| Assoc Prof Chan Vincent
Associate Chair (Academic), School of Chemical and Biomedical Engineering
Division of Chemical and Biomolecular Engineering
School of Chemical and Biomedical Engineering
College of Engineering
Email: MVCHAN@ntu.edu.sg
Phone: (+65)6790 6739
Office: N1.2-B2-26/01-13 |
| Education |
- PhD University of Pennsylvania 1997
- BChE University of Minnesota 1993
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| Biography |
| I am from Hong Kong. I graduated with B.ChE. from University of Minnesota in 1993. Eventually, I pursued my Ph.D. in Chemical Engineering at University of Pennsylvania and graduated in 1997. I spent two years in biotechnology industry in USA before joining NTU in 1999. Currently, I am an associate professor in the School of Chemical and Biomedical Engineering. |
| Research Interests |
Understanding the biophysical properties of cells on biomaterials is essential for designing new tissue regeneration processes and for developing new biomedical devices. Our main objective is to reveal the synergistic interplay between biochemical, physical and mechanical signals in the regulation of cell adhesion, regenerations and recovery on biomaterials or extracellular matrix (ECM).
Integrative bio-analytics are critical to our research. Using functional microscopy, optical tweezers and atomic force microscopy, we examine the biophysical dynamics of cell regeneration, biomechanics of membrane and dynamic adhesion of bacteria. We will devise important design principles for engineered tissue equivalents, bio-inspirational materials and anti-microbial devices. I have been working in the following research topics during the last 9 years at Nanyang Technological University:
i) Biophysical Dynamics of Cell Regenerations
ii) Biophysical Mechanics of Membrane
iii) Development of Integrative Biophysical Instrumentation |
| Research Grant |
- Environment & Water Industry Development Council (2013-) [by Public Utilities Board (PUB)]
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| Current Projects |
- Biophysics of Cell Regeneration on Thermo-sensitive Polymer
- Confluence-released Mechanotransduction of Vascular Smooth Muscle Cells Using Novel Three-Dimensional Micropatterned Scaffold
- Effect of Viral Proteins on Cell Deadhesion Dynamics
- Engineering Cell Deadhesion/Detachment Dynamics on Thermo-responsive Polymer for Tissue Regeneration
- Fouling in Submerged Anaerobic Membrane BioReactors (SAMBRs) - Flux, Cod and Virus Removal
| Selected Publications | - Chen B, Xu FJ, Neoh KG, Kang ET, Chen WN and Chan V. (2008). Engineering cell de-adhesion dynamics on thermo-responsive Poly(N-isopropylacrylamide). Acta Biomaterialia, 4, 218-229.
- B. Chen, J. Dang, T.L.Tan, N. Fang, W.N. Chen, K.W. Leong and V. Chan. (2007). Dynamics of smooth muscle cell de-adhesion from thermosensitive hydroxybutylchitosan. Biomaterials, 28, 1503-1514.
- A.P. Zhu, N. Fang, M.B. Chan-Park and V. Chan. (2006). Adhesion contact dynamics of 3T3 fibroblasts on poly (lactide-co- glycolide acid) surface: regulation modified by chitosan and gelatin surfacephotochemical immobilization of biomacromolecules. Biomaterials, 27(12), 2566-2576.
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