Nanyang Technology University

Academic Profile
Asst Prof Shao Fangwei 
Nanyang Assistant Professor (NTU)
 
Division of Chemistry & Biological Chemistry 
School of Physical & Mathematical Sciences 
College of Science 



Email: FWSHAO@ntu.edu.sg
Phone: (+65)65922511 
Office: SPMS-CBC-04-22 
Education
  • PhD (Chem) California Institute of Technology 2007
  • MS (PhyChem) Fudan University 2002
  • BS (Chem) Fudan University 1999
Biography
Dr. Fangwei Shao obtained Ph.D. in Bioinorganic Chemistry from California Institute of Technology in 2007. Her Ph.D. work was focused on DNA-mediated charge transport under the instructions of Professor Jacqueline Barton. Dr. Shao has explored the electric properties and redox events in double stranded DNA and the oncogenic consequences by using inorganic, organic and biochemistry methods.

She did her postdoctoral research at Dr. Scott Hilderbrand’s lab in Center for Molecular Imaging Research/Center for Systems Biology at the Massachusetts General Hospital and Harvard Medical School from August 2007 to July 2010. She has developed near infrared fluorescent agents for the detection of reactive oxygen and nitrogen species for the early diagnosis in many pathogenic processes.

She joined Division of Chemistry and Biological Chemistry at School of Methamatical and Physical Sciences in August 2010. Her current research interests lie in the redox chemistry of non-B form nucleic acids and the ramifications in biological, medicinal chemistry and medical imaging.
Research Interests
Our research lies in redox chemistry in nucleic acids, especially in those adopting the non-canonical secondary structures. We will explore
the contributions of oxidative damage to the folding structures, biological functions, and the medicinal applications of non-B form nucleic acids at the interface of chemistry, biology, nanotechnology and imaging.
Research Grant
  • Start Up Grant (2010-)
Current Projects
  • Redox Chemistry of Non-B Form Nucleic Acids
Selected Publications
  • Wang J, Lu k, Xuan X, Toh Z, Zhang D and Shao F. (2013). A Q1 Pt( II )–Dip complex stabilizes parallel c-myc Q2 G-quadruplex. Chemical Communications, 49, 4758.
  • Jintao Wang, Kaihui Lu, Shuguang Xuan, Zaozhen Toh, Dawei Zhang, Fangwei Shao. (2013). A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex. Chemical Communications, 49(42), 4758-4760.
  • S A Hilderbrand, F Shao, C Salthouse, U Mahmood, R Weissleder. (2009). Upconverting luminescent nanomaterials: application to in vivo bioimaging. Chemical Communications, 28, 4188.
  • F Shao, R Weissleder, S A Hilderbrand. (2008). Monofunctional carbocyanine dyes for bio- and bioorthogonal conjugation. Bioconjugate Chemistry, 19(12), 2478.
  • F Shao, J K Barton. (2007). Long range electron and hole transport through DNA with tethered cyclometalated iridium(III) complexes. J. Am. Chem Soc, 127(47), 14733.
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