practical functional group transformations in a stereoselective manner. This field of research is of immense importance due to its potential applications in natural product synthesis and drug discovery. We are currently developing novel catalytic methodologies for such bond formation strategies.
Research Grant
  • A*STAR Science and Engineering Research Council - Polish Ministry of Science and Higher Education (MSHE) (2012-)
  • A*STAR Science and Engineering Research Council - Public Sector Funding (2009-)
  • Academic Research Fund Tier 1 (2006-) [by MOE]
  • Start Up Grant (-)
  • Supplementary Equipment Purchase (2006-) [by MOE]
Current Projects
  • Asymmetric Carbon-Nitrogen Bond Formation Reactions: Chiral Transition Metal Catalyzed Stereoselective Carbenoid Transfer Reactions
  • Development of New and Highly Efficient Synthetic Strategies to Carbocycles and Nitrogen-Containing Heterocycles
  • Green and Sustainable Catalysts for Chemical, Agrochemical and Pharmaceutical Industry
  • Ruthenium-Catalyzed Carbon-Nitrogen Bond Formations and Applications to Drug Discovery and Natural Products Synthesis
Selected Publications
  • Kothandaraman, P.; Koh, B. Q.; Limpanuparb, T.; Hirao, H.; Chan, P. W. H. (2013). 1-(2'-Anilinyl)prop-2-yn-1-ol Rearrangement for Oxindole Synthesis. Chemistry - A European Journal, 19(6), 1978-1985.
  • Sze, E. M. L.; Koh, M. J.; Tjia, Y. M.; Rao, W.; Chan, P. W. H. (2013). Synthesis of (Z)-1,2-Dihydro-1-tosylbenzo[b]azepin-3-ones by Two-step, One-Pot Gold-Catalyzed Tandem Heterocyclization/Petasis-Ferrier Rearrangement of 2-(N-(Prop-2-ynyl)-N-tosylamino)benzaldehydes. Tetrahedron, .
  • Rao, W.; Sally; Koh, M. J.; Chan, P. W. H. (2013). Gold-Catalyzed Cycloisomerization of 1,7-Enyne Esters to Structurally Diverse cis-1,2,3,6-Tetrahydropyridin-4-yl Ketones. Journal of Organic Chemistry, 78(7), 3183-3195.
  • Rao, W.; Koh, M. J.; Li, D.; Hirao, H.; Chan, P. W. H. (2013). Gold-Catalyzed Cycloisomerization of 1,6-Diyne Carbonates and Esters to 2,4a-Dihydro-1H-fluorenes. Journal of the American Chemical Society, .
  • Rao, W.; Koh, M. J.; Kothandaraman, P.; Chan, P. W. H. (2012). Gold-Catalyzed Cycloisomerization of 1,7-Diyne Benzoates to Indeno[1,2-c]azepines and Azabicyclo[4.2.0]octa-1(8),5-dines. Journal of the American Chemical Society, 134(26), 10811-10814.
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