Academic Profile

Academic Profile

Assoc Prof Ali Gilles Tchenguise Miserez

Associate Professor

School of Materials Science & Engineering
College of Engineering

Phone: (+65)63168979/65927947
Office: N4.1-01-16/RTP-XF-06-05C

  • PhD (Matrls Sc & Eng) Ecole Polytechnique Federale de Lausanne 2003
  • MBA (Mgt of Tech) Ecole Polytechnique Federale de Lausanne 2002
  • MA (Matrls Sc & Eng) Ecole Polytechnique Federale de Lausanne 1998
Ali Miserez is a Faculty member in the School of Materials Science and Engineering and the School of Biological Sciences at Nanyang Technological University (NTU) in Singapore. He graduated from the Ecole Polytechnique Fédérale de Lausanne (EPFL, Switzerland) with a PhD in Materials Science and Engineering (2003) and a specialization in advanced metal/ceramic composites and mechanics of materials. In 2004, he received a Swiss National Science Foundation post-doc fellowship and moved to the University of California, Santa Barbara (UCSB), where he was affiliated with the Materials Department and the Marine Science Institute. At UCSB, he expanded his research interest towards biological materials and biomimetics working in the group of Prof. Herb Waite. In 2009, he moved to NTU as an Assistant Professor, and in 2011 he was awarded the Singapore National Research Foundation (NRF) Fellowship, a $3 Million individual research grant for early career scientists.

Dr. Miserez’s research is centered on revealing the molecular, physico-chemical, and structural principles from unique biological materials, and on translating these designs into novel biomimetic synthesis strategies. His research group is strongly cross-disciplinary, with molecular biologists, chemists, bio-physicists, and materials scientists combining their expertise towards bioinspired engineering from various angles, including protein biochemistry, extra-cellular tissue transcriptomic, polymer chemistry, biomimetic peptide design, biophysics, and nanomechanics. In recent years, his work has appeared in both general (Science, Nature Materials, Nature Biotechnology, Nature Chemical Biology, Advanced Materials) and specialized journals (Biomacromolecules, ACS Nano, JBC, Polymer Chemistry, etc, ). He has delivered numerous invited talks, including at various Gordon Research Conferences in the field of bioinspired materials and biomineralization.
Research Interests
Structural properties of biological materials from the macro-scale to the nano-scale
Multi-scale structural and mechanical properties of biological materials, including biominerals.
Elastomeric and structural properties of bioelastomers
Protein chemistry of sclerotized hard-tissues from marine organisms, such as Cephalopod
Single-molecular force spectroscopy of structural and elastic proteins
Underwater adhesion mechanisms of adhesive proteins
RNA-sequencing and proteomics of extra-cellular biological materials
Advanced Metal/Ceramic composites
Experimental Fracture Mechanics
Research Grant
  • Academic Research Fund Tier 1 (2016-)
  • Academic Research Fund Tier 2 (2016-)
  • NRF Competitive Research Program (2015-) [by National Research Foundation (NRF)]
  • NRF-ANR Joint Call 2015 (2016-)
  • Office of Naval Research Global, USA (2017-) [by Office of Naval Research Global, USA]
  • Singapore Maritime Institute (2013-2017) [by Singapore Maritime Institute (SMI)]
Current Projects
  • Bio-Inspired Materials: Lessons from Biopolymeric Tissues of Marine Organisms
  • Bioinspired Coacervation for Green Processing of Biomolecular Composites
  • Biomimetic production of customizable bacterial cellulose through synthetic biology approach
  • Biomimetic-Based Antifouling Coatings as a Route to Imporve Energy Efficiency of Ships and Port Structures
  • Development of adhesive mimics for anti-fouling coatings and adhesion testing in the marine environment
  • Frontiers in Physical and Life Sciences: Bio-inspired and Biomimetic Materials (NRF-NRFRF2011-06)
  • Modulation of Mesenchymal Stems Cells Differentiation using Biomimetic materials
  • Molecular mechanisms of Barnacle Adhesion: A Combined Structural Biology and Computational Study
  • Next-Gen Sequencing and Proteomics of Natural Biopolymers
  • PREcipitation of Artificial Structural PROteins and POlySAccharides into nanocapsuLEs (PREPROPOSAL)
  • Potential Marine Antifouling Agents : Synthesis and Formulation of Novel Halogeneatd Cyclopent - 2 - ones
  • Potential Marine Antifouling Agents: Synthesis and Formulation of Novel Halogenated Cyclopent-2-ones
  • Self-Assembly Mechanisms of 3D Protein-Based, Robust Marine Biopolymer
Selected Publications
  • L. Petrone, A. Kumar, C. N. Sutanto, N. J. Patil, S. Kannan, A. Palaniappan, S. Amini, B. Zappone, C. Verma, and A. Miserez. (2015). Wet Adhesion of Mussels is Dictated by Molecular Conformation and Time-Regulated Secretion of Mussel Adhesive Proteins. Nature Communications, 6, 8737.
  • S. Amini, M. Tadayon, S. Idalapati, and A. Miserez*. (2015). The Role of Quasi-Plasticity in the Ultra Contact Damage Tolerance of the Stomatopod Dactyl Club. Nature Materials, 14, 943-950.
  • YP. Tan, S. Hoon, P. Guerette, W. Wei, A. Ghadban, C. Hao, A. Miserez. (2015). Infiltration of Chitin by Protein Coacervates Defines the Squid Beak Mechanical Gradient. Nature Chemical Biology, 11(9), 488–495.
  • Guerette, P.A., Hoon, S., Seow, Y., Raida, M, Masic, A., Wong, F.T., Ho, V.H.B, Whye, K.K., Demirel, M.C., Pena-Francesch, A., Amini, S., Tay G., Ding D., & Miserez, A. (2013). Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science. Nature Biotechnology, 31(10), 908-915.
  • J.C. Weaver#, S. Milliron#, A. Miserez#, K. Evans-Lutterodt, S. Herrera, I. Gallana, WJ. Mershon, B. Swanson, PD. Zavattieri, E. DiMasi, and D. Kisailus*. (2012). The Stomatopod Dactyl Club: A Formidable Damage-Tolerant Biological Hammer. Science, 336, 1275-1280.

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