| Assoc Prof Ruedl Christiane
Associate Professor
Division of Molecular Genetics & Cell Biology
School of Biological Sciences
College of Science
Email: RUEDL@ntu.edu.sg
Phone: (+65)65141044
Office: SBS-04n-22 |
| Education |
- PhD University of Innsbruck 1991
- MS(Natural Sci) University of Innsbruck 1988
|
| Biography |
| Assoc Prof Christiane Ruedl is currently in the School of Biological Sciences since 2006. She received her Master and Ph.D. degrees from the Leopold-Franzens University Innsbruck, Austria. Her research interests include immunology and haematopoietic stem cell research. She has done significant research work his research areas and published over 30 top quality international conference and journal papers. Dr. Christiane Ruedl is a member and Assistant Secretary of Singaporean SOciety for Immunology. |
| Research Interests |
My major research interest has been and continues to be how innate and adaptive immunity is regulated. In particular, dendritic cells (DCs)- the major professional antigen presenting cells of the immune system-, have been in my focus for the last few years.
As key players of immune responses, DCs are fine-tuning the balance between the opposing forces of tolerance and immunity, making them attractive candidates for several clinical applications. We are currently engineering ?tailor-made? DCs by overexpressing or deleting genes known to be involved in DC-mediated tolerance with the aim of a therapeutic application in a variety of disease, like autoimmunity, transplantation or gene therapy. |
| Research Grant |
- Academic Research Fund Tier 1 (2009-)
- Academic Research Fund Tier 1 (2011-)
- Academic Research Fund Tier 1 (2012-)
- Academic Research Fund Tier 2 (2012-)
- National Medical Research Council (2010-)
- National Medical Research Council (2011-)
- National Medical Research Council (2012-)
|
| Current Projects |
- Characterization of different monoclonal antibodies generated against dengue non-structural protein 1 (NS1)
- Enhancing tolerogenic potential of dendritic cells for therapeutic goal
- Enhancing tolerogenic potential of dendritic cells for therapeutic goals
- Genetically engineered 1L-2 deficient dendritic cells will be used to reveal the contribution of 1l-2 produced by dendritic cells in first steps of immune response
- Identification of roles of different myeloid cells in influenza immunity and pathology
- Importance of distinct myeloid cell subsets in protection and pathology to malaria parasite
- New insights for better vaccines: Understanding the role of growth factor GM-CSF in inflammasome activation
- Novel T cell-derived factor induces robust dendritic cell maturation-search for new adjuvants
- Novel t-cell derived factor induces robust dendritic cell maturation-search for new adjuvant
- Role of tight junction proteins in adaptive and innate immunity
- Roles of dendritic cell subsets in Candida infection
- Roles of macrophage and dendritic cell lineages in immunity against Mycobacterium tuberculosis
| Selected Publications | - Ruedl C. Schwarz K. (2005). VLPs as carriers for T cell epitopes: limited inhibition of T cell priming by carrier-specific antibodies. J. Virol, 79(2), 717-24.
- Marsland BJ, Battig P, Bauer M, Ruedl C, Lassing U. (2005). CCL19 and CCL21 induce potent proinflammatory differentiation program in licensed dendritic cells. Immunity, 22(4), 493-505.
- Sirena D. , Lilienfeld , Ruedl C. (2004). The human membrane cofactor CD46 is a receptor for the species B Adenovirus serotype 3. J. Virol, 78 (9), 4454-62.
- Storni, T., C. Ruedl. (2004). Nonmethylated CG Motifs Packaged into Virus-Like Particles Induce Protective Cytotoxic T Cell Responses in the Absence of Systemic Side Effects. J Immunology, 172(3), 1777-85.
- Ruedl C, Bauer M,. (2004). Rapid functional cloning of cell adhesion molecules. Biotechniques, 37(6), 912-16.
|
|