|Academic Profile |
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Asst Prof Shao Fangwei
Division of Chemistry & Biological Chemistry
School of Physical & Mathematical Sciences
College of Science
- PhD (Chem) California Institute of Technology 2007
- MS (PhyChem) Fudan University 2002
- BS (Chem) Fudan University 1999
|Dr. Fangwei Shao obtained Ph.D. in Bioinorganic Chemistry from California Institute of Technology in 2007. Her Ph.D. work was focused on DNA-mediated charge transport under the instructions of Professor Jacqueline Barton. Dr. Shao has explored the electric properties and redox events in double stranded DNA and the oncogenic consequences by using inorganic, organic and biochemistry methods.
She did her postdoctoral research at Dr. Scott Hilderbrand’s lab in Center for Molecular Imaging Research/Center for Systems Biology at the Massachusetts General Hospital and Harvard Medical School from August 2007 to July 2010. She has developed near infrared fluorescent agents for the detection of reactive oxygen and nitrogen species for the early diagnosis in many pathogenic processes.
She joined Division of Chemistry and Biological Chemistry at School of Methamatical and Physical Sciences in August 2010. Her current research interests lie in the redox chemistry of non-B form nucleic acids and the ramifications in biological, medicinal chemistry and medical imaging.
|Our research lies in redox chemistry in nucleic acids, especially in those adopting the non-canonical secondary structures. We will explore
the contributions of oxidative damage to the folding structures, biological functions, and the medicinal applications of non-B form nucleic acids at the interface of chemistry, biology, nanotechnology and imaging.
- Academic Research Fund Tier 1 (2016-) [by Ministry of Education (MOE)]
- Advanced Oligo Nucleotide Probes for Simultaneous RNA-DNA FISH
- Develop Platinum Complexes as Synergetic Drugs via Targeting Guanine Quadruplex
- Develop facial bioconjugate methods for specific detection of 5-hydroxymethyl-cytosine in brain tumors
- Exam the Functions of Reactive Oxygen Species in 5-Hydroxymethylcytosine Oxidation Induced DNA Demethylation
- Redox Chemistry of Non-B Form Nucleic Acids
- Tetrahedral Origami as a DNA Barcode Platform for Multiplex Protein Analysis
- Wang J, Lu k, Xuan X, Toh Z, Zhang D and Shao F. (2013). A Q1 Pt( II )–Dip complex stabilizes parallel c-myc Q2 G-quadruplex. Chemical Communications, 49, 4758.
- S A Hilderbrand, F Shao, C Salthouse, U Mahmood, R Weissleder. (2009). Upconverting luminescent nanomaterials: application to in vivo bioimaging. Chemical Communications, 28, 4188.
- F Shao, R Weissleder, S A Hilderbrand. (2008). Monofunctional carbocyanine dyes for bio- and bioorthogonal conjugation. Bioconjugate Chemistry, 19(12), 2478.
- F Shao, J K Barton. (2007). Long range electron and hole transport through DNA with tethered cyclometalated iridium(III) complexes. Journal of the American Chemical Society, 127(47), 14733.
- F Shao, K Augustyn, J K Barton. (2005). Sequence dependence of charge transport through DNA domains. Journal of the American Chemical Society, 127(49), 17445.
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