- Comparative studies of the structure and adhesion properties of the aLB2, aMb2, aXb2 integrin, and the crystallographic studies of the b2 and b3 integrin
- Dissecting the molecular basis of integrin-tetraspanin complex in immune cells
- Functional coupling of the intracellular proteins talin and kindlin in integrin activation
- Investigating integrin Mac-1-signaling in monocytes
- Investigating kindlin3-mediated signaling in endothelial cells
- Investigating the functions of the FERM-containing cytoplasmic protein kindlin-3 in integrin activation and signalling
- Leukocyte Integrin Alpha Cytoplasmic Tails: Diversity and Functional Specialization
- The protein chemistry of integrin adhesion molecules
- The role integrin activation states in T lymphocyte adhesion and migration
| Selected Publications | - 3. Setyawati, M.I., Tay, C.Y., Chia, S.L., Fang, W., Neo, M.J., Chong, H.C., Tan, S.M., Loo, S.C., Ng, K.W., Xie, J.P., Ong, C.N., Tan, N.S. and Leong, D.T. (2013). Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE-cadherin.. Nature Communications, 4, 1673.
- Tan, S.M. (2012). The leucocyte ß2 (CD18) integrins: the structure, functional regulation and signalling properties. Bioscience Report, 32, 241-269.
- Feng, C., Li, Y.F., Yau, Y.H., Lee, H.S., Tang, X.Y., Xue, Z.H., Zhou, Y.C., Lim, W.M., Cornvik, T.C., Ruedl, C., Shochat, S.G., and Tan, S.M. (2012). Kindlin-3 mediates integrin αLß2 outside-in signaling and it interacts with the scaffold protein receptor for activated-C kinase 1 (RACK1).. J Biol Chem, .
- Chua, G.L., Tang, X.Y., Amalraj, M., Tan, S.M., and Bhattacharjya, S. (2011). Structures and interaction analyses of integrin αMß2 cytoplasmic tails. J Biol Chem, 51, 43842-43854.
- Huang, R-L, Teo, Z.Q., Chong, H.C., Zhu, P.C., Tan, M.J., Tan, C.K., Lam, C.R.I., Sng, M.K., Leong D.W.T., Tan, S.M., Kersten, S., Ding, J.L., Li, H.Y. and Tan, N.S. (2011). ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters. Blood, 118, 3990-4002.
|
|