Academic Profile

Academic Profile

Assoc Prof Sze Siu Kwan

Associate Professor, School of Biological Sciences

Email: sksze@ntu.edu.sg
Assoc Prof Sze Siu Kwan

Biography
SZE Siu-kwan Newman received multidisciplinary research trainings in chemical physics, protein chemistry, protein separation and characterization, and proteomics from University of Hong Kong, University of Toronto, University of Waterloo, and Cornell University under prominent research mentors (Nobel Laureate Professor John Polanyi - Chemical Physics, Professor Janus Pawlizyn - Protein Science, and Professor Fred McLafferty - Mass Spectrometry). After the intensive trainings, he engaged in the R&D of emerging proteomics technology in the Genome Institute of Singapore. After he joined NTU in June 2006, he has embarked on the establishment of a state-of-the-art proteomics facility in School of Biological Sciences and the application of advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines.

Academic Qualifications/Professional Preparation:
1987-1990 B.Sc. (Chemistry, First Class Honors), University of Hong Kong
1990-1995 Ph.D. (Chemical Physics), University of Hong Kong
1995-1998 Postdoctoral Fellow (Chemical Physics), University of Toronto, Canada
1998-2001 Postdoctoral Fellow (Analytical Chemistry), University of Waterloo, Canada
2001-2002 Visiting Scientist (Proteomics for Life Sciences), Cornell University, USA
Research Interests
Our research is devoted to develop and apply advanced proteomic technologies to decipher human diseases through a rational search for novel disease targets and medicines. As proteomics is still in the infancy stage, technology development is the key to advance the field to address more sophisticated biomedical questions. During the past few years, we have successfully developed a few novel proteomic techniques and applied to study proteins that are important to transcriptional and translational regulatory networks, DNA repair, and apoptotic pathway. More importantly, we have established a biological and biomarker discovery pipeline to study clinically important proteome systems relevant to host-pathogen response, cancer, and cardiovascular diseases
Current Projects
  • A comprehensive survey of the interactome inside the cytoplasm of red blood cell infected by Plasmodium parasite
  • Defining how brain tissue-derived exosomes promote experimental and human dementia
  • Dissecting the Roles of Scaffolding Proteins in Ras Signaling Pathways
  • Employment of bio-mimetic culture system as tumor microenvironment surrogate to elucidate tumor-stroma interaction
  • Enabling phosphorproteome analysis with mass spectrometry in elucidating signalling pathways in cancer and immunity
  • Herbalomics: Novel approach for fingerprinting and authentication of herbal products
  • Identification of human plaque protein signatures predictive for secondary cardiovascular events using quantitative proteomics
  • In vivo structure-based studies on epidermal growth factor receptor (EGFR) signaling in cancer
  • Investigating nuclear dynamics of excitatory neurons and astrocytes during epileptogenesis
  • Investigation of the nucleolus as a novel target for complement C1q binding and a source of novel substrate for C1q-associate proteases C1r/C1s
  • Preclinical development of a cancer immunotherapy targeting tumour exosomes/EVs
  • Proteomic study of hypoxia-induced PTMs: potential targets for cancer therapy
  • Proteomics investigation on the molecular mechanism of hypoxia induced cancer metastasis
  • Selective contact-active antimicrobial bio-macromolecules
  • Signaling during Plasmodium falciparum merozoite invasion
  • Signatures of human plaque protein levels predictive for human cardiovascular events/Quantitative proteomics on human plaque protein extracts
  • Study Early Asymptomatic Molecular Pathology Of Neurodegeneration In Dementia: Proteomic Identification Of Priority Drug Targets
  • The Impact of Circulating Microvesicles in Immune-Mediated Diabetes Mellitus of Humans – A Transethnic Approach
  • The Role Of Protein Deamidation In Subclinical Cardiovascular Disease
  • The Role Of Protein Deamidation In Subclinical Cardiovascular Disease
  • Understanding how cancer-preventing bioactive dietary compounds (BDCs) reduce risk of malignancy through epigenetic mechanisms by profiling chromatin-associated proteome
  • Validating candidate biomarkers in plasma microvesicles for the diagnosis and prognosis of lacunar infarction
Selected Publications
  • P. Hao, T. Guo and S. K. Sze. (2011). Simultaneous analysis of proteome, phospho- and glycoproteome of rat kidney tissue with electrostatic repulsion hydrophilic interaction chromatography. PLoS ONE, 6(2), e16884.
  • T. Guo, Y. Zhu, C. S. Gan, S. S. Lee, J. Zhu, H. Wang, X. Li, J. Christensen, S. Huang, O. L. Kon and S. K. Sze. (2010). Quantitative Proteomics Discloses MET Expression in Mitochondria as a Direct Target of MET Kinase Inhibitor in Cancer Cells. Molecular and Cellular Proteomics, 9(12), 2629-41.
  • W. Peeters, D. P. de Kleijn, A. Vink, S. van de Weg, A. H. Schoneveld, S. K. Sze, P. J. van der Spek, J. P. de Vries, F. L. Moll and G. Pasterkamp. (2010). Adipocyte fatty acid binding protein in atherosclerotic plaques is associated with local vulnerability and is predictive for the occurrence of adverse cardiovascular events. European Heart Journal, .
  • T. Guo, S. S. Lee, W. H. Ng, Y. Zhu, C. S. Gan, J. Zhu, H. Wang, S. Huang, S. K. Sze and O. L. Kon. (2010). Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome. Cellular and Molecular Life Sciences, .
  • Adav SS, Li AA, Manavalan A, Punt P, Sze SK. (2010). Quantitative iTRAQ secretome analysis of Aspergillus niger reveals novel hydrolytic enzymes. Journal of Proteome Research, 9(8), 3932-40.

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