HO SUP YOON
School of Biological Science
Nanyang Technological University
60 Nanyang Drive
Singapore 637551
Singapore
Tel: +65 6316-2846
Fax: + 65 6791-3856
E-mail: hsyoon@ntu.edu.sg
EDUCATION BACKGORUND
1982 Seoul National University, Korea
BS in Food Science & Technology
1984 Korea Advanced Institute of Science and Technology, Korea
MS in Biological Science and Engineering
1993 University of Chicago, Chicago, USA
PhD in Biochemistry
PROFESSIONAL EXPERIENCE
1984-1986: Researcher, Cancer Research Institute, Seoul National University, Korea
1987-1993: Research Assistant, University of Chicago, Chicago, USA
1993-1994: Postdoctoral Fellow, Pharmaceutical Discovery Division, Abbott Laboratories, Chicago, USA
1995-1996: Research Biochemist, Pharmaceutical Discovery Division, Abbott Laboratories, Chicago, USA
1997-2000: Senior Research Scientist, Pharmaceutical Discovery Division, Abbott Laboratories, USA
2001-2002: Senior Research Scientist, Cancer Research Division, Global Pharmaceutical Research & Development, Abbott Laboratories, Illinois, USA
2008-present Adjunct Professor, Kyungpook National University, Daegu, Korea
2002-present: Associate Professor, School of Biological Sciences, Nanyang Technological University, Singapore
PROFESSIONAL SOCIETY
2002-present American Chemical Society
2002-present Protein Society |
RESEARCH INTERESTS:
Apoptotic cell death mechanism; Molecular chaperones in cancer and neurodegenerative diseases; NMR; Kinases and phosphatases involved in cell signalling pathways; Structure-based drug design
Selected Publications
1. Yoon, H.S., Hajduk, P.T., Petros, A.M., Olejniczak, E.T., Meadows, R.P., and Fesik, S.W. (1994) Solution structure of a Pleckstrin homology (PH) domain. Nature 369, 672-675.
2. Muchmore, S.W., Sattler, M., Liang, H., Meadows, R.P., Harlan, J.E., Yoon, H.S., Nettesheim, D., Chang, B.S., Thompson, C.B., Wong, S.-L., Ng, S.-C., and Fesik, S.W. (1996) X-ray and NMR structure of Bcl-XL, an inhibitor of programmed cell death. Nature 381, 335-341.
3. Sattler, M., Liang, H., Nettesheim, D., Meadows, R.P., Harlan, J.E., Eberstadt, M., Yoon, H.S., Shuker, S.B., Chang, B., Minn, A.J., Thompson, C.B., and Fesik, S.W. (1997) Structure of Bcl-XL-Bak peptide complex: Recognition between regulators of apoptosis. Science 275, 983-986.
4. Petros, A.M, Medek, A., Nettesheim, D. G., Kim, D.H., Yoon, H.S., Swift, K., Matayoshi, E.D.,Oltersdorf, T., and Fesik, S.W. (2001) Solution Structure of The Anti-Apoptotic Protein Bcl-2. Proc. Natl. Acad. Sci. USA 98, 3012-3017.
5. Kang, CB., Tai, J, Chia, J, and Yoon, HS (2005) Flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38) FEBS Letters 579, 1469-1476.
6. Kang, C.B., Ye, H, Vivekanandan, S, Simon, B., Sattler, M, and Yoon, HS (2006) Backbone 1H, 13C, and 15N resonance assignments of the N-terminal domain of FKBP38 (FKBP38NTD). J. Biomol. NMR. 36, 37.
7. Kang, T.H., Park, DY., Choi, YH., Kim, KJ., Yoon, HS, and Kim, KT (2007) Mitotic histone phosphorylation by VRK1 in mammalian cells. Mol. Cell. Biol. 27, 8533-8546.
8. Liang, Y, Ye, H., Kang, CB, Yoon, HS. (2007) Domain 2 of Non-Structural Protein 5A (NS5A) of hepatitis C virus is natively unfolded. Biochemistry 46, 11550-11558.
9. Kang, CB, Ye, H, Yoon, HR., and Yoon, HS. (2008) Solution structure of FK506-binding domain (FKBD) of Plasmodium falciparum FK506-Binding Protein 35 (PfFKBP35). PROTEINS: Structure, Function, and Bioinformatics 70, 300-302.
10. Kotaka, M, Ye, H, Alag, R, Hu, G, Bozdech, Z, Preiser, P, Yoon, HS*, Lescar, J* (2008) Crystal Structure of the FK506-binding domain of the Plasmodium falciparum FKBP35 protein in complex with FK506. Biochemistry 47, 5951-5961.
11. Kang, CB, Ye, H., Chia, Dhe-Paganon, S, and Yoon, HS (2008) FKBP Family Proteins: Immunophilins with Versatile Biological Functions. Neurosignals 16:318?325
Patents
Mutant Bcl-2 Proteins and Uses Thereof. US Patent No 01987213.4-2405-US0145693
Scientific Awards
Abbott Laboratories Drug Discovery Impact Award, 2000 |
- Characterization and search for novel extracellular porteases in Bacillus subtilis for industrial use
- In vitro and in vivo studies of Suprafenacine, a novel microtubule destabilizing anti-cancer drug
- Regulation of vaccinia-related kinase 1 (VRK1) by mH2A1.1, a histone H2A variant
- Toward development of a new class of anti-malaria drug : molecular characterization and three-dimensional structure determination of plasmodium falciparum FK506-binding protein 35 (PfFKPB35)
- Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
| Selected Publications | - Alag R, Balakrishna AM, Rajan S, Qureshi IA, Shin J, Lescar J, Grüber G, Yoon HS. (2013). Structural Insights into Substrate Binding by PvFKBP35, a Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite Plasmodium vivax. Eukaryotic Cell, 12(4), 627-634.
- Rajan S, Saw KQ, Nguyen QT, Baek K, Yoon HS. (2012). High-resolution crystal structure of FKBP12 from Aedes aegypti. Protein science, 27, 1080-1084.
- X. Hanoulle, I. Huvent, A. Leroy, H. Ye, C. B. Kang, Y. Liang, C. Rosnoblet, J. Wieruszeski. H. S. Yoon, and G. Lippens. (2011). Chapter 15: The NS5A Domain II of HCV: Conservation of Intrisic Disorder in Several GenotypesFlexible Viruses: Structural Disorder in Viral Proteins. (pp. 409-424)..
- Yang Y, Liu AQ, Lei L, Chin LK, Ohl CD, Wang QJ, Yoon HS. (2011). A tunable 3D optofluidic waveguide dye laser via two centrifugal Dean flow streams. Lab on a Chip, 11(18), 3182-3187.
- Seenuvasan Vedachalam, Bo-Hwa Choi, Kalyan Kumar Pasunooti, Kun Mei Ching, Kijoon Lee, Ho Sup Yoon, Xue-Wei Liu. (2011). Glycosylated Porphyrin Derivatives and Their Photodynamic Activity in Cancer Cells. Medicinal Chemistry Communications, 2(5), 371-377.
|
|