Academic Profile

Academic Profile

Asst Prof Luo Dahai

Nanyang Assistant Professor (NTU)

College Dean's Office

Lee Kong Chian School of Medicine

Phone: (+65)6592 3986
Office: NTU, EMB Level 3

  • PhD (School of Biological Sciences) Nanyang Technological University 2010
  • BSc (School of Biological Sciences) Nanyang Technological University 2006
  • PhD Nanyang Technological University 2009
  • BSc(Bio.Sc)(Hons) Nanyang Technological University 2006
Current Projects
  • Define Molecular Basis of Transcription and Replication of Chikungunya Virus
  • Develop next generation antimicrobial ectolysins
  • Development of immune-modulatory RNAs to regulate RIG-I mediated antiviral immune response for therapy and vaccination
  • Dissecting the flavivirus replication complex for the discovery of antiviral inhibitors
  • Dissecting the flavivirus replication complex for thediscovery of antiviral inhibitors
  • Fighting for Better Survival: Viral RNA Biogenesis versus Host Defense
  • LKCMedicine Internal Grant 24
  • Recreate dengue virus replication in E. coli
  • Start-Up Grant
  • Structural & Functional Studies of Chikungunya virus replication complex
  • Structural and Functional Characterization of Antiviral Protein Variants Generated via Intronic Polyadenylation
  • Structure Determination of NLRP6: Towards defining its unique role in innate immunity, microbiota, and homeostasis of the gut
  • Studying Zika virus pathogenesis and the development of therapeutics, in vitro cell culture model and mouse models that display various disease phenotypes
  • Targeting Dengue Non Structural Protein 3 and its EssentialInteractions With Small Molecules.
Selected Publications
  • Tay, M. Y. F., Saw, W. G., Zhao, Y., Chan, W. K. K., Singh, D, Chong, Y., Forwood, J. K., Ooi, E. E., Grüber, G., Lescar, J., Luo, D., and Vasudevan, S. G. (2015). The C-terminal 50 amino acid residues of Dengue NS3 protein are important for NS3-NS5 interaction and viral replication. Journal of Biological Chemistry, 290, 2379-2394.
  • Luo, D., Xu, T., Watson, R. P., Scherer-Becker, D., Sampath, A., Jahnke, W., Yeong, S. S., Wang, C. H., Lim, S. P., Strongin, A., Vasudevan, S. G., Lescar, J. (2008). Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO Journal, 27(23), 3209-19.
  • Lescar, J., Luo, D., Xu, T., Sampath, A., Lim, S. P., Canard, B., Vasudevan, S. G. (2008). Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Research, 80(2), 94-101.
  • Luo, D., Xu, T., Hunke, C., Gruber, G., Vasudevan, S. G., Lescar, J. (2008). Crystal structure of the NS3 protease-helicase from dengue virus. Journal of Virology, 82(1), 173-83.
  • Xu T., Sampath A, Chao A, Wen D, Nanao M, Chene P, Vasudevan S G & Lescar J. (2006). Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain. Novartis Found Symp, 277, 86-100.

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