Academic Profile

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Academic Profile

Prof Klaus Erik Karjalainen


Professor

School of Biological Sciences
College of Science

Email: KLAUS@NTU.EDU.SG
Phone: (+65)65141033
Office: SBS-04n-23

Education
  • PhD Helsinki University 1979
  • MD Helsinki University 1976
Biography
Prof Klaus Karjalainen is currently in the School of Biological Sciences since 2006. He received his MD and PhD. degrees from the Helsinki University, Finland. After the four year postdoctoral studies in USA he joined the Basel Institute for Immunology for 18 years up to its closure. His interests include immunology and haematopoietic stem cell research. He has done significant research work in his research areas and published over 70 top quality international journal papers.
Research Interests
All the cells of the blood and immune system are derived ultimately from hematopoietic stem cells (HSC). Therefore, understanding of the rules that govern the maintenance and turn over of HSC is the key to the whole hematopoietic system and especially important to the further improvement of the efficiency of bone marrow (BM) and cord blood transplantations in clinics.

Using in vitro culture systems and genetically modified BM and stromal cells we attempt to build a niche that can support HSC self-renewal and hence provide us unlimited source of HSC for therapeutical purposes.

T lymphocytes are the main players in adaptive immunity and the deficiency in their production or function can lead e.g. to dramatic immunodeficiences as exemplified by AIDS and to increasingly more prevalent immune dysfunctions associated in aging.

Since T lymphocytes are generated in thymus we have started to characterize novel genes that are induced and expressed in developing thymocytes. We will use cell biological, genetical, and biochemical approaches in order to understand their roles in T cell development.
Current Projects
  • A model for human experimental immunology
  • Discovery & characterization of local stem cells that regenerate brain microglia
  • Functional roles of miR-125 family members in hematopoiesis
  • Improved murine host for human tissues and primary tumors
  • Molecular cues guiding T cell development
  • Molecular cues guiding the self-renewal of hematopoietic stem cell
  • New discovery tools for human myelodysplastic syndromes
  • Role of obesity drive low-grade inflammation in diabetes and cardiovascular diseases-new discovery tool for obesity research
  • Roles of macrophage and dendritic cell lineages in immunity against Mycobacterium tuberculosis
  • Self renewal of hematopoietic stem cells
  • The Transgenesis Costs at A*STAR
Selected Publications
  • Schwartzkopf S, Grundemann C, Schweier O, Rossart S, Karjalainen KE, Becker KF, Pircher H. (2007). Tumor-associated E-cadherin mutations affect binding to the killer cell lectin-like receptor G1 in humans. Journal of Immunology, 179(2), 1022-9.
  • Kisielow M., Kisielow J., Capoferri-Sollami g., Karjalainen K. (2005). Expression of lymphocyte activation gene 3 (LAG-3) on B cells is induced by T cells. European Journal of Immunology, 35(7), 2081-8.

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