Nanyang Technology University

Academic Profile
Asst Prof Chang Wook, Matthew

Assistant Professor 
Division of Chemical and Biomolecular Engineering 
School of Chemical and Biomedical Engineering 
College of Engineering 



Email: MATTHEWCHANG@ntu.edu.sg
Phone: (+65)6513 8063 
Office: N1.2-B2-33 
Education
  • PhD University of Maryland 2003
  • BS Seoul National University 1998
Biography
Dr. Matthew Chang is an assistant professor of the Division of Chemical and Biomolecular Engineering at Nanyang Technological University (NTU). He received his Ph.D. from the University of Maryland in the United States and his B.S. (Cum Laude) from Seoul National University in Korea. Prior to joining NTU in 2007, he was a research assistant professor at the University of Maryland Biotechnology Institute. Dr. Chang has expertise in systems biology, metabolic engineering, and engineering biology. He is a recipient of the 2007 Scientific and Technological Achievement Award (STAA) from U.S. Environmental Protection Agency.

Research Interests
Prof. Chang's areas of expertise are systems biology, metabolic engineering, and engineering biology. His current research works focus on elucidating genetic regulatory networks and relevant cellular mechanisms in bacteria.
Research Grant
  • A*STAR Biomedical Engineering Programme (BEP) (2011-2013) [by A*STAR Science & Engineering Research Council (SERC)]
  • A*STAR Science and Engineering Institutes (2012-) [by A*STAR Science and Engineering Institutes (SCEI)]
  • NEA Environment Technology Research Programme (2013-) [by National Environmental Agency (NEA)]
  • NRF Competitive Research Program (2010-) [by National Research Foundation (NRF)]
  • National Medical Research Council (2012-) [by National Medical Research Council (NMRC)]
Current Projects
  • Conversion of food waste to 1-butanol using a novel yeast platform
  • Development of Therapeutic Microbes for Prevention and Treatment of Infectious Disease
  • Development of an Infection-resistant Urinary Catheter Coated by Short Antimicrobial Peptides
  • Engineering biology for valuable fuels- Cellular systems engineering for alkane conversion and recovery
  • Engineering biology for valuable fuels- Deconstruction of biomass feedstock
  • Engineering biology for valuable fuels- Engineering of metabolic flux for percursor synthesis
  • Engineering biology for valuable fuels- Integration project
  • Engineering biology for valuable fuels- Intracellular conversion of acyl-CoA to alkanes
  • Engineering oxidative response genetic networks for identifying antimicrobial targets
  • Functional probiotics as next-generation anticancer dietary supplements
  • New Research Initiatives in Chemical and Bioengineering Areas
  • Novel silver nanoparticle/Multi-walled carbon nanotube nanohybrid coating for disinfection and biofouling control in drinking water treatment
  • Technology development for the biological production of dodecanedioic acid from the plant-derived long-chain fatty acid
Selected Publications
  • Lo T, Tan MH, Hwang IY, Chang MW*. (2013). Designing a synthetic genetic circuit that enables cell density-dependent auto-regulatory lysis for macromolecule release. Chemical Engineering Science, .
  • Lo T, Teo WS, Ling H, Chen BB, Kang A, Chang MW*. (2013). Engineering strategies towards robust growth and productivity in microbial cell factories. Biotechnology Advances, .
  • Chen BB, Ling H, Chang MW*. (2013). Transporter engineering for improved tolerance against alkane biofuels in Saccharomyces cerevisiae. Biotechnology for Biofuels, .
  • Kang A, Tan MH, Ling H, Chang MW*. (2013). Systems-level characterization and engineering of oxidative stress tolerance in Escherichia coli under anaerobic condition. Molecular Biosystems, 9, 285-295.
  • Saeidi N., Wong C.K., Lo T-M, Nguyen H.X., Ling H., Leong S.S.J., Poh C.L., Chang M.W. (2012). Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen. Molecular Systems Biology, 7, 521.
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