Nanyang Technology University

Academic Profile
Asst Prof Tan Nguan Soon 

Assistant Professor 
Division of Molecular Genetics & Cell Biology 
School of Biological Sciences 
College of Science 



Email: NSTAN@ntu.edu.sg
Phone: (+65)63162941 
Office: SBS-02s-60 
Education
  • PhD National University of Singapore 1997
  • BSc(Hons) (Cell & Molecular Bio) National University of Singapore 1993
  • BSc National University of Singapore 1992
Biography
2005-present Assistant Professor, College of Sciences, School of Biological Sciences, NTU
2006-2008 Assistant Chair (Undergraduate Affairs)
2000-2004 Research Fellow (Prof Walter Wahli’s lab, Center for Integrative Genomics, Switzerland
1997-1999 Postdoc. (Prof Ding Jeak Ling’s lab), National University of Singapore, Singapore

2007 Nanyang Award 2007- Excellence in Teaching
2002-2003 A*STAR International Fellowship
Research Interests
My research centered on peroxisome proliferators-activated receptors (PPARs) signaling in several complex processes which are of extreme clinical relevance.
Wound repair
Effective wound repair requires the interactions among immune cells, keratinocytes, fibroblasts and endothelial cells. Mesenchymal-epidermal interactions play a crucial role in skin homeostasis and tissue repair. My laboratory research concerns the crosstalk of signaling pathways invoked during barrier and skin repair, especially in obese and/or diabetic conditions.
Carcinogenesis
Many evidences clearly support a tumor-promoting role of inflammation in the development and progression of epithelial skin cancer. Tumor-promoting microenvironment resembling the wound environment is indispensable for tumor formation and progression. PPARs play important role in carcinogenesis. My laboratory is interested in the impact of tumor microevironment on the PPAR activity.
Research Grant
  • A*STAR Biomedical Research Council (2011-)
  • A*STAR Biomedical Research Council - Singapore Stem Cell Consortium (2010-)
  • Academic Research Fund Tier 1 (2013-)
  • Academic Research Fund Tier 2 (2008-)
  • Academic Research Fund Tier 2 (2011-)
  • College of Science Collaborative Research Award (2011-)
  • NTU-NHG Innovation Seed Grant (2011-)
  • National Medical Research Council (2011-)
  • Singapore Cancer Society (2012-2013)
Current Projects
  • A feasibility study of keratin as a tissue regeneration template for chronic wounds (Proj Code: ISG/11021)
  • A study to investigate the mechanism by which angiopoietin-like 4 modulates superoxide level in tumour for anoikis resistance- an anticancer therapeutic focused on the induction of redox-based apoptosis in tumors
  • Cancer-Associated Fibroblasts-Specific Nuclear Receptor Prognostic Signature
  • Effect of topical application of encapsulated PPARbeta/delta agonist GW501516 microparticles, with two release kinetics, on cutaneous wound healing in diabetic mice – a preclinical animal study
  • Establishment of a 3D biologically relevant cancer cell niche for high-throughput cancer drug screening
  • Modulating mesenchymal stem cell differentiation by controlling cellular morphology and material surface topography
  • Role of tumor-derived angiopoetin-like protein 4 in cancer metastasis
  • Somatic missense mutations of ANGPTL4 and its biological consequence on oncogenic ROS production and metastasis
  • The role angiopoitin-like 4 (ANGPTL4) in angiogenesis during wound healing and cancer growth
Selected Publications
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