|Prof. Luo's areas of expertise include genetic and protein engineering, design and application of fluorescent-based biosensor in living cell analysis, apoptosis, cancer cell metastasis, microfluidics systems and nanomization using supercritical CO2 method.
Her current research works focus on four areas:
1. Drug discovery: Using a biosensor-based high throughput assay to discover novel anti-cancer drugs from Chinese herbal medicines and study the mechanisms of drug action.
2. Cancer Research: Applying the FRET-based caspase sensor to study apoptosis, metastasis and angiogenesis in co-culture system, zebrafish and nude mice models.
3. Nanomedicine and pharmaceutical engineering: Using nanotechnology to enhance the solubility and bioavailability of drug candidates and determine their pharmacokinetic profiles using the Caco-2 cell monolayer model and in animals.
4. Microfluidic research: Using MEMS technology to study the mechanisms of endothelial cell dysfunction in the vascular complications of diabetes in microfluidic systems.
- A pilot study evaluating caspase-3 activation as a novel marker of systemic toxicity in breast cancer patients receiving chemotherapy
- Discovering new anticancer drug candidates from Chinese medicinal herbs by a novel FRET-based high-throughput apoptosis assay
- Evaluating the growth inhibition effect of a new anticancer agent in animal with xenografted tumor derived from breast cancer patients
- No title (Start-up Grant - Kathy Luo)
- Optofluidic system for bacterial detection and identification
- Pharmacokinetic and toxicity studies of a new anti-breast cancer agent (ATA) in animal models
- Pharmacologic Fingerprints of Selected Herbal Products
- Yu JQ, Liu XF, Chin LK, Liu AQ, Luo KQ*. (2013). Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system. Lab on a Chip, , DOI:10.1039/C3L.
- Lin CS, Xu J, Ng KM, Wibowo C, Luo KQ. (2013). Encapsulation of a low aqueous solubility substance in a biodegradable polymer using supercritical fluid extraction of emulsion. Industrial & Engineering Chemistry Research, 52(1), 134-141.
- Feng C, Zhou LY, Yu T, Xu G, Tian HL, Xu JJ, Xu HX, Luo KQ*. (2012). A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through Bax activation. International Journal of Cancer, 131(6), 1445-1454.
- Wu ZM, Ling L, Zhou LY, Guo XD, Jiang W, Qian Y, Luo KQ, Zhang LJ. (2012). Novel preparation of PLGA/HP55 nanoparticles for oral insulin delivery. Nanoscale Research Letters, 7, Article: 299.
- Wu ZM, Zhou L, Guo XD, Jiang W, Ling L, Qian Y, Luo KQ, Zhang LJ. (2012). HP55-coated capsule containing PLGA/RS nanoparticles for oral delivery of insulin. International Journal of Pharmaceutics, 425(1-2), 1-8.