Academic Profile

Academic Profile

Assoc Prof Liu Xuewei

Professor, School of Physical & Mathematical Sciences

Email: xuewei@ntu.edu.sg
Assoc Prof Liu Xuewei

Biography
Associate Professor LIU Xuewei
Division of Chemistry and Biological Chemistry
School of Physical & Mathematical Sciences
College of Science
Nanyang Technological University
E-mail: xuewei@ntu.edu.sg

Professional Experiences
2012-now Associate Professor in Chemistry, NTU, Singapore
2006-2012 Assistant Professor in Chemistry, NTU, Singapore
2003-2005 Postdoctoral Research Fellow, California Institute of Technology
2002-2003 Senior Research Scientist, Chugai Pharma USA
2000-2002 Research Scientist, Proctor & Gamble Pharmaceuticals

Education
2003-2005 Postdoctoral Research Fellow, California Institute of Technology
2000 PhD in Chemistry, University of Southern California
1996 BSc and MSc in Chemistry, China Agricultural University, President Award

Awards and Honors
2012 The 7th Asian Core Program (ACP) Lectureship Award (to China)
2012 CoS Collaborative Research Award
2011 The 6th Asian Core Program (ACP) Lectureship Award (to Taiwan)
2011 The 6th Asian Core Program (ACP) Lectureship Award (to Korea)
2009 Young Researcher Award
2007 Excellent Presentation Award, Thailand
2006 The 1st Asian Core Program (ACP) Lectureship Award (to Japan)
1999 Liang Fellowship, University of Southern California
1998 President Research Fellowship, Nagoya University, Japan
Research Interests
Research Interests

The research program in our group integrates organic chemistry, chemical biology, medicinal chemistry and materials chemistry. A special emphasis is placed on training and research in carbohydrate synthesis and on the utilization of this expertise in addressing problems of medicinal and biochemical significance.

i. Carbohydrate chemistry
ii. Glycopeptide and glycoprotein synthesis
iii. Glycobiology
iv. Antimicrobial Research
v. Glycal-oriented synthesis of natural products
vi. Functional materials


Selected Publications (1 paper is selected from each year of 2011-2016)

Hua Chai‡, Kim Le Mai Hoang‡, Minh Duy Vu, Kalyan Pasunooti, Chuan-Fa Liu and Xue-Wei Liu#, “N-Linked Glycosyl Auxiliary-Mediated Native Chemical Ligation on Aspartic Acid: Application towards N-Glycopeptide Synthesis”, Angew. Chem. Int. Ed., 2016, 55, 10363-10367. Highlighted by X-MOL.

Shaohua Xiang, Kim Le Mai Hoang, Jingxi He, Yujia Tan and Xue-Wei Liu#, “Reversing the Stereoselectivity of a Palladium-Catalyzed O-Glycosylation through an Inner-Sphere or Outer-Sphere Pathway”, Angew. Chem. Int. Ed., 2015, 54, 604-607.

Kim Le Mai Hoang and Xue-Wei Liu#, “The Intriguing Dual-Directing Effect of 2-Cyanobenzyl Ether for Highly Stereospecific Glycosylation Reaction”, Nat. Commun., 2014, 5, 5051.

Jing Zeng, Jimei Ma, Shaohua Xiang, Shuting Cai, and Xue-Wei Liu#, “Stereoselective β-C-Glycosylation via Palladium-Catalyzed Decarboxylative Allylation: Formal Synthesis of Aspergillide A”, Angew. Chem. Int. Ed., 2013, 52, 5134-5137. Highlight in Synfacts 2013, 9, 870.

Bala Kishan Gorityala‡, Zhiqiang Lu‡, Min Li Leow, Jimei Ma, and Xue-Wei Liu#, “Design of a “Turn-off/Turn-on” Biosensor: Understanding Carbohydrate-lectin Interactions to Utilization in Noncovalent Drug Delivery”, J. Am. Chem. Soc., 2012, 134, 15229-15232.

Rujee Lorpitthaya, Sharad B. Suryawanshi, Siming Wang, Kalyan Kumar Pasunooti, Shuting Cai, Jimei Ma, and Xue-Wei Liu#, “Total Synthesis of Sialic Acids by a Sequential Rhodium-Catalyzed Azridination and Barbier Allylation of D-Glycal”, Angew. Chem. Int. Ed., 2011, 50, 12054-12057
Current Projects
  • Antimicrobial polymeric nanoparticles with good efficacy in a complex environment
  • Application of Molecular Dynamics Simulation in Determining Protein Stability Prior to Protein Expression
  • Biomass and Waste Conversion to Biofuels and High Value Materials
  • De Novo Approaches for Glycobiology-driven Oligosaccharide Synthesis
  • Discovery of Sialic Acid-Based Influenza Antiviral Agents (DiscSIA)
  • Glycocode-Oriented Drug Delivery into Breast Cancer Cells
  • HL9 Based D-Peptide Design as HIV Entry Inhibitor
  • Intramolecular Decarboxylative Glycosylation: Synthesis of Carbohydrates and Natural Products
  • New Strategies for the Stereo Control of Polyene Cyclization: Total Synthesis and Biological Evaluation of Bioactive Natural Products
  • Novel Chemical System for Gene Delivery
  • Polysaccharide (PSa) block optimization
  • Rapid Microfluidic Detection of Drug-Resistant Bacteria via Metabolic Labeling
  • Ready Access to Biologically Active Aminoglycosides with New Structural Features
  • Seeking Selective and Sensitive Ligands for Hemagglutinin of H7N9 Influenza Virus: A Potential Sugarcode-Based Diagnostic
  • Selective contact-active antimicrobial bio-macromolecules
  • Sub-Project 2
  • Total Synthesis and Biological Study of Rhizochalin A; Chemical Probes for Molecular Imaging and for Understanding Biological Pathways and as Therapeutic Agents for the Treatment of Neural Disorders; New Methodologies for the Synthesis of Aminoglycosides
  • Ultrafast-Charging and High-Power Lithium Ion Batteries with Novel Two-Dimension Electrode Materials
  • Understanding Molecular Mechanism of Supradamal, a Novel Adamantanyl-Based Antimalarial Drug
  • dNCL for Quick N-Glycoprotein Synthesis: From Method to Application
Selected Publications
  • Chan-Park MB;. (2018). Oxadiazabicyclooctenone as a versatile monomer for the construction of pH sensitive functional polymers via ROMP. Polymer Chemistry, .
  • Wei-Lin Leng, Hongze Liao, Hui Yao, Zi-En Ang, Shaohua Xiang and Xue-Wei Liu#. (2017). Palladium-Catalyzed Decarboxylative Allylation/Wittig Reaction: Substrate-Controlled Synthesis of C-Vinyl Glycosides. Organic Letters, 19, 416-419.
  • 2. Xumeng Wu, Yu Jia Tan, Hui Ting Toh, Lan Huong Nguyen, Shu Hui Kho, Sing Yian Chew, Ho Sup Yoon and Xue-Wei Liu#. (2017). Stimuli-responsive Multifunctional Glyconanoparticle Platforms for Targeted Drug Delivery and Cancer Cell Imaging. Chemical Science, .
  • 6. Ronny William, Siming Wang, Asadulla Mallick and Xue-Wei Liu#. (2017). Interrupting Nazarov Reaction with New Trapping Modality: Utilizing Potassium Alkynyltrifluoroborate as σ-Nucleophile. Organic Letters, 18, 4458.
  • Ronny William, Wei-Lin Leng, Siming Wang and Xue-Wei Liu#. (2016). The First Intermolecular Interrupted Imino-Nazarov Reaction: Expeditious Access to Carbocyclic Nucleoside Analogues. Chemical Science, 7, 1100-1103.

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