|Liu Ding Xiang
PhD University of Cambridge 1991
MSc Sichuan University (formerly West China University of Medical Sciences) 1986
Principal Investigator, Institute of Molecular and Cell Biology, Singapore
Principal Investigator, Institute of Molecular Agrobiology, Singapore.
Research Associate, Department of pathology, University of Cambridge, UK.
Research Associate, Department of Medicine, University of Cambridge, UK.
Lecturer, Sichuan University, China.
Medical Microbiologist, Huangshi Central Hospital, Hubei, China.
My current research focuses on the molecular cell biology, virus-host interactions, replication mechanisms and pathogenesis of coronavirus and dengue virus. Systematic characterization of the molecular and cellular events occurring during the life cycles of coronavirus and dengue virus, including host responses to the infection and the functions of individual viral proteins in their replication and pathogenesis, would greatly increase our understanding of the biology of these viruses. Such an understanding will ultimately lead to the development of anti-viral prophylactic and therapeutic approaches, such as vaccines and drugs.
Current projects include:
1. Global screen and characterization of host cell factors involved in the replication and pathogenesis of coronavirus and dengue virus.
2. Characterization of host anti-viral responses, especially the pathways involved the Toll-like receptors and RIG-I-like receptors, during coronavirus and dengue infections.
3. Functional analysis of viral RNA elements and proteins in the replication and pathogenesis of coronavirus and dengue virus, by using reverse genetics approaches.
4. Exploration of the potential of using coronavirus as delivery and therapeutic vectors.
- Development of Virus-Controlling Biotechnologies for Cost Efficient & Sustainable Aquaculture
- Functional and Structural Studies of Coronavirus Ribonucleocapsid Assembly and Its Interactions With Host Cells
- Molecular Studies of the Replication Mechanisms, Virus-Host Interactions and Pathogenesis of Coronavirus and Dengue Virus
- K. Pervushin, E. Tan, K. Parthasarathy, X. Lin, F.L. Jiang, D. Yu, A. Vararatannavech, T.W. Soong, D.X. Liu and J. Torres. (2009). Structure and inhibition of the SARS Coronavirus Envelope Protein Ion Channel. PLoS Pathogens, .
- Krupakar Parthasarathy, Lifang Ng, Xin Lin, Ding Xiang Liu, Konstantin Pervushin, Xiandi Gong and Jaume Torres. (2008). Structural flexibility of the pentameric SARS coronavirus envelope protein ion channel. Biophysical Journal, 95, L39-L41.
- Torres, J., Maheswari, U., Parthasarathy, K., Ng, L., Ding, X.L., Gong, X. (2007). Conductance and amantadine binding of a pore formed by a lysine-flanked transmembrane domain of SARS coronavirus envelope protein. Protein science, 16(9), 2065-2071.
- Liao Y., Tam, J.P., and Liu, D.X. (2006). Viroporin activity of SARS-CoV E protein. Advances in Experimental Medicine and Biology, 581, 199-202.
- Tan YW, Fang S, Fan H, Lescar J, Liu DX. (2006). Amino-acid residues critical for RNA binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells. Nucleic Acids Research, 34, 4816-4825.