Academic Profile

Academic Profile

Prof Michael Alan Ferenczi

Professor, Lee Kong Chian School of Medicine

Prof Michael Alan Ferenczi

Prior to joining LKCMedicine in August 2012, Prof Ferenczi was Professor of Physiological Sciences at Imperial College London, a position held since 2001. He retains a Visiting Professorship at Imperial College and an active laboratory. As an enthusiastic teacher in the Faculty of Medicine, he held formal responsibilities for the delivery of undergraduate teaching. Prof Ferenczi was Head of the 'Molecules, Cells and Disease' Theme for students in Years 1 and 2, and since 2007 was Head of Year 4, the year during which medical students take a break from clinical training to undergo a Science year and gain a B.Sc. Degree in a specialty of their choice.

Prof Ferenczi was Head of the Molecular Medicine Section at the National Heart and Lung Institute of Imperial College where 10 Principal Investigators and about 80 scientists explore a variety of biological systems and disease processes using basic science techniques such as molecular biology, animal models and advanced optical microscopies. Within the Molecular Medicine Section, Prof Ferenczi ran the Muscle Biophysics laboratory. His research is now concentrating on the new laboratory of Cardiac Biophysics in LKCMedicine at NTU. A Tier 2 grant from MOE will provide initial funding until 2016. Mike has recruited three new post-doctoral fellows with whom he will be exploring the relationship between phosphorylation of cardiac light chains and cardiac performance. New opportunities for collaboration are developing with other schools and colleges in NTU, for example with Chenjie Xu in Bioengineering (SCBE) to explore fibrosis in skin using Second Harmonic signal Generation.

Prior to Imperial College, Mike worked at the UK Medical Research Council's National Institute for Medical Research (NIMR) in Mill Hill, London (1983-2001). Previously he had spent three years at the University of Pennsylvania, Philadelphia after obtaining his Ph.D. in the Physiology Department at University College London in 1979.

Mike has a lifelong interest in the development of biophysics, bringing quantitative methodologies to biological applications. He is a long-standing member of the British Biophysical Society's Executive Committee (BBS), and of the Executive Committee of the European Biophysical Societies' Association (EBSA).
Research Interests
Prof Ferenczi’s interest is the understanding of the molecular mechanism of movement in biological systems. Since muscle is an organ specialised in the achievement of movement, his focus is on biophysics and biochemistry of muscle fibres using permeabilised muscle fibres from a variety of sources, caged-compounds, fluorescent reporter probes, low angle X-ray diffraction at ESRF, FLIM (Fluorescence Lifetime Imaging Microscopy) and SHG.
Current Projects
  • Bringing information literacy into the classroom: A modelfor librarian - faculty collaboration
  • Physiology & Anatomy of Heart Failure Progression: Role of RLC Phosphorylation
  • Sarcomeric metabolic rate regulation in resting skeletal muscle - a potential way to treat obesity and diabetes
Selected Publications
  • Toepfer C., West T.G., Ferenczi M.A. (2016). Revisiting Frank-Starling: regulatory light chain phosphorylation alters the rate of force redevelopment (ktr) in a length-dependent fashion.. Journal of General Physiology, 1113(10), JP272441.

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