|Our laboratory is interested in the signal transduction events involving small GTPases of the Rho family, their regulators and effectors. These proteins play key roles in transducing extracellular stimuli into distinct responses including cell shape changes, cell motility, adhesion, cell division and phagocytosis. The emphasis of our current research is on the kinase PAK, its interacting protein PIX and a family of serine/threonine phosphataes of the PP2C family, POPXs.|
- Regulation of the Kinesin-2 Motor Complex by POPX2 phosphastase
- The Regulation of Actin Cytoskeleton In Mouse Embryonic Stem Cells During Self Renewal and Differentiation
- The Regulations of Actin Cytoskelenton in Embryonic Stem Cells
- The challenge of real-time imaging of signaling pathways in embryonic stem cells : is mES cell pluripotency related to cadherin signaling and their epithelial-like behaviour?
- The regulation of actin cytoskeleton and cellular functins by POPX2 and its partners
- The regulation of cell motility, phagocytosis and macropinocytosis downstream of the Rho GTPase signalling pathways
- The regulatory pathways integrating the cortical actin network and spindle dynamics during early stages of mitosis
- Singh P, Gan CS, Guo T, Sze SK and Koh CG. (2011). Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis. Proteomics, 11(14), 2891-2900.
- Heng YW and Koh CG. (2010). Action Cytoskeleton Dynamics and the Cell Division Cycle. International Journal of Biochemistry and Cell Biology, 42, 1622-1633.
- Susila, A, Chan H, Loh AXW, HQ Phang, ET Wong, Tergaonkar V and Koh CG. (2010). POPX2 phosphatase regulates cancer cell motility and invasiveness. Cell Cycle, 9, 179-187.
- Wong CH, Chan H, Ho CY, Lai SK, Chan KS, Koh CG* & Hoi-Yeung Li*. (2009). Apoptotic histone modification inhibits nuclear transport by regulating RCC1. Nature Cell Biology, 11, 36-45.
- Xie Y, Tan EJ, Wee S, Manser E, Lim L, Koh CG. (2008). Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways. Journal of Cell Science, 121, 514-521.