Academic Profile

Academic Profile

Assoc Prof Naohiko Yoshikai

Associate Professor, School of Physical & Mathematical Sciences - Division of Chemistry & Biological Chemistry

Assoc Prof Naohiko Yoshikai

Naohiko Yoshikai was born in Tokyo, Japan in 1978. He received B.S. (2000), M.S. (2002), and Ph.D. (2005) degrees from Department of Chemistry, The University of Tokyo under the guidance of Prof. Eiichi Nakamura. During that time, he was a Young Research Fellow of JSPS (2002-2005) and a visiting student at Stockholm University (w/ Prof. Jan-E. Bäckvall, 2002). After completion of his PhD study, he served as an Assistant Professor at the University of Tokyo since 2005 until 2009 June. In 2009 July, he moved to Nanyang Technological University, Singapore, and has started his research group as Nanyang Assistant Professor and National Research Foundation Research Fellow. He has been awarded Takasago International Corporation Award from Society of Synthetic Organic Chemistry of Japan (2008), Chemistry Innovation UT Global COE Lectureship (2008), and Inoue Research Award for Young Scientists (2007) for his excellence in organometallic catalysis.
Research Interests
Our major research interests focus on mechanism, design, and development of novel homogeneous catalysis that allows efficient and environmentally benign synthetic transformations of simple, unactivated molecules into useful building blocks for electronically and biologically active compounds. The following keywords characterize our research programs: Exploration of novel catalytic activities of ubiquitous and non-toxic metals, activation and functionalization of otherwise unreactive chemical bonds and small molecules, rational design of innovative catalysis through the interplay of theory and experiments.
Current Projects
  • Base Metal Multicatalysis for C-H Activations and Multicomponent Couplings
  • Catalyst Design of Cobalt Complexes for the Development of New Organic Reactions
  • Catalytic Asymmetric Addition and Substitution Reactions via Metal Homoenolates
  • Development of Cooperative Transition Metal Catalysis for Carbon-Carbon Bond Formation
  • Development of Enantioselective C-H Bond Functionalizations With Cobalt Catalysts
  • Development of Versatile Synthetic Approaches to Heteroles and Their Benzo-Fused Analogues
  • Divergent Synthesis of Enol Ethers and Enolates from NonCarbonyl Feedstock
  • Expanding the Chemical Space of Heterocycles by Novel C–C and C–Heteroatom Coupling Methods
  • Mechanistic Study of Low-Valent Cobalt Catalysts for C-H Bond Activation
  • Novel Catalytic Multicomponent Synthesis of Densely Functionalized Heteroarenes and Olefins
  • Seed Funding
Selected Publications
  • Gao, K.; Yoshikai, N. (2011). Regioselectivity-Switchable Hydroarylation of Styrenes. Journal of the American Chemical Society, 133(3), 400-402.
  • Gao, K.; Lee, P.-S.; Fujita, T.; Yoshikai, N. (2010). Cobalt-Catalyzed Hydroarylation of Alkynes through Chelation-Assisted C-H Bond Activation. Journal of the American Chemical Society, 132(35), 12249-12251.
  • Ding, Z.; Yoshikai, N. (2010). Cobalt-Catalyzed Addition of Azoles to Alkynes. Organic Letters, 12(18), 4180-4183.
  • Yoshikai, N.; Matsuda, H.; Nakamura, E. (2009). Hydroxyphosphine Ligand for Nickel-Catalyzed Cross-Coupling through Nickel/Magnesium Bimetallic Cooperation. Journal of the American Chemical Society, 131(27), 9590-9599.
  • Yoshikai, N.; Matsumoto, A.; Norinder, J.; Nakamura, E. (2009). Iron-Catalyzed Chemoselective ortho Arylation of Aryl Imines by Directed C-H Bond Activation. Angewandte Chemie International Edition, 48(16), 2925-2928.

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