| Assoc Prof Phan Anh Tuan
Head, Division of Physics & Applied Physics
Division of Physics & Applied Physics
School of Physical & Mathematical Sciences
College of Science
Email: PHANTUAN@ntu.edu.sg
Phone: (+65)65141915
Office: SPMS-PAP-05-04 |
| Education |
- PhD Ecole Polytechnique 1999
- MS(Biophysics) University of Paris XI 1996
- Diploma(Phys)(Hons) M.V.Lomonosov Moscow State University 1995
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| Biography |
| Dr. Phan is a faculty member in the School of Physical and Mathematical Sciences since October 2006. He received his Bachelor and Master degrees in Physics and Mathematics from the Lomonosov Moscow State University, Russia, Master in Biophysics from the University of Paris XI, France, and Ph.D. in Biophysics from the Ecole Polytechnique, France. Dr. Phan worked as a Research Scientist at the Memorial Sloan-Kettering Cancer Center, New York, USA, for five years before taking up the current appointment at NTU. His research interests include Biophysics and Structure of Nucleic Acids. He publishes regularly in prestigious international journals. Several of his publications have received highlights and reviews in most prestigious journals, including Cell and Nature. |
| Research Interests |
Dr. Phan's research focuses on the use of a combination of physical, chemical and computational methods to investigate and manipulate properties of biomolecules. The research goals include:
(1) Structures, dynamics, interactions and functions of DNA, RNA and proteins.
(2) Noncanonical structures of DNA and RNA as molecular targets against diseases.
(3) Structural design and engineering of nucleic acids and proteins.
(4) Application and development of methods, including Nuclear Magnetic Resonance (NMR) and other spectroscopic techniques, as well as single-molecule manipulations, for the study of biomolecular structures and dynamics. |
| Research Grant |
- A*STAR Biomedical Research Council (2008-) [by A*STAR Biomedical Research Council (BMRC)]
- Academic Research Fund Tier 1 (2008-)
- Academic Research Fund Tier 1 (2011-)
- MERLION (2012-)
- SPMS Collaborative Research Award (2011-)
- Start Up Grant (-)
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| Current Projects |
- Biophysical Study of DNA and DNA-Ligand Complexes
- G-Quadruplex-Induced Genome Instability
- Guanine-rich DNA Oligomers: Structure and Activity Against HIV and Cancer
- Potential DNA Quadruplexes In Human Minisatellites
- Solid State Nanopore Devices for Single Molecule Biophysics and Sequencing
- Structural Analysis of HMGA-DNA Complexes at Abasic Sites
| Selected Publications | - Yue DJ, Lim KW, Phan AT. (2011). Formation of (3+1) G-Quadruplexes with a Long Loop by Human Telomeric DNA Spanning Five or More Repeats. Journal of the American Chemical Society, 133(30), 11462-11465.
- Mukundan VT, Do NQ, Phan AT. (2011). HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges. Nucleic Acids Research, 39(20), 8984-8991.
- Do NQ, Lim KW, Teo MH, Heddi B, Phan AT. (2011). Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity. Nucleic Acids Research, 39(21), 9448-9457.
- Martadinata H, Heddi B, Lim KW, Phan AT. (2011). Structure of Long Human Telomeric RNA (TERRA): G-Quadruplexes Formed by Four and Eight UUAGGG Repeats Are Stable Building Blocks. Biochemistry, 50(29), 6455-6461.
- Heddi B, Phan AT. (2011). Structure of human telomeric DNA in crowded solution. Journal of the American Chemical Society, 133(25), 9824-9833.
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