Academic Profile

Academic Profile

Assoc Prof Tan Thatt Yang Timothy

Associate Professor, School of Chemical and Biomedical Engineering
Deputy Director, CN Yang Scholars Programme

Email: tytan@ntu.edu.sg
Assoc Prof Tan Thatt Yang Timothy

Biography
PhD (Chemical Engineering), Feb 2004 – University of New South Wales, Australia.

Thesis “Photocatalytic Reduction of Selenate and Selenite: Water/Wastewater treatment and the Formation of Nano-Selenium Compounds” under the International Postgraduate Research Awards (IPRS), Australia.
Research Interests
1. Nanomedicine: Design and Engineering of Multifunctional Nanomaterials for simultaneous targeting, bio-imaging and drug delivery.

The research objective of this work is to apply nanotechnology to medicine. We have developed a new class of florescent-magnetic nanoparticles as probes and aim to demonstrate their application in both fluorescent microscopy and MRI. Subsequent work will be undertaken to introduce multifunctional organic, organometallic or biological groups into nanostructured materials to render them with biocompatibility, targeting, drug loading and delivery functions. The cytotoxicity of such nanomaterial will also be evaluated.

2. Design of Nanoparticles for Drug Separation.

The project focuses on the development of nano-sized achiral and chiral packing materials for Super-critical fluid Chromatography (SFC), Capillary Electrophoresis (CE) and Capillary Electrochromatography (CEC). Judging from the viewpoint of novelty of science, there are to date no known research work published in open literature on the application of chiral-nanomaterials having size ranging < 1.5 ?m for SFC, CE and CEC analyses. The reduction in size of packing materials is anticipated to lead to a huge increase in chromatographic resolution.

3. Advanced Materials for Green Architecture: Nanocomposites for Permanent Self-cleaning and Antibacterial Surface.

This research focuses on synthesizing scratch resistant nanocomposite coating that are photocatalytic, superhydrophilic and antibacterial. This material can then be coated to surfaces inside and outside buildings and structures for permanent self-cleaning and antibacterial functions. Current work includes exploring various synthesis methods (including atomic deposition, sonication and sol-gel) that will give the most efficient materials.
Current Projects
  • A New Treatment Strategy for Cancer Immunotherapy Using Near-infrared Responsive Hydrogels as an Injectable Therapeutic Device for In-situ Modulation of Tumour Microenvironment
  • A Preliminary Study of An Injectable Delivery System for Targeted and Trackable Collagen Crosslinker Delivery in Myopic Guinea Pigs
  • A novel wide-spectrum antimicrobial nanocomposite: a synergistic superhydrophobic and antimicrobial coating for passive and active antimicrobial activity
  • Development of Graphene Oxide Quantum Dots Functionalized Membrane with Significantly-Enhanced Bactericidal and Antimbiofouling Performance
  • Multi-Scale Systems For Simultaneous Bio-Solar Energy Harvesting And Waste Remediation
Selected Publications
  • Charlene J W Ng, Han Gao, Timothy Thatt Yang Tan. (2008). Atomic layer deposition of TiO2 nanostructures for self-cleaning applications. Nanotechnology, 19, 445604.
  • Yong Wang; Yin Xiao; Timothy Thatt Yang Tan; Siu Choon Ng. (2008). Click chemistry for facile immobilization of cyclodextrin derivatives onto silica as chiral stationary phases. Tetrahedron Letters, .
  • Timothy T. Tan, S. Tamil Selvan, Zhao Lan, Shujun Gao, Jackie Y. Ying. (2007). Size Control, Shape Evolution and Silica Coating of Near-Infrared-Emitting PbSe Quantum Dots. Chemistry of Materials, 19 (13), 3112.
  • Zhang Y.X., Guo J., White, T., Tan T.T.Y. and Xu R.*. (2007). Y2O3: Tb nanocrystals self-assembly into nanorods by oriented attachment mechanism. The Journal of Physical Chemistry Part C: Nanomaterials, Interfaces and Hard Matter, 111(22), 7893.
  • Selvan T. Selvan, Timothy Thatt Yang Tan, Jackie Y. Ying. (2005). Robust, Non-Cytotoxic, Silica-Coated CdSe Quantum Dots with Efficient Photoluminescence. Advanced Materials, .

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