Academic Profile
Prof Lars Nordenskiold 
Associate Dean (Academic), College of Science
 
Division of Structural Biology & Biochemistry 
School of Biological Sciences 
College of Science 



Email: LARSNOR@ntu.edu.sg
Phone: (+65)65927506 
Office: SBS-01s-45 
Education
  • PhD Stockholm University 1981
  • BSc Stockholm University 1976
Biography
Professional Experience
• Post doctoral stay at University of Wisconsin-Madison, USA, 1982-1983.
• Faculty appointment at Stockholm University, Division of physical chemistry, 1983-2002.
• Full professor in physical chemistry at Stockholm University, from 2000.
• Professor at School of Biological sciences, NTU, Singapore from 2002.
Research Interests
• Chromatin Biophysics: Electrostatic and Molecular Mechanisms of Chromatin Condensation
• DNA Compaction and Gene Delivery
Research Grant
  • A*STAR Biomedical Research Council (2011-2014)
  • Academic Research Fund Tier 1 (2014-)
  • Academic Research Fund Tier 3 (2013-)
Current Projects
  • Biophysical Studies of Nucleosome Arrays with Site-Specifically Modified Histone Tails
  • Characterization and understanding of DNA compaction and DNA-peptide/ligand interactions with applications to gene regulation and delivery:Biophysics and computer modelling approaches
  • Developing multi-scale computer simulation models for a complete coarse-grained description of biopolymer assemblies including solvent effects
  • General Biophysics Research
  • Investigation of DNA Photolyase Repair Dynamics in Chromatin Using Ultrafast Spectroscopy
  • Multi-Scale Simulations of Biomolecular Self-Assembly by Inverse Monte Carlo
  • Self-Assembly and ordered structure of phospholipid complexes with nucleosome and chromatin
  • Structural response of chromatin to epigenetic modifications by solid state NMR
  • Synthesis, Biophysical Characterization and Delivery properties of novel peptides for integrin targeting in non viral gene delivery to cancer cells
  • Telomere Dynamics and Genome Function: From DNA to Nucleosomes to Chromosomes
Selected Publications
  • Y. Yang, A. P. Lyubartsev, N. Korolev, L. Nordenskiold. (2009). Computer modeling reveals that modifications of the histone tail charges define salt-dependent interaction of the nucleosome core particles. Biophysical Journal, 96, 2082-2094.
  • L. Dai, YG. Mu, L. Nordenskiold, A. Lapp, and Johan R. C. van der Maarel,. (2007). Charge Structure and Counterion Distribution in Hexagonal DNA Liquid Crystal. Biophysical Journal, 92(3), 947-958.
  • Dandan Huang, Nikolay Korolev, James P. Tam, Khee Dong Eom, Lars Nordenskiold. (2007). Design and biophysical characterization of novel polycationic e-peptides for DNA compaction and delivery. Biomacromolecules, .
  • Nikolay Korolev, Olga V. Vorontsova, Lars Nordenskiold. (2007). Physicochemical analysis of electrostatic foundation for DNA-protein interactions in chromatin transformations. Progress in Biophysics & Molecular Biology, 95(1-3), 23-49.
  • Nikolay Korolev, Lars Nordenskiold. (2007). H4 histone tail mediated DNA-DNA interaction and effects on DNA structure, flexibility, and counterion binding: a molecular dynamics study. Biopolymers, 86(5-6), 409-423.
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