|SZE Siu-kwan Newman received multidisciplinary research trainings in chemical physics, protein chemistry, protein separation and characterization, and proteomics from University of Hong Kong, University of Toronto, University of Waterloo, and Cornell University under prominent research mentors (Nobel Laureate Professor John Polanyi - Chemical Physics, Professor Janus Pawlizyn - Protein Science, and Professor Fred McLafferty - Mass Spectrometry). After the intensive trainings, he engaged in the R&D of emerging proteomics technology in the Genome Institute of Singapore. After he joined NTU in June 2006, he has embarked on the establishment of a state-of-the-art proteomics facility in School of Biological Sciences and the application of advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines.|
|Our research is devoted to develop and apply advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines. As proteomics is still in the infancy stage, technology development is the key to advance the field to address more sophisticated biomedical questions. During the past few years, we have successfully developed a few novel proteomic techniques and applied to study proteins that are important to transcriptional and translational regulatory networks, DNA repair, and apoptotic pathway. More importantly, we have established a biological and biomarker discovery pipeline to study clinically important proteome systems relevant to host-pathogen response, cancer, and cardiovascular diseases|
- Dissecting the Roles of Scaffolding Proteins in Ras Signaling Pathways
- Enabling phosphorproteome analysis with mass spectrometry in elucidating signalling pathways in cancer and immunity
- Identification of human plaque protein signatures predictive for secondary cardiovascular events using quantitative proteomics
- In vivo structure-based studies on epidermal growth factor receptor (EGFR) signaling in cancer
- Proteomics investigation on the molecular mechanism of hypoxia induced cancer metastasis
- Signaling during Plasmodium falciparum merozoite invasion
- Signatures of human plaque protein levels predictive for human cardiovascular events/Quantitative proteomics on human plaque protein extracts
- Validating candidate biomarkers in plasma microvesicles for the diagnosis and prognosis of lacunar infarction
- P. Hao, T. Guo and S. K. Sze. (2011). Simultaneous analysis of proteome, phospho- and glycoproteome of rat kidney tissue with electrostatic repulsion hydrophilic interaction chromatography. PLoS ONE, 6(2), e16884.
- T. Guo, Y. Zhu, C. S. Gan, S. S. Lee, J. Zhu, H. Wang, X. Li, J. Christensen, S. Huang, O. L. Kon and S. K. Sze. (2010). Quantitative Proteomics Discloses MET Expression in Mitochondria as a Direct Target of MET Kinase Inhibitor in Cancer Cells. Molecular and Cellular Proteomics, 9(12), 2629-41.
- W. Peeters, D. P. de Kleijn, A. Vink, S. van de Weg, A. H. Schoneveld, S. K. Sze, P. J. van der Spek, J. P. de Vries, F. L. Moll and G. Pasterkamp. (2010). Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events. eur heart j, .
- T. Guo, S. S. Lee, W. H. Ng, Y. Zhu, C. S. Gan, J. Zhu, H. Wang, S. Huang, S. K. Sze and O. L. Kon. (2010). Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. cell mol life sci, .
- Adav SS, Li AA, Manavalan A, Punt P, Sze SK. (2010). Quantitative iTRAQ secretome analysis of Aspergillus niger reveals novel hydrolytic enzymes. J Proteome Res, 9(8), 3932-40.