Nanyang Technology University

Academic Profile
Asst Prof Kai Tang 

Assistant Professor 
Division of Structural Biology & Biochemistry 
School of Biological Sciences 
College of Science 



Email: TKAI@ntu.edu.sg
Phone: (+65)63167933 
Office: SBS-03s-81 
Education
  • PhD Vanderbilt University 1994
  • BS Fudan University 1986
Biography
Dr. Kai Tang is currently Assistant Professor in the Division of Chemical Biology and Biotechnology, School of Biological Sciences. He received his Bachelor's Degree from Fudan University in China and Ph.D. from Vanderbilt University in USA, respectively. He has worked for 10 years in the biotech industry in the U.S. before joining NTU in 2005. His expertise is in biological mass spectrometry and has more than 40 peer reviewed publications in this area.
Research Interests
Dr. Kai Tang's area of expertise is biological applications of mass spectrometry. His current research works focus on protein experssion profiling, biomarker discovery and clinical diagnostics of thalassemia diseases, one of the most common genetic diseases in Southeast Asia and around the world. He is also working on developing novel methods for pathogen identification and protein structure elucidation.
Research Grant
  • A*Exploit Technologies - Commercialisation of Technology Fund (2011-)
  • Academic Research Fund Tier 1 (2013-)
  • National Medical Research Council (2010-)
Current Projects
  • Characterization of conformational dynamics of RIG-I upon recognition of viral RNA using hydrogen/deuterium exchange coupled with mass spectrometry
  • Direct Mass Spectrometry Analysis of Drug Concentration in Biomatrices with Automated Sampling and Preparation Devices
  • Disease Screening Using Mass Spectrometric Analysis Of Proteolysed Peptide Biomarkers
  • Proteomic analysis of beta-thalassemia : toward correlation and understanding of disease severity
  • Survelliance of More Virulent and Drug-Resistant Influenza A Strands in Singapore by High-Throughput Mass Spectrometry
Selected Publications
  • Rao, F., Chong, H. S., Qi, Y., Kotaka, M., Li, B., Lescar, J., Tang, K., and Liang, Z.-X. (2009). Comparison of RocR and its Constitutively Active Mutant Reveals the Regulatory Mechanism of EAL Domain-Containing Response Regulators. Journal of Bacteriology, 191, 4722-4731.
  • Rajaseger, G., Lim, C. L., Wui, L. K., Saravanan, P., Tang, K., Gopalakrishnakone, P., Yap, E. P., Lu, J and Shabbir, M. M. (2009). A Study on the Differential Protein Profiles in Liver Cells of Heat Stress Rats with and without Turpentine Treatment. BMC Proteome Science, 7, 1-8.
  • Rong Kong, Lan Pei Goh, Chong Wai Liew, Qin Shi Ho, Elavazhagan Murugan, Bin Li, Kai Tang, Zhao-Xun Liang. (2008). Characterization of a Carbonyl-conjugated Polyene Precursor in 10-membered Enediyne Biosynthesis. Journal of the American Chemical Society, 130(26), 8142-8143.
  • Kai Tang. (2007). Chip-Based Genotyping by Mass SpectrometryIntegrated Biochips for DNA Analysis. United States: Landes Bioscience.
  • Yoon, H. R., Kang, C. B., Chia, J., Tang, K. and Yoon, H. S. (2007). Expression, Purification and Molecular Characterization of Plasmodium Falciparum FK506-binding Protein 35 (PfFKBP35). Protein expression and purification, 53, 179-185.
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