Academic Profile

Academic Profile

Asst Prof Luo Dahai

Nanyang Assistant Professor, Lee Kong Chian School of Medicine

Phone: +65 65923986
Office: EMB 03 01
Asst Prof Luo Dahai

Academic Qualifications:
1. Bachelor of Science (Honours)
Nanyang Technological University (NTU), Singapore 2002 – 2006
2. Doctor of Philosophy
NTU, Singapore 2006 – 2010

Professional Qualification(s)/Membership(s):
1. Young Investigator The European Molecular Biology Organization (EMBO) 11/2017 – 10/2021
2. Member Singapore Center of Excellence of Global Virus Network 2018 – Present

Employment History:
1. Research Internship Novartis Institute for Tropical Diseases, Singapore 06/2006 – 05/2007
2. Project Officer School of Biological Sciences (SBS), NTU, Singapore 09/2007 – 04/2010
3. Postdoctoral Fellow Howard Hughes Medical Institute, Department of Molecular Cellular and Developmental Biology, Yale University, USA 05/2010 – 09/2013
4. Nanyang Assistant Professor LKCMedicine, NTU, Singapore 09/2013 – Present
Research Interests
My primary research interest is to understand the molecular events involved in the battle between host and pathogens, in particular between RNA viruses and humankind. I developed this interest after I started my graduate work and I further cultivated it during my postdoctoral training. Using various methods ranging from biochemistry, biophysics, structural biology, and cell biology, I successfully answered interesting and demanding questions in the fields of viral replication and host defense systems. I would like to further my research career to better understand the conflict between host and pathogens and improve the well-being of humankind. My lab’s research focuses on the following two interrelated directions: 1) RNA virus transcription, replication, and the generation of pathogenic RNA species; 2) Host defense mechanisms involved in pathogenic RNA sensing and processing. We would like to exercise molecular engineering targeting RNA and RNA-protein complexes to develop new methods and tools for research and therapies.
Current Projects
  • Define Molecular Basis of Transcription and Replication of Chikungunya Virus
  • Develop next generation antimicrobial ectolysins
  • Development of immune-modulatory RNAs to regulate RIG-I mediated antiviral immune response for therapy and vaccination
  • Dissecting the flavivirus replication complex for the discovery of antiviral inhibitors
  • Dissecting the flavivirus replication complex for thediscovery of antiviral inhibitors
  • Fighting for Better Survival: Viral RNA Biogenesis versus Host Defense
  • LKCMedicine Internal Grant 24
  • Recreate dengue virus replication in E. coli
  • Start-Up Grant
  • Structural & Functional Studies of Chikungunya virus replication complex
  • Structural and Functional Characterization of Antiviral Protein Variants Generated via Intronic Polyadenylation
  • Structure Determination of NLRP6: Towards defining its unique role in innate immunity, microbiota, and homeostasis of the gut
  • Studying Zika virus pathogenesis and the development of therapeutics, in vitro cell culture model and mouse models that display various disease phenotypes
  • Targeting Dengue Non Structural Protein 3 and its EssentialInteractions With Small Molecules.

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