|Asst Prof Kunn Hadinoto Ong|
Division of Chemical and Biomolecular Engineering
School of Chemical and Biomedical Engineering
College of Engineering
Phone: (+65)6514 8381
- PhD Purdue University 2004
- BSc University of Washington 2000
|Assistant Professor Kunn Hadinoto Ong joined the School of Chemical and Biomedical Engineering in 2007. He received his bachelor degree in chemical engineering from the University of Washington (Seattle, USA) in 2000 and his doctoral degree also in chemical engineering in 2004 from Purdue University (West Lafayette, USA). His research interests are in the area of particle technology with an emphasis on computational fluid dynamics (CFD) of turbulent multiphase flows and particle engineering for pharmaceutical applications. |
1) Computational fluid dynamics (CFD) modeling of turbulent particle-laden flow (i.e. gas-particle and liquid-particle flows) that are widely employed in the petroleum and pharmaceutical industries. For example, fluid catalytic cracking (FCC)reactor, coal gasification, pharmaceutical batch crystallizer, powder mixer, and fluidized bed granulator. The two-phase flow CFD model is crucial in the design, scale-up, and optimization of these processes.
2) Experimental investigation of the particle-laden flow phenomena using advanced optical technique such as Particle Image Velocimetry (PIV)and Laser Doppler Velocimetry (LDV). Using these techniques, multiple flow variables are measured simultaneouly to validate the CFD model predictions and also to gain an improved understanding on the intricate particle-laden flow phenomena
3) Engineered aerosol carrier particles to deliver nanoparticulate drugs by inhalation. A novel formulation technique by means of spray-drying is develop to manufacture micron-scale carrier particles of nanoparticulate drug for inhaled drug delivery using a dry powder inhaler (DPI)
|Research Grant |
- Academic Research Fund Tier 1 (2011-) [by Nanyang Technological University]
- GSK-Singapore Partnership (2012-)
|Current Projects |
- Co-Formulations of Inhalable Antibiotic Nanoparticles and Mucolytic Agents for Lung Biofilm Infection Therapy
- Inhalable Biofilm-Targeting Lipid-Conjugated Antibiotic Nanoparticles for Chronic Lung Infection Therapy against P. aeruginosa
- New Research Initiatives in Chemical and Bioengineering Areas
- Process Intensification of Nanocrystalline API Production and Micro-Granulation towards Sustainability
- Taste Masking of Eurycoma longifolia Extracts by Encapsulation
- T. Chen, K. Hadinoto, W. Yan, Y. Ma. (2011). Efficient meta modeling of complex process simulation with time-space-dependent outputs. Computers and Chemical Engineering, 35(3), 502-509.
- S.P. Goy, J.W. Chew, K. Hadinoto. (2011). Effects of binary particle size distribution on minimum pick-up velocity in pneumatic conveying. Powder Technology, 208, 166-174.
- K. Kho, K. Hadinoto. (2011). Optimizing aerosolization efficiency of dry-powder aggregates of thermally sensitive polymeric nanoparticles produced by spray freeze drying. Powder Technology, 214, 169-176.
- W.S. Cheow, M.W. Chang, K. Hadinoto. (2011). The role of lipid in anti-biofilm efficacy of lipid-polymer hybrid nanoparticles encapsulating antibiotics. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 389, 158-165.
- W.S. Cheow, K. Hadinoto. (2011). Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles. Colloids and Surfaces B: Biointerfaces, 85, 214-220.