Academic Profile

Academic Profile

Assoc Prof Julien Lescar

Associate Professor, School of Biological Sciences

Assoc Prof Julien Lescar


Lescar Julien
Born June 17th, 1966 in Paris
French citizenship
Married, 2 children


1990-1993 Ph.D. (December 1993) Université Paris XI, Orsay
Thesis work performed at the Institut Pasteur, Paris

1989 Master Degree in Physics
1988 B. Sc. Degree in Physics


Since January 2002 School of Biological Science
Nanyang Technological University, Singapore
Assistant Professor (2002)
Associate Professor (2004)

Octobre 1999 Hired as a permanent Scientist (Chargé de Recherches) with C.N.R.S, Université Joseph Fourier, Grenoble

1997-1999 Post-Doctoral Research Fellow
ESRF-EMBL Joint Structural Biology Group, Grenoble.

1995-1996 Post-Doctoral Research Fellow, Institut Pasteur, Paris

1994 Post-Doctoral Research Fellow, Washington University School of Medicine, St Louis, USA.

1990-1993 DEA, Thèse
Département d’Immunologie. Institut Pasteur, Paris
Research Interests
Structural Biology
Infectious Diseases
Structure-Based Drug Design
Current Projects
  • A*STAR-led Zika Virus Consortium
  • Bioinspired Coacervation for Green Processing of Biomolecular Composites
  • CY1400 CN Yang Programme Undergraduate Research Experience
  • Comparative studies of the structure and adhesion properties of the aLB2, aMb2, aXb2 integrin, and the crystallographic studies of the b2 and b3 integrin
  • Controlling biofilm dispersal by defined molecular switches
  • Coronavirus ribonucleocapsid assembly and its replicase enzymes : structure and function
  • Dengue NS4B Structure Study
  • Discovering inhibitors against the Dengue virus NS3 helicase and NS5 polymerase using a fragment-based approach aided by X-ray crystallography, N.M.R. and Surface Plasmon resonance
  • Dissecting the flavivirus replication complex for the discovery of antiviral inhibitors
  • Investigating the Role of HtrA Protease in Antimicrobial-Resistant Gram-Positive Infections
  • Molecular mechanisms of Plasmodium vivax malaria parasite invasion in reticulocytes
  • Role of the Universally Conserved GTPase HflX in Mycobacterial Replication
  • Self-Assembly Mechanisms of 3D Protein-Based, Robust Marine Biopolymer
  • Structural, functional and immunological characterisation of a Plasmodium multigene family associated with the pathogenesis of cerebral malaria
  • Structure study of dengue NS4B and other non-structural proteins
  • Studying Zika Virus Pathogenesis and the Development of Therapeutics, In Vitro Cell Culture Model and Mouse Model that Display Various Diseases Phenotypes
  • Targeting The Ribonucleome For Antibiotic Development
  • Targeting Vitamin B1 metabolism for antibiotic drug development
  • The SiaABCD Signaling Pathway As A Target For NovelAnti-infective Drugs Against Pseudomonas Aeruginosa(SGP-PROG3-023)
  • The Spike protein as a crucial tool to design of vaccines, ELISA- based diagnostics and therapeutics
  • The protein chemistry of integrin adhesion molecules
  • The use of a thermostable DNA/RNA dependent RNA polymerase for the large-scale synthesis of dsRNA and siRNAs pools for gene silencing
  • Towards the design of dengue virus antiviral inhibitors
  • Towards the design of specific anti-inflammatory drugs : Determination of the three dimensional structure of the TAK1 protein kinase using X-ray crystallography
  • Towards the rational design of antiviral inhibitors - x-ray crystallographic structural studies of proteins and enzymes from two RNA viruses that are important human pathogens
  • Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
  • X-ray crystallographic studies to explore the detailed DNA/RNA unwinding mechanisms of the viral helicases from SARS and hepatitis C
  • X-ray crystallography of 8 peptide-Human Leukocyte Antigen (HLA) molecules
Selected Publications
  • David Ruiz-Carrillo, Lin Jianqing, Abbas El Sahili, Meng Wei, Siu Kwan Sze, Peter F Cheung, Christian Doerig, and Julien Lescar. (2018). The protein kinase CK2 catalytic domain from Plasmodium falciparum: crystal structure, tyrosine kinase activity and inhibition. Scientific Reports, .
  • Tay, M. Y. F., Saw, W. G., Zhao, Y., Chan, W. K. K., Singh, D, Chong, Y., Forwood, J. K., Ooi, E. E., Grüber, G., Lescar, J., Luo, D., and Vasudevan, S. G. (2015). The C-terminal 50 amino acid residues of Dengue NS3 protein are important for NS3-NS5 interaction and viral replication. Journal of Biological Chemistry, 290, 2379-2394.
  • Alag R, Balakrishna AM, Rajan S, Qureshi IA, Shin J, Lescar J, Grüber G, Yoon HS. (2013). Structural Insights into Substrate Binding by PvFKBP35, a Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite Plasmodium vivax. Eukaryotic Cell, 12(4), 627-634.
  • Masayo Kotaka#, Rong Kong#, Insaf Qureshi, Qin Shi Ho, Huihua Sun, Chong Wai Liew, Lan Pei Goh, Peter Cheung, Yuguang Mu, Julien Lescar, and Zhao-Xun Liang. (2009). Structure and Catalytic Mechanism of the Thioesterase CalE7 in Enediyne Biosynthesis. Journal of Biological Chemistry, .
  • Rajamanonmani R, Nkenfou C, Clancy P, Yau YH, Shochat SG, Sukupolvi-Petty S, Schul W, Diamond MS, Vasudevan SG, Lescar J. (2009). On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. Journal of General Virology, 90, 799-809.

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